Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.

L'Hôtel-Dieu de Québec
9, rue McMahon
0734-3
Québec, Québec
Canada G1R 2J6

Latest news

Data not available

35 entries « 3 of 4 »

Fournier MJ, Gareau C, Mazroui R

The chemotherapeutic agent bortezomib induces the formation of stress granules.

Journal Article

Cancer Cell Int, 10 (1), pp. 12, 2010.

Abstract | Links:

Mokas S, Mills JR, Garreau C, Fournier MJ, Robert F, Arya P, Kaufman RJ, Pelletier J, Mazroui R

Uncoupling stress granule assembly and translation initiation inhibition.

Journal Article

Mol Biol Cell, 20 (11), pp. 2673-83, 2009, ISSN: 1059-1524.

Abstract | Links:

Goulet I, Boisvenue S, Mokas S, Mazroui R, Cote J

TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.

Journal Article

Hum Mol Genet, 17 (19), pp. 3055-74, 2008, ISSN: 0964-6906.

Abstract | Links:

Mazroui R, Di Marco S, Clair E, von Roretz C, Tenenbaum SA, Keene JD, Saleh M, Gallouzi IE

Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis.

Journal Article

J Cell Biol, 180 (1), pp. 113-27, 2008, ISSN: 0021-9525.

Abstract | Links:

Pelletier J, Mazroui R, Sukarieh R, Harvey I, Gallouzi IE

Stress granules in cell survival

Book Chapter

RB, Denman (Ed.): RNA Binding Proteins in Development and Disease , pp. 13-33, Trivandrum, Kerala,, Research Signpost, 2008, ISBN: 978-81-308-0221-3.

Dormoy-Raclet V, Menard I, Clair E, Kurban G, Mazroui R, Di Marco S, von Roretz C, Pause A, Gallouzi IE

The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner.

Journal Article

Mol Cell Biol, 27 (15), pp. 5365-80, 2007, ISSN: 0270-7306.

Abstract | Links:

Mazroui R, Di Marco S, Kaufman RJ, Gallouzi IE

Inhibition of the ubiquitin-proteasome system induces stress granule formation.

Journal Article

Mol Biol Cell, 18 (7), pp. 2603-18, 2007, ISSN: 1059-1524.

Abstract | Links:

Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J

Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation.

Journal Article

Mol Biol Cell, 17 (10), pp. 4212-9, 2006, ISSN: 1059-1524.

Abstract | Links:

Huot ME, Bisson N, Davidovic L, Mazroui R, Labelle Y, Moss T, Khandjian EW

The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.

Journal Article

Mol Biol Cell, 16 (9), pp. 4350-61, 2005, ISSN: 1059-1524.

Abstract | Links:

Khandjian EW, Huot ME, Tremblay S, Davidovic L, Mazroui R, Bardoni B

Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles.

Journal Article

Proc Natl Acad Sci U S A, 101 (36), pp. 13357-62, 2004, ISSN: 0027-8424.

Abstract | Links:

35 entries « 3 of 4 »
Signaler des ajouts ou des modifications

Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Defining the role of stress granules (SG) in RNA stability and translation, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2020-03-31 to 2021-03-31
  • Role of FXR proteins in the cell stress response., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery