Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.

Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.

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38 entries « 2 of 4 »

Bilodeau N, Fiset A, Boulanger MC, Bhardwaj S, Winstall E, Lavoie JN, Faure RL

Proteomic analysis of Src family kinases signaling complexes in Golgi/endosomal fractions using a site-selective anti-phosphotyrosine antibody: identification of LRP1-insulin receptor complexes.

Journal Article

J Proteome Res, 9 (2), pp. 708-17, 2010, ISSN: 1535-3893.

Abstract | Links:

Caron D, Winstall E, Inaguma Y, Michaud S, Lettre F, Bourassa S, Kelly I, Poirier GG, Faure RL, Tanguay RM

Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulated.

Journal Article

J Proteome Res, 7 (10), pp. 4492-9, 2008, ISSN: 1535-3893.

Abstract | Links:

Caron D, Savard PE, Doillon CJ, Olivier M, Shink E, Lussier JG, Faure RL

Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells.

Journal Article

Cancer Lett, 262 (2), pp. 265-75, 2008, ISSN: 0304-3835.

Abstract | Links:

Lalancette C, Faure RL, Leclerc P

Identification of the proteins present in the bull sperm cytosolic fraction enriched in tyrosine kinase activity: a proteomic approach.

Journal Article

Proteomics, 6 (16), pp. 4523-40, 2006, ISSN: 1615-9853.

Abstract | Links:

Durocher F, Faure R, Labrie Y, Pelletier L, Bouchard I, Laframboise R

A novel mutation in the EIF2AK3 gene with variable expressivity in two patients with Wolcott-Rallison syndrome.

Journal Article

Clin Genet, 70 (1), pp. 34-8, 2006, ISSN: 0009-9163.

Abstract | Links:

Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournès B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A

The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.

Journal Article

Nat Med, 12 (5), pp. 549-56, 2006, ISSN: 1078-8956.

Abstract | Links:

Lalancette C, Bordeleau LJ, Faure RL, Leclerc P

Bull testicular haploid germ cells express a messenger encoding for a truncated form of the protein tyrosine kinase HCK.

Journal Article

Mol Reprod Dev, 73 (4), pp. 520-30, 2006, ISSN: 1040-452X.

Abstract | Links:

Bilodeau N, Fiset A, Poirier GG, Fortier S, Gingras MC, Lavoie JN, Faure RL

Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src.

Journal Article

FEBS J, 273 (5), pp. 992-1003, 2006, ISSN: 1742-464X.

Abstract | Links:

Brûlé S, Faure R, Doré M, Silversides DW, Lussier JG

Immunolocalization of vacuolar system-associated protein-60 (VASAP-60).

Journal Article

Histochem Cell Biol, 119 (5), pp. 371-81, 2003, ISSN: 0948-6143.

Abstract | Links:

Bilodeau JF, Patenaude A, Piedboeuf B, Carrier C, Petrov P, Faure R, Mirault ME

Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest.

Journal Article

Free Radic Biol Med, 33 (9), pp. 1279-89, 2002, ISSN: 0891-5849.

Abstract | Links:

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  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
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