Dr. Sabine Elowe received her PhD from the University of Toronto in 2005, where she studied tyrosine kinase receptor signaling with Dr. Tony Pawson at the Lunenfeld-Tanenbaum Research Institute (formerly the Samuel Lunenfeld Research Institute). She then completed a postdoctoral internship at the Max Planck Institute of Biochemistry in Munich, Germany where she worked from 2005 to 2009 on the molecular mechanisms of cell division with Dr. Erich Nigg. She established her own laboratory at the CHU de Québec/Laval University in 2010. She is the recipient of numerous awards, including a CIHR New Investigator Salary Award, and FRQS Salary Awards.

The research

Aneuploidy is a pathological condition defined by an aberrant number of chromosomes. Dr. Elowe’s lab is interested in the characterization of signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy. Specifically, we are interested in a highly conserved kinase group known as the “Spinde Assembly Checkpoint” or “SAC” kinases, which collectively provides normal cell division by two distinct mechanisms: 1) ensuring the attachment of the chromosome to the cell division apparatus 2) delaying the division process until all elements of the division system are in position.

Our research focuses on the following questions:

  1. What are the mechanisms of activation and inactivation of SAC kinases?
  2. What are the endogenous substrates of SAC kinases?
  3. Is SAC differentially regulated in cell lines with chromosomal instability?
  4. How does aneuploidy contribute to cancer?

We will use a multidisciplinary approach to identify the signaling pathways involved, including RNA interference coupled with restoration approaches, mass spectrometry, generation and use of phospho-specific antibodies, indirect immunofluorescence, and high resolution video microscopy.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2
28 entries « 1 of 3 »

Paré G, Vitry J, Merchant ML, Vaillancourt M, Murru A, Shen Y, Elowe S, Lahoud MH, Naccache PH, McLeish KR, Fernandes MJ

The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release.

Journal Article

Front Immunol, 12 , 2021.

Abstract | Links:

Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, Gama-Braga L, Tribouillard L, Gagné A, Duchesne É, Caron D, Bérubé JS, Bérubé JC, Coulombe Y, Orain M, Gélinas Y, Gobeil S, Bossé Y, Masson JY, Elowe S, Bilodeau S, Manem V, Joubert P, Mallette FA, Laplante M

ZNF768 links oncogenic RAS to cellular senescence.

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Elowe S

Adventures of the undead at kinetochores.

Journal Article

Mol Cell Oncol, 8 (2), 2021.

Abstract | Links:

Prifti DK, Garand C, Saini PK, Elowe S, Gama Braga L

A quantitative and semiautomated method for determining misaligned and lagging chromosomes during mitosis.

Journal Article

Mol Biol Cell, 32 (9), 2021.

Abstract | Links:

Gama Braga L, Cisneros AF, Mathieu MM, Clerc M, Garcia P, Lottin B, Garand C, Thebault P, Landry CR, Elowe S

BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment.

Journal Article

Cell Rep, 33 (7), 2020.

Abstract | Links:

Dos Santos A, Elowe S

Moonlighting at the Centrosome: RXRα Turns to Plk1.

Journal Article

Dev Cell, 55 (6), 2020.

Abstract | Links:

Dou Z, Prifti DK, Gui P, Liu X, Elowe S, Yao X

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores.

Journal Article

Cells, 8 (3), 2019.

Abstract | Links:

Elowe S

Editorial: Novel Insights Into the Multifaceted Mitotic Kinases.

Journal Article

Front Cell Dev Biol, 7 , 2019.

| Links:

Jacquet K, Banerjee SL, Chartier FJM, Elowe S, Bisson N

Proteomic Analysis of NCK1/2 Adaptors Uncovers Paralog-specific Interactions That Reveal a New Role for NCK2 in Cell Abscission During Cytokinesis.

Journal Article

Mol Cell Proteomics, 17 (10), 2018.

Abstract | Links:

Boutchueng-Djidjou M, Belleau P, Bilodeau N, Fortier S, Bourassa S, Droit A, Elowe S, Faure RL

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes.

Journal Article

PLoS One, 13 (10), 2018.

Abstract | Links:

28 entries « 1 of 3 »
Signaler des ajouts ou des modifications

Active projects

  • Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, from 2020-07-01 to 2024-06-30
  • Phosphotyrosine signalling during mitosis., from 2016-04-01 to 2022-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2022-03-31
  • Regulation of chromosome cohesion and genome stability by a novel Histone modification, from 2018-04-01 to 2023-03-31
  • Towards a comprehensive model of Spindle Assembly Checkpoint silencing, from 2017-04-01 to 2022-03-31

Recently finished projects

  • Analyse protéomique des réseaux de signalisation dépendants des récepteurs tyrosine kinase de la famille EPH et de leurs fonctions dans la ségrégation cellulaire et la polarité épitheliale, from 2018-04-01 to 2021-03-31
  • Exploring the functions of the Bub1 and BubR1 kinases during mitosis., from 2011-10-01 to 2020-03-31
  • High throughput analysis of protein interactions and modifications using peptide arrays, from 2019-03-28 to 2020-03-31
  • Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, from 2017-07-01 to 2020-06-30
Data provided by the Université Laval research projects registery