Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.

Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.

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38 entries « 4 of 4 »

Olivier M, Romero-Gallo BJ, Matte C, Blanchette J, Posner BI, Tremblay MJ, Faure R

Modulation of interferon-gamma-induced macrophage activation by phosphotyrosine phosphatases inhibition. Effect on murine Leishmaniasis progression.

Journal Article

J Biol Chem, 273 (22), pp. 13944-9, 1998, ISSN: 0021-9258.

Abstract | Links:

Etongué-Mayer P, Faure R, Bouchard JP, Puymirat J

Characterization of a 54-kilodalton human protein kinase recognized by an antiserum raised against the myotonin kinase.

Journal Article

Muscle Nerve, 21 (1), pp. 8-17, 1998, ISSN: 0148-639X.

Abstract | Links:

Barbeau B, Bernier R, Dumais N, Briand G, Olivier M, Faure R, Posner BI, Tremblay M

Activation of HIV-1 long terminal repeat transcription and virus replication via NF-kappaB-dependent and -independent pathways by potent phosphotyrosine phosphatase inhibitors, the peroxovanadium compounds.

Journal Article

J Biol Chem, 272 (20), pp. 12968-77, 1997, ISSN: 0021-9258.

Abstract | Links:

Faure R, Dussault JH

Interaction of sodium molybdate with the thyroid hormone receptor.

Journal Article

Biochem Cell Biol, 68 (3), pp. 630-4, 1990, ISSN: 0829-8211.

Abstract | Links:

Faure R, Dussault JH

Effects of adenosine triphosphate and alkaline phosphatase on solubilized 3,5,3'-triiodothyronine-binding activity.

Journal Article

Endocrinology, 123 (3), pp. 1245-52, 1988, ISSN: 0013-7227.

Abstract | Links:

Luo M, Faure R, Ruel J, Dussault JH

A monoclonal antibody to the rat nuclear triiodothyronine receptor: production and characterization.

Journal Article

Endocrinology, 123 (1), pp. 180-6, 1988, ISSN: 0013-7227.

Abstract | Links:

Faure R, Ruel J, Dussault JH

Production of an antibody against rat liver nuclear T3 receptor.

Journal Article

Biochem Cell Biol, 64 (4), pp. 377-80, 1986, ISSN: 0829-8211.

Abstract | Links:

Ruel J, Faure R, Dussault JH

Regional distribution of nuclear T3 receptors in rat brain and evidence for preferential localization in neurons.

Journal Article

J Endocrinol Invest, 8 (4), pp. 343-8, 1985, ISSN: 0391-4097.

Abstract | Links:

38 entries « 4 of 4 »
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