Robert Viger, PhD, is a researcher and regular member of the Centre de recherche du CHU de Québec-Laval University, and Professor in the Department of Obstetrics, Gynecology, and Reproduction at the Laval University School of Medicine. At Laval University, Professor Viger has also been Scientific Director of the Centre de recherche en reproduction, développement et santé intergénérationnelle (CRDSI), since 2014. His laboratory is presently investigating the molecular and genetic pathways involved in early gonadal differentiation, the regulation of gonad-specific gene expression, and the control of gonadal physiology. His research has been continuously funded by the Canadian Institutes of Health Research (CIHR), since 1998. From 2002 to 2012, he held the Tier 2 Canada Research Chair in Reproduction and Sex Development.

Understanding, preventing, and treating problems related to reproductive health

Reproductive dysfunction is a common medical condition. Problems range from differences in the sex determination and differentiation pathways to male and female infertility. Research in these areas is therefore essential to better understand, diagnose, treat, and hopefully prevent these problems that can be devastating for many individuals and couples. His laboratory seeks to understand the molecular and genetic mechanisms involved in human and animal reproduction in both health and disease. His goal is to provide the necessary groundwork for developing novel therapies that can eventually be used to improve reproductive health, and therefore the quality of life of those affected.

His laboratory is specifically interested in defining the transcriptional regulatory pathways that are involved in establishing mammalian sex determination (i.e., the formation of a testis or an ovary) and sex differentiation (i.e., the development of internal and external genitalia, and therefore the male or female phenotype). Over the past several years, his research has also brought new insights into our understanding of several pathologies that affect women’s health such as breast cancer, endometriosis, and polycystic ovary syndrome.

CHUL
2705, boulevard Laurier
T-3-67
Québec, Québec
Canada G1V 4G2
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Mehanovic S, Mendoza-Villarroel RE, Mattos K, Talbot P, Viger RS, Tremblay JJ

Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells†.

Journal Article

Biol Reprod, 2021.

Abstract | Links:

Leszczyński P, Śmiech M, Salam Teeli A, Haque E, Viger R, Ogawa H, Pierzchała M, Taniguchi H

Deletion of the Gene Causes a Neuronal Differentiation Deficiency in P19 Cells.

Journal Article

Int J Mol Sci, 21 (19), 2020.

Abstract | Links:

Mehanovic S, Mendoza-Villarroel RE, Viger RS, Tremblay JJ

The Nuclear Receptor COUP-TFII Regulates Gene Transcription via a GC-Rich Promoter Element in Mouse Leydig Cells.

Journal Article

J Endocr Soc, 3 (12), 2019.

Abstract | Links:

Bergeron F, Boulende Sab A, Bouchard MF, Taniguchi H, Souchkova O, Brousseau C, Tremblay JJ, Pilon N, Viger RS

Phosphorylation of GATA4 serine 105 but not serine 261 is required for testosterone production in the male mouse.

Journal Article

Andrology, 7 (3), 2019.

Abstract | Links:

Bouchard MF, Bergeron F, Grenier Delaney J, Harvey LM, Viger RS

In Vivo Ablation of the Conserved GATA-Binding Motif in the Amh Promoter Impairs Amh Expression in the Male Mouse.

Journal Article

Endocrinology, 160 (4), 2019.

Abstract | Links:

George RM, Hahn KL, Rawls A, Viger R, Wilson-Rawls J

Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis.

Journal Article

Reproduction, 150 (4), 2015.

Abstract | Links:

Bergeron F, Nadeau G, Viger R

GATA4 knockdown in MA-10 Leydig cells identifies multiple target genes in the steroidogenic pathway.

Journal Article

Reproduction, 149 (3), 2015.

Abstract | Links:

Mazaud-Guittot S, Prud'homme B, Bouchard MF, Bergeron F, Daems C, Tevosian SG, Viger RS

GATA4 autoregulates its own expression in mouse gonadal cells via its distal 1b promoter.

Journal Article

Biol Reprod, 90 (2), 2014.

Abstract | Links:

Martin LJ, Bergeron F, Viger RS, Tremblay JJ

Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells.

Journal Article

J Androl, 33 (1), 2012.

Abstract | Links:

Silversides DW, Raiwet DL, Souchkova O, Viger RS, Pilon N

Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage.

Journal Article

Dev Dyn, 241 (7), 2012.

Abstract | Links:

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Active projects

  • Importance des protéines reliées au syndrome X-Fragile dans les fonctions reproductives masculines, from 2020-12-16 to 2021-12-31
  • Réseau Québécois en Reproduction (RQR), from 2017-04-01 to 2023-03-31
  • Sex, hormones, and fertility: elucidating the molecular mechanism of action of transcription factor GATA4 in reproductive function, from 2019-10-01 to 2024-09-30

Recently finished projects

  • Nouvelles cibles moléculaires dans le but d'améliorer la fonction ovarienne chez la vache laitière, from 2017-04-01 to 2020-03-31
Data provided by the Université Laval research projects registery