Dr. Laforce obtained his PhD in Clinical Neuropsychology in 1998 and worked as an Assistant Professor in Cognitive Neurosciences before completing his studies in Behavioral Neurology in 2011. He performed a Fellowship in frontotemporal dementia under Dr. Bruce Miller at the Memory and Aging Center, University of California San Francisco. He conducted brain imaging studies using FEG-PET and amyloid PET with Dr. Gil Rabinovici (University of California, Berkeley). He has been the co-leader of the Neurology class at the Laval University Faculty of Medicine, since 2012. He is a Clinician and Researcher in the CHU de Québec research center, member of the C5R (Consortium of Canadian Centres for Clinical Cognitive Research), RQRV (Réseau Québécois de Recherche sur le Vieillissement), and CINQ (Consortium d’Imagerie en Neurosciences et santé mentale de Québec). Dr. Laforce obtained several major grants (CIHR, Weston Brain Institute, RMGA), presented at national and international meetings, published over 100 scientific papers in prestigious journals such as Lancet Neurology, Brain, Neurology, Neuroimage, Alzheimer Research and Therapy. He wrote a book on memory as well as book chapters. Dr. Laforce is one of the Principal Investigators in the great international endeavours GENFI (Genetic Frontotemporal Dementia Initiative) and DIAN (Dominantly Inherited Alzheimer Network). He leads several research projects on the development of cognitive tools (www.dcqtest.org et www.quoco.org) and the clinical utility of molecular imaging such as FDG-PET and amyloid PET in the differential diagnosis of atypical dementias.

1401, 18e Rue
Clinique Interdisciplinaire de Mémoire
9
Québec, Québec
Canada G1J 1Z4
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Leijenaar JF, Groot C, Sudre CH, Bergeron D, Leeuwis AE, Cardoso MJ, Carrasco FP, Laforce R Jr, Barkhof F, van der Flier WM, Scheltens P, Prins ND, Ossenkoppele R

Comorbid amyloid-β pathology affects clinical and imaging features in VCD.

Journal Article

Alzheimers Dement, 16 (2), pp. 354-364, 2020, ISSN: 1552-5260.

Abstract | Links:

van der Ende EL, Meeter LH, Poos JM, Panman JL, Jiskoot LC, Dopper EGP, Papma JM, de Jong FJ, Verberk IMW, Teunissen C, Rizopoulos D, Heller C, Convery RS, Moore KM, Bocchetta M, Neason M, Cash DM, Borroni B, Galimberti D, Sanchez-Valle R, Laforce R Jr, Moreno F, Synofzik M, Graff C, Masellis M, Carmela Tartaglia M, Rowe JB, Vandenberghe R, Finger E, Tagliavini F, de Mendonca A, Santana I, Butler C, Ducharme S, Gerhard A, Danek A, Levin J, Otto M, Frisoni GB, Cappa S, Pijnenburg YAL, Rohrer JD, van Swieten JC, Genetic Frontotemporal dementia Initiative (GENFI)

Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study.

Journal Article

Lancet Neurol, 18 (12), pp. 1103-1111, 2019, ISSN: 1474-4422.

Abstract | Links:

Tavares TP, Mitchell DGV, Coleman K, Shoesmith C, Bartha R, Cash DM, Moore KM, van Swieten J, Borroni B, Galimberti D, Tartaglia MC, Rowe J, Graff C, Tagliavini F, Frisoni G, Cappa S, Laforce R Jr, de Mendonca A, Sorbi S, Wallstrom G, Masellis M, Rohrer JD, Finger EC, Genetic FTD Initiative, GENFI

Ventricular volume expansion in presymptomatic genetic frontotemporal dementia.

Journal Article

Neurology, 93 (18), pp. e1699-e1706, 2019, ISSN: 0028-3878.

Abstract | Links:

Zukotynski K, Gaudet V, Kuo PH, Adamo S, Goubran M, Scott C, Bocti C, Borrie M, Chertkow H, Frayne R, Hsiung R, Laforce R Jr, Noseworthy MD, Prato FS, Sahlas DJ, Smith EE, Sossi V, Thiel A, Soucy JP, Tardif JC, Black SE

The Use of Random Forests to Classify Amyloid Brain PET.

Journal Article

Clin Nucl Med, 44 (10), pp. 784-788, 2019, ISSN: 0363-9762.

Abstract | Links:

Premi E, Calhoun VD, Diano M, Gazzina S, Cosseddu M, Alberici A, Archetti S, Paternico D, Gasparotti R, van Swieten J, Galimberti D, Sanchez-Valle R, Laforce R Jr, Moreno F, Synofzik M, Graff C, Masellis M, Tartaglia MC, Rowe J, Vandenberghe R, Finger E, Tagliavini F, de Mendonca A, Santana I, Butler C, Ducharme S, Gerhard A, Danek A, Levin J, Otto M, Frisoni G, Cappa S, Sorbi S, Padovani A, Rohrer JD, Borroni B, Genetic FTD Initiative, GENFI

The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.

Journal Article

Neuroimage, 189 , pp. 645-654, 2019, ISSN: 1053-8119.

Abstract | Links:

Mutsaerts HJMM, Mirza SS, Petr J, Thomas DL, Cash DM, Bocchetta M, de Vita E, Metcalfe AWS, Shirzadi Z, Robertson AD, Tartaglia MC, Mitchell SB, Black SE, Freedman M, Tang-Wai D, Keren R, Rogaeva E, van Swieten J, Laforce R, Tagliavini F, Borroni B, Galimberti D, Rowe JB, Graff C, Frisoni GB, Finger E, Sorbi S, de Mendonca A, Rohrer JD, MacIntosh BJ, Masellis M, GENFI consortium

Cerebral perfusion changes in presymptomatic genetic frontotemporal dementia: a GENFI study.

Journal Article

Brain, 142 (4), pp. 1108-1120, 2019, ISSN: 0006-8950.

Abstract | Links:

van der Ende EL, Meeter LH, Stingl C, van Rooij JGJ, Stoop MP, Nijholt DAT, Sanchez-Valle R, Graff C, Oijerstedt L, Grossman M, McMillan C, Pijnenburg YAL, Laforce R Jr, Binetti G, Benussi L, Ghidoni R, Luider TM, Seelaar H, van Swieten JC

Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics.

Journal Article

Ann Clin Transl Neurol, 6 (4), pp. 698-707, 2019, ISSN: 2328-9503.

Abstract | Links:

Lavoie M, Bier N, Laforce R Jr, Macoir J

Improvement in functional vocabulary and generalization to conversation following a self-administered treatment using a smart tablet in primary progressive aphasia.

Journal Article

Neuropsychol Rehabil, pp. 1-31, 2019, ISSN: 0960-2011.

Abstract | Links:

Cury C, Durrleman S, Cash DM, Lorenzi M, Nicholas JM, Bocchetta M, van Swieten JC, Borroni B, Galimberti D, Masellis M, Tartaglia MC, Rowe JB, Graff C, Tagliavini F, Frisoni GB, Laforce R Jr, Finger E, de Mendonca A, Sorbi S, Ourselin S, Rohrer JD, Modat M, Genetic FTD Initiative, GENFI

Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort.

Journal Article

Neuroimage, 188 , pp. 282-290, 2019, ISSN: 1053-8119.

Abstract | Links:

Macoir J, Hudon C, Tremblay MP, Laforce RJ, Wilson MA

The contribution of semantic memory to the recognition of basic emotions and emotional valence: Evidence from the semantic variant of primary progressive aphasia.

Journal Article

Soc Neurosci, 14 (6), pp. 705-716, 2019, ISSN: 1747-0919.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
  • Phase Two of the Canadian Consortium on Neurodegeneration in Aging, Subvention, Instituts de recherche en santé du Canada, Consortium canadien en neurodégénérescence et vieillissement (CCNV), from 2019-04-01 to 2024-03-31

Recently finished projects

  • Canadian Consortium on Neurodegeneration in Aging - Full proposal, Subvention, Instituts de recherche en santé du Canada, Consortium canadien en neurodégénérescence et vieillissement (CCNV), from 2014-04-01 to 2019-03-31
  • Étude du métabolisme cérébral chez les porteurs asymptomatiques d'une mutation MAPT : une sous-étude GENFI, Subvention, Société Alzheimer de Québec, from 2017-11-07 to 2018-11-06
  • Genetic Frontotemporal dementia Initiative (GENFI), Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-06-30
  • IUCPQ application for Core Clinical Center for CTSN network, Subvention, National Institute of Health (USA), Centres cliniques principaux pour le Réseau d’essais chirurgicaux cardiothoraciques (CTSN), from 2013-07-17 to 2019-01-31
Data provided by the Université Laval research projects registery