Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.
Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.
2705, boulevard Laurier
Canada G1V 4G2
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Proteomic analysis of Src family kinases signaling complexes in Golgi/endosomal fractions using a site-selective anti-phosphotyrosine antibody: identification of LRP1-insulin receptor complexes.Journal Article
J Proteome Res, 9 (2), pp. 708-17, 2010, ISSN: 1535-3893.
Proteomic characterization of mouse cytosolic and membrane prostate fractions: high levels of free SUMO peptides are androgen-regulated.Journal Article
J Proteome Res, 7 (10), pp. 4492-9, 2008, ISSN: 1535-3893.
Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells.Journal Article
Cancer Lett, 262 (2), pp. 265-75, 2008, ISSN: 0304-3835.
Identification of the proteins present in the bull sperm cytosolic fraction enriched in tyrosine kinase activity: a proteomic approach.Journal Article
Proteomics, 6 (16), pp. 4523-40, 2006, ISSN: 1615-9853.
A novel mutation in the EIF2AK3 gene with variable expressivity in two patients with Wolcott-Rallison syndrome.Journal Article
Clin Genet, 70 (1), pp. 34-8, 2006, ISSN: 0009-9163.
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.Journal Article
Nat Med, 12 (5), pp. 549-56, 2006, ISSN: 1078-8956.
Bull testicular haploid germ cells express a messenger encoding for a truncated form of the protein tyrosine kinase HCK.Journal Article
Mol Reprod Dev, 73 (4), pp. 520-30, 2006, ISSN: 1040-452X.
Insulin-dependent phosphorylation of DPP IV in liver. Evidence for a role of compartmentalized c-Src.Journal Article
FEBS J, 273 (5), pp. 992-1003, 2006, ISSN: 1742-464X.
Immunolocalization of vacuolar system-associated protein-60 (VASAP-60).Journal Article
Histochem Cell Biol, 119 (5), pp. 371-81, 2003, ISSN: 0948-6143.
Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest.Journal Article
Free Radic Biol Med, 33 (9), pp. 1279-89, 2002, ISSN: 0891-5849.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
Recently finished projects
- Investigation du module de maladie du diabète de type 2 , Subvention, Fondation du CHU de Québec, from 2019-11-14 to 2020-03-31