Dr. Pierre Julien is a professor of Medicine at Laval University and the Director of the Endocrinology and Nephrology Research Unit at the Centre de recherche de CHU de Québec-Laval University. He is the Director of the Centre de recherche en endocrinologie, métabolisme et inflammation (CREMI) at Laval University, as well as the President of the Québec Society of Lipidology, Nutrition and Metabolism.

His expertise mainly focusses on the role of fatty acids, particularly omega-3 and trans fatty acids on oxidative stress in various pathologies. Thus, he is involved in the establishment of research pregnancy cohorts, such as INTAPP (International Trial of Antioxidants in the Prevention of Preeclampsia) and IRNPQEO (Integrated Research Network in Perinatology of Quebec and Eastern Ontario) cohorts to study the role of oxidative stress. Including studies on the role of antioxidants such as vitamins E et C, Dr. Julien is also involved in the demonstration of the role of oxidized fatty acids (isoprostanes) as early biomarkers of oxidative stress.

Recently, we have studied the oxidation of long-chain fatty acids by free radicals using novel analytical methods with gas chromatography and high-pressure liquid chromatography combined with mass spectrometry. We have discovered that oxidized fatty acids (isoprostanes), particularly those derived from arachidonic fatty acid (oméga-6), may be used as biomarkers for the early detection of pregnancy hypertension, but also reveal other inflammatory pathologies, such as cancer and diabetes. The actual research program is thus geared at studying the beneficial effects of anti-inflammatory omega-3 fatty acid metabolites compared to metabolites generated by pro-inflammatory omega-6 fatty acids.

We have demonstrated that metabolic and transcriptomic factors may significantly influence the response to dietary supplementation in fatty acids, suggesting inter-individual variations with important pathophysiologic effects. These results shed light on the importance of proposing personalized dietary recommendations, particularly related to the levels of omega-3 and omega-6 fatty acids.

CHUL
2705, boulevard Laurier
T4-07
Québec, Québec
Canada G1V 4G2
157 entries « 1 of 16 »

Huang R, Dong Y, Levy E, Julien P, Marc I, He H, Xu YJ, Wei SQ, Fraser WD, Luo ZC

Large-for-gestational-age, leptin and adiponectin in infancy.

Journal Article

J Clin Endocrinol Metab, 2021.

Abstract | Links:

Bilodeau JF, Gagné A, Greffard K, Audibert F, Fraser WD, Julien P

The plasma antioxidant vitamin status of the INTAPP cohort examined: The unsuspected importance of β-carotene and γ-tocopherol in preeclampsia.

Journal Article

Pregnancy Hypertens, 25 , 2021.

Abstract | Links:

Fang F, Nuyt AM, Garofalo C, Zhang J, Julien P, Fraser W, Levy E, Luo ZC

Oxidized LDL, insulin sensitivity and beta-cell function in newborns.

Journal Article

BMJ Open Diabetes Res Care, 9 (1), 2021.

Abstract | Links:

Gevariya N, Lachance G, Robitaille K, Joly Beauparlant C, Beaudoin L, Fournier E, Fradet Y, Droit A, Julien P, Marette A, Bergeron A, Fradet V

Omega-3 Eicosapentaenoic Acid Reduces Prostate Tumor Vascularity.

Journal Article

Mol Cancer Res, 19 (3), 2021.

Abstract | Links:

Khorraminezhad L, Leclercq M, O'Connor S, Julien P, Weisnagel SJ, Gagnon C, Droit A, Rudkowska I

Dairy product intake modifies gut microbiota composition among hyperinsulinemic individuals.

Journal Article

Eur J Nutr, 60 (1), 2021.

Abstract | Links:

Bilodeau JF, Gevariya N, Larose J, Robitaille K, Roy J, Oger C, Galano JM, Bergeron A, Durand T, Fradet Y, Julien P, Fradet V

Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth.

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 164 , 2021.

Abstract | Links:

Simard M, Rioux G, Morin S, Martin C, Guérin SL, Flamand N, Julien P, Fradette J, Pouliot R

Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells.

Journal Article

J Invest Dermatol, 141 (10), 2021.

Abstract | Links:

He H, Zhu WT, Nuyt AM, Marc I, Julien P, Huang R, Dubois L, Wei SQ, Zhang J, Levy E, Fraser WD, Luo ZC

Cord Blood IGF-I, Proinsulin, Leptin, HMW Adiponectin, and Ghrelin in Short or Skinny Small-for-Gestational-Age Infants.

Journal Article

J Clin Endocrinol Metab, 106 (8), 2021.

Abstract | Links:

Wei SQ, Bilodeau JF, Julien P, Luo ZC, Abenhaim HA, Bi WG, Nuyt AM, Leduc L, Audibert F, Fraser WD

Maternal vitamin D, oxidative stress, and pre-eclampsia.

Journal Article

Int J Gynaecol Obstet, 154 (3), 2021.

Abstract | Links:

Huang R, Dong Y, Nuyt AM, Levy E, Wei SQ, Julien P, Fraser WD, Luo ZC

Large birth size, infancy growth pattern, insulin resistance and β-cell function.

Journal Article

Eur J Endocrinol, 185 (1), 2021.

Abstract | Links:

157 entries « 1 of 16 »
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Active projects

  • Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions., Subvention, Société de recherche sur le cancer, Compétition GRePEC (SRC/FRSQ/MDEIE), from 2012-10-01 to 2021-12-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31

Recently finished projects

  • Confocal microscopy platform for longitudinal imaging of pathological changes in ALS mouse models, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2018-12-14 to 2019-04-30
  • Les maladies cardiométaboliques à l'ère de la révolution numérique, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-01-01 to 2020-12-31
  • Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized controlled trial (MOBYDIck trial)., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2021-07-31
  • Rencontre scientifique internationale conjointe SQLNM / CMDO 2019, Subvention, Instituts de recherche en santé du Canada, Activités de dissémination, from 2018-12-01 to 2019-11-30
Data provided by the Université Laval research projects registery