Dr. Pierre Julien is a professor of Medicine at Laval University and the Director of the Endocrinology and Nephrology Research Unit at the Centre de recherche de CHU de Québec-Laval University. He is the Director of the Centre de recherche en endocrinologie, métabolisme et inflammation (CREMI) at Laval University, as well as the President of the Québec Society of Lipidology, Nutrition and Metabolism.
His expertise mainly focusses on the role of fatty acids, particularly omega-3 and trans fatty acids on oxidative stress in various pathologies. Thus, he is involved in the establishment of research pregnancy cohorts, such as INTAPP (International Trial of Antioxidants in the Prevention of Preeclampsia) and IRNPQEO (Integrated Research Network in Perinatology of Quebec and Eastern Ontario) cohorts to study the role of oxidative stress. Including studies on the role of antioxidants such as vitamins E et C, Dr. Julien is also involved in the demonstration of the role of oxidized fatty acids (isoprostanes) as early biomarkers of oxidative stress.
Recently, we have studied the oxidation of long-chain fatty acids by free radicals using novel analytical methods with gas chromatography and high-pressure liquid chromatography combined with mass spectrometry. We have discovered that oxidized fatty acids (isoprostanes), particularly those derived from arachidonic fatty acid (oméga-6), may be used as biomarkers for the early detection of pregnancy hypertension, but also reveal other inflammatory pathologies, such as cancer and diabetes. The actual research program is thus geared at studying the beneficial effects of anti-inflammatory omega-3 fatty acid metabolites compared to metabolites generated by pro-inflammatory omega-6 fatty acids.
We have demonstrated that metabolic and transcriptomic factors may significantly influence the response to dietary supplementation in fatty acids, suggesting inter-individual variations with important pathophysiologic effects. These results shed light on the importance of proposing personalized dietary recommendations, particularly related to the levels of omega-3 and omega-6 fatty acids.
2705, boulevard Laurier
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Drinkable lecithin nanovesicles to study the biological effects of individual hydrophobic macronutrients and food preferences.Journal Article
Food Chem, 322 , pp. 126736, 2020, ISSN: 0308-8146.
Dairy product intake modifies gut microbiota composition among hyperinsulinemic individuals.Journal Article
Eur J Nutr, 2020, ISSN: 1436-6207.
Modulation of the Lipid Profile of Reconstructed Skin Substitutes after Essential Fatty Acid Supplementation Affects Testosterone Permeability.Journal Article
Cells, 8 (10), 2019, ISSN: 2073-4409.
Impact of a High Intake of Dairy Product on Insulin Sensitivity in Hyperinsulinemic Adults: A Crossover Randomized Controlled Trial.Journal Article
Curr Dev Nutr, 3 (8), pp. nzz083, 2019, ISSN: 2475-2991.
Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level.Journal Article
Nutrients, 11 (7), 2019, ISSN: 2072-6643.
Omega-3 fatty acids decrease prostate cancer progression associated with an anti-tumor immune response in eugonadal and castrated mice.Journal Article
Prostate, 79 (1), pp. 9-20, 2019, ISSN: 0270-4137.
Increased Dairy Product Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes.Journal Article
Mol Nutr Food Res, 63 (19), pp. e1900126, 2019, ISSN: 1613-4125.
Large-for-Gestational-Age May Be Associated With Lower Fetal Insulin Sensitivity and β-Cell Function Linked to Leptin.Journal Article
J Clin Endocrinol Metab, 103 (10), pp. 3837-3844, 2018, ISSN: 0021-972X.
Association of pre-eclampsia with SOD2 Ala16Val polymorphism among mother-father-infant triads.Journal Article
Int J Gynaecol Obstet, 142 (2), pp. 221-227, 2018, ISSN: 0020-7292.
Effects of concentrated long-chain omega-3 polyunsaturated fatty acid supplementation before radical prostatectomy on prostate cancer proliferation, inflammation, and quality of life: study protocol for a phase IIb, randomized, double-blind, placebo-controlled trial.Journal Article
BMC Cancer, 18 (1), pp. 64, 2018.
- Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions., Subvention, Société de recherche sur le cancer, Compétition GRePEC (SRC/FRSQ/MDEIE), from 2012-10-01 to 2020-08-31
- Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
- Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized controlled trial (MOBYDIck trial)., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2021-03-31
Recently finished projects
- Confocal microscopy platform for longitudinal imaging of pathological changes in ALS mouse models, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2018-12-14 to 2019-04-30
- Rencontre scientifique internationale conjointe SQLNM / CMDO 2019, Subvention, Instituts de recherche en santé du Canada, Activités de dissémination, from 2018-12-01 to 2019-11-30