Dr. Sabine Elowe received her PhD from the University of Toronto in 2005, where she studied tyrosine kinase receptor signaling with Dr. Tony Pawson at the Lunenfeld-Tanenbaum Research Institute (formerly the Samuel Lunenfeld Research Institute). She then completed a postdoctoral internship at the Max Planck Institute of Biochemistry in Munich, Germany where she worked from 2005 to 2009 on the molecular mechanisms of cell division with Dr. Erich Nigg. She established her own laboratory at the CHU de Québec/Laval University in 2010. She is the recipient of numerous awards, including a CIHR New Investigator Salary Award, and FRQS Salary Awards.

The research

Aneuploidy is a pathological condition defined by an aberrant number of chromosomes. Dr. Elowe’s lab is interested in the characterization of signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy. Specifically, we are interested in a highly conserved kinase group known as the “Spinde Assembly Checkpoint” or “SAC” kinases, which collectively provides normal cell division by two distinct mechanisms: 1) ensuring the attachment of the chromosome to the cell division apparatus 2) delaying the division process until all elements of the division system are in position.

Our research focuses on the following questions:

  1. What are the mechanisms of activation and inactivation of SAC kinases?
  2. What are the endogenous substrates of SAC kinases?
  3. Is SAC differentially regulated in cell lines with chromosomal instability?
  4. How does aneuploidy contribute to cancer?

We will use a multidisciplinary approach to identify the signaling pathways involved, including RNA interference coupled with restoration approaches, mass spectrometry, generation and use of phospho-specific antibodies, indirect immunofluorescence, and high resolution video microscopy.

CHUL
2705, boulevard Laurier
T-3-67
Québec, Québec
Canada G1V 4G2
18 entries « 1 of 4 »

Combes G, Barysz H, Garand C, Gama Braga L, Alharbi I, Thebault P, Murakami L, Bryne DP, Stankovic S, Eyers PA, Bolanos-Garcia VM, Earnshaw WC, Maciejowski J, Jallepalli PV, Elowe S

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.

Journal Article

Curr Biol, 28 (6), pp. 872-883.e5, 2018, ISSN: 0960-9822.

Abstract | Links:

Combes G, Alharbi I, Braga LG, Elowe S

Playing polo during mitosis: PLK1 takes the lead.

Journal Article

Oncogene, 36 (34), pp. 4819-4827, 2017, ISSN: 0950-9232.

Abstract | Links:

Elowe S

Tyr(less) kinase signaling during mitosis.

Journal Article

Cell Cycle, 16 (8), pp. 746-748, 2017, ISSN: 1538-4101.

Abstract | Links:

Caron D, Byrne DP, Thebault P, Soulet D, Landry CR, Eyers PA, Elowe S

Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1).

Journal Article

Sci Signal, 9 (458), pp. rs14, 2016.

Abstract | Links:

Fuchs M, Luthold C, Guilbert SM, Varlet AA, Lambert H, Jette A, Elowe S, Landry J, Lavoie JN

A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis.

Journal Article

PLoS Genet, 11 (10), pp. e1005582, 2015, ISSN: 1553-7390.

Abstract | Links:

18 entries « 1 of 4 »

Active projects

  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Exploring the functions of the Bub1 and BubR1 kinases during mitosis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2011-10-01 to 2020-03-31
  • Investigating a potential role for the microtubule stabilizing protein Tau in cancer, Subvention, Fondation de l'Université Laval, from 2016-09-15 to 2018-09-14
  • Les kinases mitotiques et la régulation de l'aneuploïdie et cancer, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2017-07-01 to 2020-06-30
  • Phosphotyrosine signalling during mitosis., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
  • Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2014-05-01 to 2020-04-30
  • Regulation of chromosome cohesion and genome stability by a novel Histone modification, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Towards a comprehensive model of Spindle Assembly Checkpoint silencing, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31

Recently finished projects

  • Bench fees for Ibrahim Aiyedh S Alharbi, Subvention, Saudi Arabian Cultural Bureau, from 2017-02-01 to 2018-01-31
  • Exploring the functions of the Bub1 and BubR1 kinases during mitosis., Subvention, Instituts de recherche en santé du Canada, Bourse salariale pour nouveau chercheur, from 2012-07-01 to 2017-06-30
  • Exploring the role of the spindle checkpoint kinase Mps1 in maintaining genome stability., Subvention, Société de recherche sur le cancer, Subvention de fonctionnement, from 2014-09-01 to 2016-08-31
  • Le rôle des kinases mitotiques Bub1 et BubR1 dans la prévention de l'instabilité chromosomique, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2012-07-01 to 2016-06-30
  • Le rôle des kinases mitotiques Bub1 et BubR1 dans la prévention de l'instabilité chromosomique, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2012-07-01 to 2016-06-30
Data provided by the Université Laval research projects registery