Dr. Leclerc is a professor in the Department of Obstetrics, Gynecology and Reproduction of the Faculty of Medicine at Laval University. Being a regular researcher in the Reproductive, Maternal and Child Health axis at the CHU of Quebec-Laval University Research Centre, he is also a member of the Centre for Research in Reproduction, Development and Intergenerational Health of Laval University (CRDSI), and is part of the Réseau québécois en reproduction (RQR). Dr. Leclerc is involved in the training of graduate students enrolled in the Molecular Medicine and Molecular and Cellular Biology programs of the Faculty of Medicine, as well as Animal Sciences of the Faculty of Agricultural and Food Sciences. He is also a member of the Molecular Medicine Program Committee.

Dr. Leclerc’s research interests are in the field of male infertility. Following ejaculation, spermatozoa, although morphologically whole and motile, are unable to fertilize an egg. They must undergo a maturation stage that normally occurs in the female genital tract as they move to the fertilization site. The intracellular mechanisms that cause metabolic and membrane changes that make sperm capable of interacting and fertilizing the egg are at the heart of Dr. Leclerc’s research activities.

His research also focuses on the mechanisms involved in the interactions between gametes during fertilization, and more specifically on the proteins mediating the recognition and binding of spermatozoa to the egg.

About 7% of men suffer from infertility and, for nearly one-third, the reasons are unknown. Dr. Leclerc’s research may help to better understand the causes of these cases of unexplained infertility. In addition, a better understanding of the physiology and fertilization potential of sperm improves the success rate of medically assisted reproduction and cryopreservation techniques by reducing their deleterious effects.

CHUL
2705, boulevard Laurier
T3-56
Québec, Québec
Canada G1V 4G2

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47 entries « 5 of 5 »

Lessard C, Masseau I, Bilodeau JF, Kroetsch T, Twagiramungu H, Bailey JL, Leclerc P, Sullivan R

Semen characteristics of genetically identical quadruplet bulls.

Journal Article

Theriogenology, 59 (8), pp. 1865-77, 2003, ISSN: 0093-691X.

Abstract | Links:

Huot ME, Mazroui R, Leclerc P, Khandjian EW

Developmental expression of the fragile X-related 1 proteins in mouse testis: association with microtubule elements.

Journal Article

Hum Mol Genet, 10 (24), pp. 2803-11, 2001, ISSN: 0964-6906.

Abstract | Links:

Lessard C, Parent S, Leclerc P, Bailey JL, Sullivan R

Cryopreservation alters the levels of the bull sperm surface protein P25b.

Journal Article

J Androl, 21 (5), pp. 700-7, 2000, ISSN: 0196-3635.

Abstract | Links:

Leclerc P, Sirard MA, Chafouleas JG, Lambert RD

Decrease in calmodulin concentrations during heparin-induced capacitation in bovine spermatozoa.

Journal Article

J Reprod Fertil, 94 (1), pp. 23-32, 1992, ISSN: 0022-4251.

Abstract | Links:

Leclerc P, Sirard MA, Chafouleas JG, Lambert RD

Decreased binding of calmodulin to bull sperm proteins during heparin-induced capacitation.

Journal Article

Biol Reprod, 42 (3), pp. 483-9, 1990, ISSN: 0006-3363.

Abstract | Links:

Leclerc P, Langlais J, Lambert RD, Sirard MA, Chafouleas JG

Effect of heparin on the expression of calmodulin-binding proteins in bull spermatozoa.

Journal Article

J Reprod Fertil, 85 (2), pp. 615-22, 1989, ISSN: 0022-4251.

Abstract | Links:

King WA, Xu KP, Sirard MA, Greve T, Leclerc P, Lambert RD, Jacques P

Cytogenetic study of parthenogenetically activated bovine oocytes matured in vivo and in vitro.

Journal Article

Gamete Res, 20 (3), pp. 265-74, 1988, ISSN: 0148-7280.

Abstract | Links:

47 entries « 5 of 5 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-02-02
  • La protéine spermatique SPAM1 comme marqueur de la qualité de la semence, de la fertilité des taureaux, et de la vocation laitière ou bouchère du cheptel bovin québécois., Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2018-04-01 to 2021-03-31
  • Réseau Québécois en Reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31

Recently finished projects

  • Importance of the interactions between intracellular signalling pathways during sperm acquisition of fertilizing competence., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2020-03-31
Data provided by the Université Laval research projects registery