Dr. Leclerc is a professor in the Department of Obstetrics, Gynecology and Reproduction of the Faculty of Medicine at Laval University. Being a regular researcher in the Reproductive, Maternal and Child Health axis at the CHU of Quebec-Laval University Research Centre, he is also a member of the Centre for Research in Reproduction, Development and Intergenerational Health of Laval University (CRDSI), and is part of the Réseau québécois en reproduction (RQR). Dr. Leclerc is involved in the training of graduate students enrolled in the Molecular Medicine and Molecular and Cellular Biology programs of the Faculty of Medicine, as well as Animal Sciences of the Faculty of Agricultural and Food Sciences. He is also a member of the Molecular Medicine Program Committee.
Dr. Leclerc’s research interests are in the field of male infertility. Following ejaculation, spermatozoa, although morphologically whole and motile, are unable to fertilize an egg. They must undergo a maturation stage that normally occurs in the female genital tract as they move to the fertilization site. The intracellular mechanisms that cause metabolic and membrane changes that make sperm capable of interacting and fertilizing the egg are at the heart of Dr. Leclerc’s research activities.
His research also focuses on the mechanisms involved in the interactions between gametes during fertilization, and more specifically on the proteins mediating the recognition and binding of spermatozoa to the egg.
About 7% of men suffer from infertility and, for nearly one-third, the reasons are unknown. Dr. Leclerc’s research may help to better understand the causes of these cases of unexplained infertility. In addition, a better understanding of the physiology and fertilization potential of sperm improves the success rate of medically assisted reproduction and cryopreservation techniques by reducing their deleterious effects.
2705, boulevard Laurier
Canada G1V 4G2
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- Lavoie-Ouellet, CamilleMaster studentCHUL+1 418-525-4444, extension email@example.com@crchudequebec.ulaval.ca
2705, boul. Laurier
Canada G1V 4G2
- Saindon, Andrée-AnneEmployeeCHUL+1 418-525-4444, extension firstname.lastname@example.orgAndree-Anne.Saindon@crchudequebec.ulaval.ca
2705, boulevard Laurier
Canada G1V 4G2
Implication of the human Binder of SPerm Homolog 1 (BSPH1) protein in capacitation.Journal Article
Mol Hum Reprod, 20 (5), pp. 409-21, 2014, ISSN: 1360-9947.
Stattic V, a STAT3 inhibitor, affects human spermatozoa through regulation of mitochondrial activity.Journal Article
J Cell Physiol, 228 (4), pp. 704-13, 2013, ISSN: 0021-9541.
Epididymosomes transfer epididymal sperm binding protein 1 (ELSPBP1) to dead spermatozoa during epididymal transit in bovine.Journal Article
Biol Reprod, 87 (4), pp. 94, 2012, ISSN: 0006-3363.
In memoriam: Claude Gagnon, Ph.D., 1950-2012.Journal Article
Biol Reprod, 87 (2), pp. 50, 2012, ISSN: 0006-3363.
Binder of sperm 1 and epididymal sperm binding protein 1 are associated with different bull sperm subpopulations.Journal Article
Reproduction, 143 (6), pp. 759-71, 2012, ISSN: 1470-1626.
Leukemia inhibitory factor regulates differentiation of trophoblastlike BeWo cells through the activation of JAK/STAT and MAPK3/1 MAP kinase-signaling pathways.Journal Article
Biol Reprod, 86 (2), pp. 54, 2012, ISSN: 0006-3363.
Mediators of the Jak/STAT signaling pathway in human spermatozoa.Journal Article
Biol Reprod, 85 (6), pp. 1222-31, 2011, ISSN: 0006-3363.
Infertility in a beef bull due to a failure in the capacitation process.Journal Article
Theriogenology, 76 (5), pp. 891-9, 2011, ISSN: 0093-691X.
Developmental expression of SRC-related tyrosine kinases in the mouse testis.Journal Article
J Androl, 32 (1), pp. 95-110, 2011, ISSN: 0196-3635.
Proteomic comparison of detergent-extracted sperm proteins from bulls with different fertility indexes.Journal Article
Reproduction, 139 (3), pp. 545-56, 2010, ISSN: 1470-1626.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-02-02
- La protéine spermatique SPAM1 comme marqueur de la qualité de la semence, de la fertilité des taureaux, et de la vocation laitière ou bouchère du cheptel bovin québécois., Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2018-04-01 to 2021-03-31
- Réseau Québécois en Reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31
Recently finished projects
- Importance of the interactions between intracellular signalling pathways during sperm acquisition of fertilizing competence., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2020-03-31