Dr. De Serres received his MD from University of Montreal and FRCPC in Internal Medicine and Nephrology following residency at Laval University in Canada. He then completed a 3-year Research Fellowship in transplant immunology at the Brigham and Women’s Hospital and received a Master of Epidemiology from Harvard School of Public Health. He is currently Associate Professor of Medicine at Laval University and Clinician-Scientist Junior II FRQS scholar.

At the national level, he has served as Chair of the 2018 Canadian Society of Transplantation Scientific Committee, in charge of organizing the Canadian Transplant Summit. At the international level, he has been elected as Executive Member of American Society of Transplantation Transplant Diagnostic Committee for a 2-year term, from 2016 to 2018. He also served as a member of the AST Transplantation and Immunology Research Network Scientific Committee from 2015 to 2018.

His research program focuses on cell-based assays to identify over-immunosuppression and on the mechanisms of antibody-mediated rejection. Since 2011, he has received continuous funding from different agencies including Kidney Foundation of Canada, CIHR, CFI and FRQS. His lab is currently funded by a CIHR Project Scheme grant and he is co-investigator and collaborator on several multicenter projects, including the CIHR-funded TMCT-04 trial and the Genome Canada-funded Can PREVENT AMR study.

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Québec, Québec
Canada G1R 2J6
+1 418-525-4444, extension 16839
Sacha.DeSerres@crchudeque...

Latest news

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Batal I, Vasilescu ER, Dadhania DM, Adel AA, Husain SA, Avasare R, Serban G, Santoriello D, Khairallah P, Patel A, Moritz MJ, Latulippe E, Riopel J, Khallout K, Swanson SJ, Bomback AS, Mohan S, Ratner L, Radhakrishnan J, Cohen DJ, Appel GB, Stokes MB, Markowitz GS, Seshan SV, De Serres SA, Andeen N, Loupy A, Kiryluk K, D'Agati VD

Association of HLA Typing and Alloimmunity With Posttransplantation Membranous Nephropathy: A Multicenter Case Series.

Journal Article

Am J Kidney Dis, 2020, ISSN: 0272-6386.

Abstract | Links:

Bouchard-Boivin F, Desy O, Beland S, Houde I, De Serres SA

TNF-α Production by Monocytes Stimulated With Epstein-Barr Virus-Peptides as a Marker of Immunosuppression-Related Adverse Events in Kidney Transplant Recipients.

Journal Article

Kidney Int Rep, 4 (10), pp. 1446-1453, 2019, ISSN: 2468-0249.

Abstract | Links:

Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, Edwards R, Agarwal R, Bakris G, Bull S, Cannon CP, Capuano G, Chu PL, de Zeeuw D, Greene T, Levin A, Pollock C, Wheeler DC, Yavin Y, Zhang H, Zinman B, Meininger G, Brenner BM, Mahaffey KW, CREDENCE Trial Investigators

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.

Journal Article

N Engl J Med, 380 (24), pp. 2295-2306, 2019, ISSN: 0028-4793.

Abstract | Links:

Ho J, Sharma A, Kroeker K, Carroll R, De Serres S, Gibson IW, Hirt-Minkowski P, Jevnikar A, Kim SJ, Knoll G, Rush DN, Wiebe C, Nickerson P

Multicentre randomised controlled trial protocol of urine CXCL10 monitoring strategy in kidney transplant recipients.

Journal Article

BMJ Open, 9 (4), pp. e024908, 2019.

Abstract | Links:

Desjardins MP, Sidibe A, Fortier C, Mac-Way F, De Serres S, Lariviere R, Spronck B, Goupil R, Agharazii M

Impact of kidney transplantation on aortic stiffness and aortic stiffness index β0.

Journal Article

J Hypertens, 37 (7), pp. 1521-1528, 2019, ISSN: 0263-6352.

Abstract | Links:

Desy O, Beland S, Vallin P, Riopel J, Latulippe E, Wagner E, De Serres SA

Allogeneic dendritic cells stimulated with antibodies against HLA class II polarize naive T cells in a follicular helper phenotype.

Journal Article

Sci Rep, 8 (1), pp. 4025, 2018, ISSN: 2045-2322.

Abstract | Links:

Desy O, Beland S, Vallin P, Riopel J, Latulippe E, Najafian N, Chandraker A, Agharazii M, Batal I, De Serres SA

IL-6 production by monocytes is associated with graft function decline in patients with borderline changes suspicious for acute T-cell-mediated rejection: a pilot study.

Journal Article

Transpl Int, 31 (1), pp. 92-101, 2018, ISSN: 0934-0874.

Abstract | Links:

Desjardins MP, Sidibe A, Fortier C, Mac-Way F, Marquis K, De Serres S, Lariviere R, Agharazii M

Association of interleukin-6 with aortic stiffness in end-stage renal disease.

Journal Article

J Am Soc Hypertens, 12 (1), pp. 5-13, 2018, ISSN: 1933-1711.

Abstract | Links:

Vallin P, Desy O, Beland S, Bouchard-Boivin F, Houde I, De Serres SA

Impaired Secretion of TNF-α by Monocytes Stimulated With EBV Peptides Associates With Infectious Complications After Kidney Transplantation.

Journal Article

Transplantation, 102 (6), pp. 1005-1013, 2018, ISSN: 0041-1337.

Abstract | Links:

Batal I, Mohan S, De Serres SA, Vasilescu ER, Tsapepas D, Crew RJ, Patel SS, Serban G, McCune K, Husain SA, Chang JH, Herter JM, Bhagat G, Markowitz GS, D'Agati VD, Hardy MA, Ratner L, Chandraker A

Analysis of dendritic cells and ischemia-reperfusion changes in postimplantation renal allograft biopsies may serve as predictors of subsequent rejection episodes.

Journal Article

Kidney Int, 93 (5), pp. 1227-1239, 2018, ISSN: 0085-2538.

Abstract | Links:

54 entries « ‹ 1 of 6 › »
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Active projects

  • A randomized controlled effectiveness trial of urine CXCL10 chemokine monitoring post-renal transplant, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2016-07-01 to 2021-06-30
  • Aldosterone antagonism and enhanced Clearance for Health Improvement EValuation in End-stage renal disease (ACHIEVE) Trial, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2016-07-01 to 2022-06-30
  • Arterial stiffness gradient as a new index of vascular aging: impact of blood pressure lowering medication, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Development and validation of a cell-based assay to identify over-immunosuppression in kidney transplant recipients, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2023-09-30
  • Development and validation of a cellular assay to identify over-immunosupression in kidney transplants recipients, Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2019-07-01 to 2021-06-30
  • Mieux comprendre les mécanismes immunologiques du rejet chronique chez le greffé rénal afin d'améliorer le diagnostic et la prise en charge thérapeutique, Subvention, Fonds de recherche du Québec - Santé, Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, from 2018-07-01 to 2020-06-30
  • Precision Medicine CanPREVENT AMR: Applying Precision Medicine Technologies in Canada to Prevent Antibody Mediated Rejection and Premature Kidney Transplant Loss, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2018-04-01 to 2022-03-31
  • Rôle des cellules dendritiques dans l'immunologie de la transplantation., Subvention, Fondation de l'Université Laval, from 2015-01-01 to 2024-05-31

Recently finished projects

  • (FRSQ 78509)Perfectionnement de l'outil de surveillance immunitaire chez les patients greffés rénaux(validation des observations), Subvention, Fondation du CHU de Québec, from 2017-06-12 to 2018-06-11
  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
  • Évaluation du rôle de l’inflammation et des monocytes dans le développement du dommage de l’allogreffon en transplantation, Subvention, Fondation de l'Université Laval, from 2016-04-01 to 2018-04-30
  • The Role of Dendritic Cells and Follicular Helper T cells in Antibody-Mediated Rejection of the Kidney Graft, Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2017-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery