Dr. Leclerc is a professor in the Department of Obstetrics, Gynecology and Reproduction of the Faculty of Medicine at Laval University. Being a regular researcher in the Reproductive, Maternal and Child Health axis at the CHU of Quebec-Laval University Research Centre, he is also a member of the Centre for Research in Reproduction, Development and Intergenerational Health of Laval University (CRDSI), and is part of the Réseau québécois en reproduction (RQR). Dr. Leclerc is involved in the training of graduate students enrolled in the Molecular Medicine and Molecular and Cellular Biology programs of the Faculty of Medicine, as well as Animal Sciences of the Faculty of Agricultural and Food Sciences. He is also a member of the Molecular Medicine Program Committee.
Dr. Leclerc’s research interests are in the field of male infertility. Following ejaculation, spermatozoa, although morphologically whole and motile, are unable to fertilize an egg. They must undergo a maturation stage that normally occurs in the female genital tract as they move to the fertilization site. The intracellular mechanisms that cause metabolic and membrane changes that make sperm capable of interacting and fertilizing the egg are at the heart of Dr. Leclerc’s research activities.
His research also focuses on the mechanisms involved in the interactions between gametes during fertilization, and more specifically on the proteins mediating the recognition and binding of spermatozoa to the egg.
About 7% of men suffer from infertility and, for nearly one-third, the reasons are unknown. Dr. Leclerc’s research may help to better understand the causes of these cases of unexplained infertility. In addition, a better understanding of the physiology and fertilization potential of sperm improves the success rate of medically assisted reproduction and cryopreservation techniques by reducing their deleterious effects.
2705, boulevard Laurier
Canada G1V 4G2
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- Bolduc, ÈveInterneve.email@example.com
- Lavoie-Ouellet, CamilleMaster studentCHUL+1 418-525-4444, extension firstname.lastname@example.org@crchudequebec.ulaval.ca
2705, boul. Laurier
Canada G1V 4G2
- Saindon, Andrée-AnneEmployeeCHUL+1 418-525-4444, extension email@example.comAndree-Anne.Saindon@crchudequebec.ulaval.ca
2705, boulevard Laurier
Canada G1V 4G2
SPAM1 isoforms from two tissue origins are differentially localized within ejaculated bull sperm membranes and have different roles during fertilization.Journal Article
Biol Reprod, 82 (2), pp. 271-81, 2010, ISSN: 0006-3363.
Localization of Hsp60 and Grp78 in the human testis, epididymis and mature spermatozoa.Journal Article
Int J Androl, 33 (1), pp. 33-44, 2010, ISSN: 0105-6263.
Estrogen sulfotransferase is highly expressed along the bovine epididymis and is secreted into the intraluminal environment.Journal Article
J Androl, 30 (5), pp. 580-9, 2009, ISSN: 0196-3635.
Cryopreservation affects bovine sperm intracellular parameters associated with capacitation and acrosome exocytosis.Journal Article
Reprod Fertil Dev, 21 (4), pp. 525-37, 2009, ISSN: 1031-3613.
Modulation of bovine sperm signalling pathways: correlation between intracellular parameters and sperm capacitation and acrosome exocytosis.Journal Article
Reprod Fertil Dev, 21 (4), pp. 511-24, 2009, ISSN: 1031-3613.
Increased activity of the human sperm tyrosine kinase SRC by the cAMP-dependent pathway in the presence of calcium.Journal Article
Biol Reprod, 79 (4), pp. 657-66, 2008, ISSN: 0006-3363.
Expression of hck-tr, a truncated form of the src-related tyrosine kinase hck, in bovine spermatozoa and testis.Journal Article
Mol Reprod Dev, 75 (5), pp. 828-37, 2008, ISSN: 1040-452X.
Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility.Journal Article
Fertil Steril, 88 (4 Suppl), pp. 1240-7, 2007, ISSN: 0015-0282.
Expression of Hsp60 and Grp78 in the human endometrium and oviduct, and their effect on sperm functions.Journal Article
Hum Reprod, 22 (10), pp. 2606-14, 2007, ISSN: 0268-1161.
Identification and localisation of SERCA 2 isoforms in mammalian sperm.Journal Article
Mol Hum Reprod, 13 (5), pp. 307-16, 2007, ISSN: 1360-9947.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-02-02
- La protéine spermatique SPAM1 comme marqueur de la qualité de la semence, de la fertilité des taureaux, et de la vocation laitière ou bouchère du cheptel bovin québécois., Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2018-04-01 to 2021-03-31
- Réseau Québécois en Reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31
Recently finished projects
- Importance of the interactions between intracellular signalling pathways during sperm acquisition of fertilizing competence., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2020-03-31