Dr. Robert Faure Ph.D.’s group is located at the Research Center of CHU Quebec, CHUL Centre-Mère-Enfant-Soleil. He is a full professor in the Department of Pediatrics of the Faculty of Medicine at Laval University.

Dr Faure studied the spatial and temporal insulin receptor signaling. He recently established a proteome of endosomes that allowed the study of physical protein interaction networks in a type 2 diabetes mellitus background. The resulting interactome is dense, organized around major hubs and highly enriched with genes associated with the type 2 diabetes genetic risk, defining a type 2 diabetes disease module. This module is formed by new signaling mechanisms that are largely unrelated to canonical insulin signaling pathways. It represents a valuable new resource that provides a mechanistic rationale for the exploration of personalized medicine and necessary drugs.

CHUL
2705, boulevard Laurier
T3-67
Québec, Québec
Canada G1V 4G2

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Boutchueng-Djidjou M, Faure RL

Network medicine-travelling with the insulin receptor: Encounter of the second type.

Journal Article

EClinicalMedicine, 13 , 2019.

Abstract | Links:

Boutchueng-Djidjou M, Belleau P, Bilodeau N, Fortier S, Bourassa S, Droit A, Elowe S, Faure RL

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes.

Journal Article

PLoS One, 13 (10), 2018.

Abstract | Links:

Boutchueng-Djidjou M, Collard-Simard G, Fortier S, Hebert SS, Kelly I, Landry CR, Faure RL

The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

Journal Article

Mol Cell Proteomics, 14 (4), 2015.

Abstract | Links:

Caron D, Boutchueng-Djidjou M, Tanguay RM, Faure RL

Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulin.

Journal Article

FEBS Lett, 589 (9), 2015.

Abstract | Links:

Ajeawung NF, Faure R, Jones C, Kamnasaran D

Preclinical evaluation of dipotassium bisperoxo (picolinato) oxovanadate V for the treatment of pediatric low-grade gliomas.

Journal Article

Future Oncol, 9 (8), 2013.

Abstract | Links:

Mathew J, Loranger A, Gilbert S, Faure R, Marceau N

Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling.

Journal Article

Exp Cell Res, 319 (4), 2013.

Abstract | Links:

Caron D, Maaroufi H, Michaud S, Tanguay RM, Faure RL

Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation.

Journal Article

Cell Signal, 25 (10), 2013.

Abstract | Links:

Delattre C, Winstall E, Lessard C, Donovan M, Simonetti L, Minondo AM, Faure R, Calvo E, Coutet J, Verschoore M, Chaussade V, Castiel-Higounenc I, Labrie F, Leclaire J, Bernard D

Proteomic analysis identifies new biomarkers for postmenopausal and dry skin.

Journal Article

Exp Dermatol, 21 (3), 2012.

Abstract | Links:

Fiset A, Xu E, Bergeron S, Marette A, Pelletier G, Siminovitch KA, Olivier M, Beauchemin N, Faure RL

Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization.

Journal Article

Cell Signal, 23 (5), 2011.

Abstract | Links:

Bilodeau N, Fiset A, Boulanger MC, Bhardwaj S, Winstall E, Lavoie JN, Faure RL

Proteomic analysis of Src family kinases signaling complexes in Golgi/endosomal fractions using a site-selective anti-phosphotyrosine antibody: identification of LRP1-insulin receptor complexes.

Journal Article

J Proteome Res, 9 (2), 2010.

Abstract | Links:

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Recently finished projects

  • Investigation du module de maladie du diabète de type 2 , from 2019-11-14 to 2020-03-31
Data provided by the Université Laval research projects registery