Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.

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Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De Strooper B, Hebert SS

Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.

Journal Article

PLoS ONE, 9 (1), pp. e85510, 2014.

Abstract | Links:

Berger A, Ivanova E, Gareau C, Scherrer A, Mazroui R, Strub K

Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA.

Journal Article

Nucleic Acids Res, 42 (17), pp. 11203-17, 2014, ISSN: 0305-1048.

Abstract | Links:

Moutaoufik MT, El Fatimy R, Nassour H, Gareau C, Lang J, Tanguay RM, Mazroui R, Khandjian EW

UVC-induced stress granules in mammalian cells.

Journal Article

PLoS ONE, 9 (11), pp. e112742, 2014.

Abstract | Links:

Fournier MJ, Coudert L, Mellaoui S, Adjibade P, Gareau C, Cote MF, Sonenberg N, Gaudreault RC, Mazroui R

Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation.

Journal Article

Mol Cell Biol, 33 (11), pp. 2285-301, 2013, ISSN: 0270-7306.

Abstract | Links:

Gareau C, Martel D, Coudert L, Mellaoui S, Mazroui R

Characterization of Fragile X Mental Retardation Protein granules formation and dynamics in Drosophila.

Journal Article

Biol Open, 2 (1), pp. 68-81, 2013, ISSN: 2046-6390.

Abstract | Links:

Gareau C, Houssin E, Martel D, Coudert L, Mellaoui S, Huot ME, Laprise P, Mazroui R

Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules.

Journal Article

PLoS ONE, 8 (2), pp. e55342, 2013.

Abstract | Links:

Coudert L, Mazroui R

Les granules de stress à ARN: une question de vie ou de mort. Stress Granules: A matter of life and death

Journal Article

MSA : Médecine Sciences Amérique, 2 (2), pp. 53-71, 2013.

Di Marco S, Cammas A, Lian XJ, Kovacs EN, Ma JF, Hall DT, Mazroui R, Richardson J, Pelletier J, Gallouzi IE

The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice.

Journal Article

Nat Commun, 3 , pp. 896, 2012, ISSN: 2041-1723.

Abstract | Links:

von Roretz C, Di Marco S, Mazroui R, Gallouzi IE

Turnover of AU-rich-containing mRNAs during stress: a matter of survival.

Journal Article

Wiley Interdiscip Rev RNA, 2 (3), pp. 336-47, 2011, ISSN: 1757-7004.

Abstract | Links:

Gareau C, Fournier MJ, Filion C, Coudert L, Martel D, Labelle Y, Mazroui R

p21(WAF1/CIP1) upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis.

Journal Article

PLoS ONE, 6 (5), pp. e20254, 2011.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Defining the role of stress granules (SG) in RNA stability and translation, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2020-03-31 to 2021-03-31
  • Role of FXR proteins in the cell stress response., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery