Dr. Pierre Julien is a professor of Medicine at Laval University and the Director of the Endocrinology and Nephrology Research Unit at the Centre de recherche de CHU de Québec-Laval University. He is the Director of the Centre de recherche en endocrinologie, métabolisme et inflammation (CREMI) at Laval University, as well as the President of the Québec Society of Lipidology, Nutrition and Metabolism.

His expertise mainly focusses on the role of fatty acids, particularly omega-3 and trans fatty acids on oxidative stress in various pathologies. Thus, he is involved in the establishment of research pregnancy cohorts, such as INTAPP (International Trial of Antioxidants in the Prevention of Preeclampsia) and IRNPQEO (Integrated Research Network in Perinatology of Quebec and Eastern Ontario) cohorts to study the role of oxidative stress. Including studies on the role of antioxidants such as vitamins E et C, Dr. Julien is also involved in the demonstration of the role of oxidized fatty acids (isoprostanes) as early biomarkers of oxidative stress.

Recently, we have studied the oxidation of long-chain fatty acids by free radicals using novel analytical methods with gas chromatography and high-pressure liquid chromatography combined with mass spectrometry. We have discovered that oxidized fatty acids (isoprostanes), particularly those derived from arachidonic fatty acid (oméga-6), may be used as biomarkers for the early detection of pregnancy hypertension, but also reveal other inflammatory pathologies, such as cancer and diabetes. The actual research program is thus geared at studying the beneficial effects of anti-inflammatory omega-3 fatty acid metabolites compared to metabolites generated by pro-inflammatory omega-6 fatty acids.

We have demonstrated that metabolic and transcriptomic factors may significantly influence the response to dietary supplementation in fatty acids, suggesting inter-individual variations with important pathophysiologic effects. These results shed light on the importance of proposing personalized dietary recommendations, particularly related to the levels of omega-3 and omega-6 fatty acids.

CHUL
2705, boulevard Laurier
T-4-07
Québec, Québec
Canada G1V 4G2

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140 entries « 1 of 28 »

Gevariya N, Besancon M, Robitaille K, Picard V, Diabate L, Alesawi A, Julien P, Fradet Y, Bergeron A, Fradet V

Omega-3 fatty acids decrease prostate cancer progression associated with an anti-tumor immune response in eugonadal and castrated mice.

Journal Article

Prostate, 2018, ISSN: 0270-4137.

Abstract | Links:

Luo ZC, Julien P, Wei SQ, Audibert F, Fraser WD, Maternal, Infant Research on Oxidative Stress (MIROS) study group

Association of pre-eclampsia with SOD2 Ala16Val polymorphism among mother-father-infant triads.

Journal Article

Int J Gynaecol Obstet, 142 (2), pp. 221-227, 2018, ISSN: 0020-7292.

Abstract | Links:

Taschereau-Charron A, Bilodeau JF, Larose J, Greffard K, Berthiaume L, Audibert F, Fraser WD, Julien P, Rudkowska I

F2-isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes.

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 135 , pp. 115-120, 2018, ISSN: 0952-3278.

Abstract | Links:

Dong Y, Luo ZC, Nuyt AM, Audibert F, Wei SQ, Abenhaim HA, Bujold E, Julien P, Huang H, Levy E, Fraser WD, 3D cohort study group

Large-for-Gestational-Age May be Associated with Lower Fetal Insulin Sensitivity and β-Cell Function Linked to Leptin.

Journal Article

J Clin Endocrinol Metab, 2018, ISSN: 0021-972X.

Abstract | Links:

Zhang DL, Du Q, Djemli A, Julien P, Fraser WD, Luo ZC

Cord blood insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin, and their associations with insulin sensitivity, β-cell function and adiposity in infancy.

Journal Article

Diabet Med, 2018, ISSN: 0742-3071.

Abstract | Links:

140 entries « 1 of 28 »

Active projects

  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions., Subvention, Société de recherche sur le cancer, Compétition GRePEC (SRC/FRSQ/MDEIE), from 2012-10-01 to 2019-08-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
  • Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized controlled trial (MOBYDIck trial)., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-06-30

Recently finished projects

  • Development of a non-invasive inflammatory profiling test for prostate cancer., Subvention, Cancer de la prostate Canada, Subventions d'équipe Movember (Movember Discovery Grants), from 2013-07-01 to 2016-06-30
  • Nutrigenomic approach to investigate the benefits of dairy product consumption on glucose homeostasis, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2017-06-30
  • Phase II double-blind randomised controlled trial of concentrated omega-3 (mainly EPA) before prostatectomy evaluating the effects on prostate cancer proliferation, inflammation and quality of life., Subvention, L'Institut de recherche de la Société canadienne du cancer, Subventions pour l'innovation, from 2014-02-01 to 2018-01-31
Data provided by the Université Laval research projects registery