Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.
9, rue McMahon
Canada G1R 2J6
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PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation.Journal Article
Mol Biol Cell, 30 (6), pp. 778-793, 2019, ISSN: 1059-1524.
DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.Journal Article
Sci Rep, 7 (1), pp. 13832, 2017, ISSN: 2045-2322.
The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein.Journal Article
Nutrients, 8 (9), 2016, ISSN: 2072-6643.
Analysis of the translatome in solid tumors using polyribosome profiling/RNA-Seq.Journal Article
J Biol Methods, 3 (4), pp. e59, 2016, ISSN: 2326-9901.
Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells.Journal Article
Oncotarget, 6 (41), pp. 43927-43, 2015, ISSN: 1949-2553.
Localized control of oxidized RNA.Journal Article
J Cell Sci, 128 (22), pp. 4210-9, 2015, ISSN: 0021-9533.
Control of mRNA turnover: implication of cytoplasmic RNA granules.Journal Article
Semin Cell Dev Biol, 34 , pp. 15-23, 2014, ISSN: 1084-9521.
[Role of HRI in apoptosis resistance].Journal Article
Med Sci (Paris), 30 (10), pp. 882-8, 2014, ISSN: 0767-0974.
Analysis of translation initiation during stress conditions by polysome profiling.Journal Article
J Vis Exp, (87), 2014.
Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.Journal Article
PLoS ONE, 9 (1), pp. e85510, 2014.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
- Role of FXR proteins in the cell stress response., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2022-03-31