Dr. Pierre Julien is a professor of Medicine at Laval University and the Director of the Endocrinology and Nephrology Research Unit at the Centre de recherche de CHU de Québec-Laval University. He is the Director of the Centre de recherche en endocrinologie, métabolisme et inflammation (CREMI) at Laval University, as well as the President of the Québec Society of Lipidology, Nutrition and Metabolism.

His expertise mainly focusses on the role of fatty acids, particularly omega-3 and trans fatty acids on oxidative stress in various pathologies. Thus, he is involved in the establishment of research pregnancy cohorts, such as INTAPP (International Trial of Antioxidants in the Prevention of Preeclampsia) and IRNPQEO (Integrated Research Network in Perinatology of Quebec and Eastern Ontario) cohorts to study the role of oxidative stress. Including studies on the role of antioxidants such as vitamins E et C, Dr. Julien is also involved in the demonstration of the role of oxidized fatty acids (isoprostanes) as early biomarkers of oxidative stress.

Recently, we have studied the oxidation of long-chain fatty acids by free radicals using novel analytical methods with gas chromatography and high-pressure liquid chromatography combined with mass spectrometry. We have discovered that oxidized fatty acids (isoprostanes), particularly those derived from arachidonic fatty acid (oméga-6), may be used as biomarkers for the early detection of pregnancy hypertension, but also reveal other inflammatory pathologies, such as cancer and diabetes. The actual research program is thus geared at studying the beneficial effects of anti-inflammatory omega-3 fatty acid metabolites compared to metabolites generated by pro-inflammatory omega-6 fatty acids.

We have demonstrated that metabolic and transcriptomic factors may significantly influence the response to dietary supplementation in fatty acids, suggesting inter-individual variations with important pathophysiologic effects. These results shed light on the importance of proposing personalized dietary recommendations, particularly related to the levels of omega-3 and omega-6 fatty acids.

CHUL
2705, boulevard Laurier
T-4-07
Québec, Québec
Canada G1V 4G2

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134 entries « 1 of 27 »

Guertin MH, Robitaille K, Pelletier JF, Duchesne T, Julien P, Savard J, Bairati I, Fradet V

Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial.

Journal Article

BMC Cancer, 18 (1), pp. 64, 2018.

Abstract | Links:

Du Q, Luo ZC, Nuyt AM, Audibert F, Julien P, Wei SQ, Zhang DL, Fraser W, Levy E

Vitamin A and E Nutritional Status in Relation to Leptin, Adiponectin, IGF-I and IGF-II in Early Life - a Birth Cohort Study.

Journal Article

Sci Rep, 8 (1), pp. 100, 2018, ISSN: 2045-2322.

Abstract | Links:

Da Silva MS, Bilodeau JF, Julien P, Rudkowska I

Dietary fats and F2-isoprostanes: A review of the clinical evidence.

Journal Article

Crit Rev Food Sci Nutr, 57 (18), pp. 3929-3941, 2017, ISSN: 1040-8398.

Abstract | Links:

Da Silva MS, Bilodeau JF, Larose J, Greffard K, Julien P, Barbier O, Rudkowska I

Modulation of the biomarkers of inflammation and oxidative stress by ruminant trans fatty acids and dairy proteins in vascular endothelial cells (HUVEC).

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 126 , pp. 64-71, 2017, ISSN: 0952-3278.

Abstract | Links:

Brien M, Larose J, Greffard K, Julien P, Bilodeau JF

Increased placental phospholipase A2 gene expression and free F2-isoprostane levels in response to oxidative stress in preeclampsia.

Journal Article

Placenta, 55 , pp. 54-62, 2017, ISSN: 0143-4004.

Abstract | Links:

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Active projects

  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions., Subvention, Société de recherche sur le cancer, Compétition GRePEC (SRC/FRSQ/MDEIE), from 2012-10-01 to 2019-08-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
  • Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized controlled trial (MOBYDIck trial)., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-06-30

Recently finished projects

  • Development of a non-invasive inflammatory profiling test for prostate cancer., Subvention, Cancer de la prostate Canada, Subventions d'équipe Movember (Movember Discovery Grants), from 2013-07-01 to 2016-06-30
  • Nutrigenomic approach to investigate the benefits of dairy product consumption on glucose homeostasis, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2017-06-30
  • Phase II double-blind randomised controlled trial of concentrated omega-3 (mainly EPA) before prostatectomy evaluating the effects on prostate cancer proliferation, inflammation and quality of life., Subvention, L'Institut de recherche de la Société canadienne du cancer, Subventions pour l'innovation, from 2014-02-01 to 2018-01-31
Data provided by the Université Laval research projects registery