Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.
Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.
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Network medicine-travelling with the insulin receptor: Encounter of the second type.Journal Article
EClinicalMedicine, 13 , pp. 14-20, 2019, ISSN: 2589-5370.
A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes.Journal Article
PLoS ONE, 13 (10), pp. e0205180, 2018.
Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulin.Journal Article
FEBS Lett, 589 (9), pp. 985-91, 2015, ISSN: 0014-5793.
The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.Journal Article
Mol Cell Proteomics, 14 (4), pp. 1079-92, 2015, ISSN: 1535-9476.
Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation.Journal Article
Cell Signal, 25 (10), pp. 1962-9, 2013, ISSN: 0898-6568.
Preclinical evaluation of dipotassium bisperoxo (picolinato) oxovanadate V for the treatment of pediatric low-grade gliomas.Journal Article
Future Oncol, 9 (8), pp. 1215-29, 2013, ISSN: 1479-6694.
Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling.Journal Article
Exp Cell Res, 319 (4), pp. 474-86, 2013, ISSN: 0014-4827.
Proteomic analysis identifies new biomarkers for postmenopausal and dry skin.Journal Article
Exp Dermatol, 21 (3), pp. 205-10, 2012, ISSN: 0906-6705.
Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization.Journal Article
Cell Signal, 23 (5), pp. 911-9, 2011, ISSN: 0898-6568.
Src-family kinase signaling, actin-mediated membrane trafficking and organellar dynamics in the control of cell fate: lessons to be learned from the adenovirus E4orf4 death factor.Journal Article
Cell Signal, 22 (11), pp. 1604-14, 2010, ISSN: 0898-6568.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
Recently finished projects
- Investigation du module de maladie du diabète de type 2 , Subvention, Fondation du CHU de Québec, from 2019-11-14 to 2020-03-31