Dr. Richard Larivière is a professor in the Department of Medicine at Laval University, and a researcher within the Endocrinology and Nephrology axis of the CHU of Quebec Research Centre. He is also Director of Master’s and PhD programs in Clinical and Biomedical Sciences of the Faculty of Medicine at Laval University. Following his doctoral studies in Clinical Sciences (cardiovascular pharmacology) at the Université de Montréal, and postdoctoral studies in molecular endocrinology at McGill University, Dr. Larivière established himself as a professor-researcher in nephrology and hypertension at L’Hôtel-Dieu de Québec. He is an active member of the Amgen-Laval University Research Chair in Nephrology, a multidisciplinary group of fundamentalist and clinical researchers.

The main objective of Dr. Larivière’s research is to better define the mechanisms of arterial hypertension and remodeling of the blood vessel wall. More specifically, he studies the role of endothelial dysfunction, that is, factors derived from the vascular endothelium in the pathogenesis of arterial hypertension, vascular and renal damage in the case of chronic renal failure, and aging. Over the years, he has demonstrated that an imbalance in endothelial production of vasoconstrictor and vasodilator factors, as well as pro-inflammatory factors, contributes significantly to the increase of arterial pressure and rigidity by stimulating, among other things, hypertrophic remodeling and calcification of the blood vessel wall. He has also demonstrated that endothelial dysfunction can be modulated by various endocrine factors and pharmacological agents, including certain drugs. Dr. Larivière’s research uses a variety of experimental models and human tissue libraries.

L'Hôtel-Dieu de Québec
10, rue McMahon
2853
Québec, Québec
Canada G1R 2J6

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Mac-Way F, Poulin A, Utescu MS, De Serres SA, Marquis K, Douville P, Desmeules S, Lariviere R, Lebel M, Agharazii M

The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study.

Journal Article

Nephrol Dial Transplant, 29 (11), pp. 2113-20, 2014, ISSN: 0931-0509.

Abstract | Links:

Mac-Way F, Couture V, Utescu MS, Ignace S, De Serres SA, Loignon RC, Marquis K, Lariviere R, Agharazii M

Advanced glycation end products, aortic stiffness, and wave reflection in peritoneal dialysis as compared to hemodialysis.

Journal Article

Int Urol Nephrol, 46 (4), pp. 817-24, 2014, ISSN: 0301-1623.

Abstract | Links:

Gauthier-Bastien A, Ung RV, Lariviere R, Mac-Way F, Lebel M, Agharazii M

Vascular remodeling and media calcification increases arterial stiffness in chronic kidney disease.

Journal Article

Clin Exp Hypertens, 36 (3), pp. 173-80, 2014, ISSN: 1064-1963.

Abstract | Links:

Utescu MS, Couture V, Mac-Way F, De Serres SA, Marquis K, Lariviere R, Desmeules S, Lebel M, Boutouyrie P, Agharazii M

Determinants of progression of aortic stiffness in hemodialysis patients: a prospective longitudinal study.

Journal Article

Hypertension, 62 (1), pp. 154-60, 2013, ISSN: 0194-911X.

Abstract | Links:

Bourgoin F, Bachelard H, Badeau M, Lariviere R, Nadeau A, Pitre M

Effects of tempol on endothelial and vascular dysfunctions and insulin resistance induced by a high-fat high-sucrose diet in the rat.

Journal Article

Can J Physiol Pharmacol, 91 (7), pp. 547-61, 2013, ISSN: 0008-4212.

Abstract | Links:

Savard S, Lavoie P, Villeneuve C, Agharazii M, Lebel M, Lariviere R

eNOS gene delivery prevents hypertension and reduces renal failure and injury in rats with reduced renal mass.

Journal Article

Nephrol Dial Transplant, 27 (6), pp. 2182-90, 2012, ISSN: 0931-0509.

Abstract | Links:

Therrien FJ, Agharazii M, Lebel M, Lariviere R

Neutralization of tumor necrosis factor-alpha reduces renal fibrosis and hypertension in rats with renal failure.

Journal Article

Am J Nephrol, 36 (2), pp. 151-61, 2012, ISSN: 0250-8095.

Abstract | Links:

Ignace S, Utescu MS, De Serres SA, Marquis K, Gaudreault-Tremblay MM, Lariviere R, Cote I, Houde I, Lebel M, Agharazii M

Age-related and blood pressure-independent reduction in aortic stiffness after kidney transplantation.

Journal Article

J Hypertens, 29 (1), pp. 130-6, 2011, ISSN: 0263-6352.

Abstract | Links:

Rancourt ME, Rodrigue ME, Agharazii M, Lariviere R, Lebel M

Role of oxidative stress in erythropoietin-induced hypertension in uremic rats.

Journal Article

Am J Hypertens, 23 (3), pp. 314-20, 2010, ISSN: 0895-7061.

Abstract | Links:

Cellier E, Midaoui AE, Robitaille GA, Richard DE, Lariviere R, Lebel M

Effects of TGF-beta1 on endothelial factors.

Journal Article

Arch Physiol Biochem, 116 (1), pp. 50-5, 2010, ISSN: 1381-3455.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Proline hydroxylase inhibitors: linking HIF-1 to arterial calcification, Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2019-07-01 to 2021-06-30
  • Rôle de la dysfonction endothéliale dans le remodelage et la calcification vasculaire en insuffisance rénale chronique, Subvention, Fondation de l'Université Laval, from 2016-04-01 to 2022-03-31
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