Dr. Leclerc is a professor in the Department of Obstetrics, Gynecology and Reproduction of the Faculty of Medicine at Laval University. Being a regular researcher in the Reproductive, Maternal and Child Health axis at the CHU of Quebec-Laval University Research Centre, he is also a member of the Centre for Research in Reproduction, Development and Intergenerational Health of Laval University (CRDSI), and is part of the Réseau québécois en reproduction (RQR). Dr. Leclerc is involved in the training of graduate students enrolled in the Molecular Medicine and Molecular and Cellular Biology programs of the Faculty of Medicine, as well as Animal Sciences of the Faculty of Agricultural and Food Sciences. He is also a member of the Molecular Medicine Program Committee.
Dr. Leclerc’s research interests are in the field of male infertility. Following ejaculation, spermatozoa, although morphologically whole and motile, are unable to fertilize an egg. They must undergo a maturation stage that normally occurs in the female genital tract as they move to the fertilization site. The intracellular mechanisms that cause metabolic and membrane changes that make sperm capable of interacting and fertilizing the egg are at the heart of Dr. Leclerc’s research activities.
His research also focuses on the mechanisms involved in the interactions between gametes during fertilization, and more specifically on the proteins mediating the recognition and binding of spermatozoa to the egg.
About 7% of men suffer from infertility and, for nearly one-third, the reasons are unknown. Dr. Leclerc’s research may help to better understand the causes of these cases of unexplained infertility. In addition, a better understanding of the physiology and fertilization potential of sperm improves the success rate of medically assisted reproduction and cryopreservation techniques by reducing their deleterious effects.
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Cholesterol-loaded cyclodextrin improves ram sperm cryoresistance in skim milk-extender.Journal Article
Anim Reprod Sci, 177 , pp. 1-11, 2017, ISSN: 0378-4320.
Papaverine-sensitive phosphodiesterase activity is measured in bovine spermatozoa.Journal Article
Andrology, 5 (1), pp. 169-179, 2017, ISSN: 2047-2919.
Novel technical strategies to optimize cryopreservation of goat semen using cholesterol-loaded cyclodextrin.Journal Article
Cryobiology, 74 , pp. 19-24, 2017, ISSN: 0011-2240.
Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa.Journal Article
Biochim Biophys Acta, 1861 (2), pp. 147-156, 2017, ISSN: 0006-3002.
Recombinant human oviductin regulates protein tyrosine phosphorylation and acrosome reaction.Journal Article
Reproduction, 152 (5), pp. 561-573, 2016, ISSN: 1470-1626.
- Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-04-30
- Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Importance of the interactions between intracellular signalling pathways during sperm acquisition of fertilizing competence., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2020-03-31
- Réseau Québécois en Reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques, from 2017-04-01 to 2023-03-31
- Spermatozoa as a model to investigate the non-genomic effects of STAT3 in cancer cell proliferation, Subvention, Fondation de l'Université Laval, from 2017-10-01 to 2018-09-30
Recently finished projects
- Importance du facteur de transcription STAT3 dans le contrôle du pouvoir fécondant des spermatozoïdes., Subvention, Fondation du CHU de Québec, from 2016-04-01 to 2017-03-31
- Importance of intracellular signaling in the regulation of sperm fertilizing competence, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2012-04-01 to 2017-03-31
- Optimization of semen processingfor the bovine artificial insemination, Partenariat, Conseil de recherches en sciences naturelles et génie Canada, Subventions de recherche et développement coopérative (RDC), from 2013-03-31 to 2016-04-30
- Regulation of cyclic nucleotide hydrolysis in bovine sperm, Partenariat, Conseil de recherches en sciences naturelles et génie Canada, Subventions de recherche et développement coopérative (RDC), from 2012-10-01 to 2016-11-14
- Réseau Québécois en reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques, from 2011-04-01 to 2017-03-31