Dr. Rachid Mazroui, a Ph.D., is a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at the Faculty of Medicine at Laval University. The researcher is studying the translational mechanisms involved in the resistance of cancer cells to therapeutic drugs. Specifically, his group aims to understand the role of RNA stress granules in the translational regulation giving rise to chemoresistance. The ultimate goal is to identify factors that can be targeted to specifically prevent the formation of stress granules in therapeutic conditions, thus sensitizing cancer cells to treatment.

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36 entries « 1 of 4 »

Shah VN, Houle F, Lavoie-Ouellet C, Mazroui R, Michaud P, Adjibade P, Quévillon Huberdeau M, Rioux R, Gu W, Simard MJ

The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.

Journal Article

PLoS Genet, 17 (4), 2021.

Abstract | Links:

Adjibade P, Simoneau B, Ledoux N, Gauthier WN, Nkurunziza M, Khandjian EW, Mazroui R

Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation.

Journal Article

PLoS One, 15 (5), 2020.

Abstract | Links:

Haghandish N, Baldwin RM, Morettin A, Dawit HT, Adhikary H, Masson JY, Mazroui R, Trinkle-Mulcahy L, Cote J

PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation.

Journal Article

Mol Biol Cell, 30 (6), 2019.

Abstract | Links:

Adjibade P, Grenier St-Sauveur V, Bergeman J, Huot ME, Khandjian EW, Mazroui R

DDX3 regulates endoplasmic reticulum stress-induced ATF4 expression.

Journal Article

Sci Rep, 7 (1), 2017.

Abstract | Links:

Adjibade P, Grenier St-Sauveur V, Droit A, Khandjian EW, Toren P, Mazroui R

Analysis of the translatome in solid tumors using polyribosome profiling/RNA-Seq.

Journal Article

J Biol Methods, 3 (4), 2016.

Abstract | Links:

Marquez-Mota CC, Rodriguez-Gaytan C, Adjibade P, Mazroui R, Galvez A, Granados O, Tovar AR, Torres N

The mTORC1-Signaling Pathway and Hepatic Polyribosome Profile Are Enhanced after the Recovery of a Protein Restricted Diet by a Combination of Soy or Black Bean with Corn Protein.

Journal Article

Nutrients, 8 (9), 2016.

Abstract | Links:

Adjibade P, St-Sauveur VG, Quevillon Huberdeau M, Fournier MJ, Savard A, Coudert L, Khandjian EW, Mazroui R

Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells.

Journal Article

Oncotarget, 6 (41), 2015.

Abstract | Links:

Zhan Y, Dhaliwal JS, Adjibade P, Uniacke J, Mazroui R, Zerges W

Localized control of oxidized RNA.

Journal Article

J Cell Sci, 128 (22), 2015.

Abstract | Links:

Coudert L, Adjibade P, Mazroui R

Analysis of translation initiation during stress conditions by polysome profiling.

Journal Article

J Vis Exp, (87), 2014.

Abstract | Links:

Joncas FH, Adjibade P, Mazroui R

[Role of HRI in apoptosis resistance].

Journal Article

Med Sci (Paris), 30 (10), 2014.

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36 entries « 1 of 4 »
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Active projects

  • Role of FXR proteins in the cell stress response., from 2015-04-01 to 2022-03-31

Recently finished projects

  • Defining the role of stress granules (SG) in RNA stability and translation, from 2020-03-31 to 2021-03-31
Data provided by the Université Laval research projects registery