Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.
Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.
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Modulation of interferon-gamma-induced macrophage activation by phosphotyrosine phosphatases inhibition. Effect on murine Leishmaniasis progression.Journal Article
J Biol Chem, 273 (22), pp. 13944-9, 1998, ISSN: 0021-9258.
Characterization of a 54-kilodalton human protein kinase recognized by an antiserum raised against the myotonin kinase.Journal Article
Muscle Nerve, 21 (1), pp. 8-17, 1998, ISSN: 0148-639X.
Activation of HIV-1 long terminal repeat transcription and virus replication via NF-kappaB-dependent and -independent pathways by potent phosphotyrosine phosphatase inhibitors, the peroxovanadium compounds.Journal Article
J Biol Chem, 272 (20), pp. 12968-77, 1997, ISSN: 0021-9258.
Interaction of sodium molybdate with the thyroid hormone receptor.Journal Article
Biochem Cell Biol, 68 (3), pp. 630-4, 1990, ISSN: 0829-8211.
Effects of adenosine triphosphate and alkaline phosphatase on solubilized 3,5,3'-triiodothyronine-binding activity.Journal Article
Endocrinology, 123 (3), pp. 1245-52, 1988, ISSN: 0013-7227.
A monoclonal antibody to the rat nuclear triiodothyronine receptor: production and characterization.Journal Article
Endocrinology, 123 (1), pp. 180-6, 1988, ISSN: 0013-7227.
Production of an antibody against rat liver nuclear T3 receptor.Journal Article
Biochem Cell Biol, 64 (4), pp. 377-80, 1986, ISSN: 0829-8211.
Regional distribution of nuclear T3 receptors in rat brain and evidence for preferential localization in neurons.Journal Article
J Endocrinol Invest, 8 (4), pp. 343-8, 1985, ISSN: 0391-4097.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
Recently finished projects
- Investigation du module de maladie du diabète de type 2 , Subvention, Fondation du CHU de Québec, from 2019-11-14 to 2020-03-31