Robert Viger, PhD, is a researcher and regular member of the Centre de recherche du CHU de Québec-Laval University, and Professor in the Department of Obstetrics, Gynecology, and Reproduction at the Laval University School of Medicine. At Laval University, Professor Viger has also been Scientific Director of the Centre de recherche en reproduction, développement et santé intergénérationnelle (CRDSI), since 2014. His laboratory is presently investigating the molecular and genetic pathways involved in early gonadal differentiation, the regulation of gonad-specific gene expression, and the control of gonadal physiology. His research has been continuously funded by the Canadian Institutes of Health Research (CIHR), since 1998. From 2002 to 2012, he held the Tier 2 Canada Research Chair in Reproduction and Sex Development.
Understanding, preventing, and treating problems related to reproductive health
Reproductive dysfunction is a common medical condition. Problems range from differences in the sex determination and differentiation pathways to male and female infertility. Research in these areas is therefore essential to better understand, diagnose, treat, and hopefully prevent these problems that can be devastating for many individuals and couples. His laboratory seeks to understand the molecular and genetic mechanisms involved in human and animal reproduction in both health and disease. His goal is to provide the necessary groundwork for developing novel therapies that can eventually be used to improve reproductive health, and therefore the quality of life of those affected.
His laboratory is specifically interested in defining the transcriptional regulatory pathways that are involved in establishing mammalian sex determination (i.e., the formation of a testis or an ovary) and sex differentiation (i.e., the development of internal and external genitalia, and therefore the male or female phenotype). Over the past several years, his research has also brought new insights into our understanding of several pathologies that affect women’s health such as breast cancer, endometriosis, and polycystic ovary syndrome.
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Protein kinase A-dependent synergism between GATA factors and the nuclear receptor, liver receptor homolog-1, regulates human aromatase (CYP19) PII promoter activity in breast cancer cells.Journal Article
Endocrinology, 146 (11), pp. 4905-16, 2005, ISSN: 0013-7227.
GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter.Journal Article
Mol Endocrinol, 19 (9), pp. 2358-70, 2005, ISSN: 0888-8809.
New insights into the regulation of mammalian sex determination and male sex differentiation.Journal Article
Vitam Horm, 70 , pp. 387-413, 2005, ISSN: 0083-6729.
Genes and gene defects affecting gonadal development and sex determination.Book Chapter
L, Martini (Ed.): Encyclopedia of endocrine diseases, 2 , pp. 135-140, Amsterdam, Elsevier, 2004, ISBN: 0124755720.
Role of the GATA family of transcription factors in andrology.Journal Article
J Androl, 25 (4), pp. 441-52, 2004, ISSN: 0196-3635.
A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4.Journal Article
J Biol Chem, 278 (43), pp. 42637-42, 2003, ISSN: 0021-9258.
Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells.Journal Article
J Biol Chem, 278 (24), pp. 22128-35, 2003, ISSN: 0021-9258.
Novel roles for GATA transcription factors in the regulation of steroidogenesis.Journal Article
J Steroid Biochem Mol Biol, 85 (2-5), pp. 291-8, 2003, ISSN: 0960-0760.
Porcine SRY promoter is a target for steroidogenic factor 1.Journal Article
Biol Reprod, 68 (4), pp. 1098-106, 2003, ISSN: 0006-3363.
Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity.Journal Article
Endocrinology, 143 (10), pp. 3935-45, 2002, ISSN: 0013-7227.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-02-02
- Réseau Québécois en Reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31
- Sex, hormones, and fertility: elucidating the molecular mechanism of action of transcription factor GATA4 in reproductive function, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2024-09-30
Recently finished projects
- Nouvelles cibles moléculaires dans le but d'améliorer la fonction ovarienne chez la vache laitière, Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2017-04-01 to 2020-03-31