Dr. Paul Isenring has been a Professor of Medicine in the Department of Medicine at Laval University since 2011. He holds a doctorate in medicine, which he obtained in 1986 from Laval University, as well as certificates in internal medicine and nephrology, obtained in 1989 and 1991 from the Collège des médecins du Québec and the Royal College of Physicians and Surgeons of Canada. Upon completing his training in Nephrology, he began graduate studies at Yale University, where he obtained a PhD in molecular physiology in early 1996. He then pursued postdoctoral studies for three years at the same institution before establishing himself as an independent researcher at L’Hôtel-Dieu de Québec’s Research Centre.
Since returning to Quebec, Dr. Isenring has devoted 70% of his time to research, working mainly in the field of applied membrane transport. He is particularly interested in a family of membrane proteins called cation-chloride cotransporters, whose role is to allow the passage of chloride with that of sodium and/or potassium across the cell surface. He is more specifically interested in the molecular determinants that underlie the function, assembly and regulation of these proteins, as well as their roles in the renal tubular epithelium and the cardiovascular system. To achieve his goals, he made use of different heterologous expression systems and animal models, while using directed mutagenesis.
Dr. Isenring has three other fields of interest. He is working to discover new transport systems by characterizing the function of candidate proteins whose role is either unknown or more complex than demonstrated in previous studies. He is also involved in the investigation of various human genetic diseases through the identification of associated mutations as well as in vitro characterization of genetic defects. Finally, Dr. Isenring devotes a part of his time to the care of patients who are suffering from electrolyte disorders and nephrological problems, while also teaching externs and residents of medicine.
The work of Dr. Isenring and his team has led to several discoveries such as the identification of (1) several mechanisms that allow cation-chloride cotransporters to perform both their operational and physiological roles, and to be regulated at the plasma membrane, (2) new functions for different membrane proteins , including that of silicon transport by aquaporins, and (3) unprecedented nosological entities or pathogenic mechanisms hitherto unknown.
10, rue McMahon
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10, rue McMahon
Canada G1R 2J6
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10, rue McMahon
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Molecular characteristics and physiological roles of Na+ -K+ -Cl- cotransporter 2.Journal Article
J Cell Physiol, 236 (3), pp. 1712-1729, 2021, ISSN: 0021-9541.
Somatic non-cancerous PIK3CA-related overgrowth syndrome treated with alpelisib in North America.Journal Article
J Mol Med, 99 (3), pp. 311-313, 2021, ISSN: 0946-2716.
The grapevine NIP2;1 aquaporin is a silicon channel.Journal Article
J Exp Bot, 71 (21), pp. 6789-6798, 2020, ISSN: 0022-0957.
Correction: Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology.Journal Article
Mol Psychiatry, 2020, ISSN: 1359-4184.
Si permeability of a deficient Lsi1 aquaporin in tobacco can be enhanced through a conserved residue substitution.Journal Article
Plant Direct, 3 (8), pp. e00163, 2019, ISSN: 2475-4455.
K+-Cl- cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells.Journal Article
J Hematol Oncol, 12 (1), pp. 74, 2019.
Regulation of Na+-K+-Cl- cotransporter type 2 by the with no lysine kinase-dependent signaling pathway.Journal Article
Am J Physiol Cell Physiol, 317 (1), pp. C20-C30, 2019, ISSN: 0363-6143.
Physiological roles and molecular mechanisms of K+ -Cl- cotransport in the mammalian kidney and cardiovascular system: where are we?Journal Article
J Physiol, 597 (6), pp. 1451-1465, 2019, ISSN: 0022-3751.
A "double hit" model of cystic kidney disease.Journal Article
Kidney Int, 95 (5), pp. 1275, 2019, ISSN: 0085-2538.
Endocytic recycling of Na+ -K+ -Cl- cotransporter type 2: importance of exon 4.Journal Article
J Physiol, 597 (16), pp. 4263-4276, 2019, ISSN: 0022-3751.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Nouveau paradigme du transport de silicium chez les plantes dans un contexte d’une agriculture durable, Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2020-04-01 to 2023-03-31
Recently finished projects
- (FRSQ 90258) Cotransporteur K-Cl de type 3, un nouveau joueur et une cible thérapeutique prometteuse dans le maintien de l'homéostasie cardiométabolique , Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2019-01-31 to 2020-03-31
- Amélioration de la résistance aux stress hydriques et biotiques chez lesp lantes par l'absorption optimisée du silicium, Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2016-04-01 to 2021-03-31
- Les atteintes cardiovasculaires dans le syndrome d'Andermann , Subvention, Fondation du CHU de Québec, from 2019-02-14 to 2020-03-31
- Molecular characterization of the renal K-C1 dotransporters., Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2016-07-01 to 2019-06-30
- Optimising plant resilience to abiotic and biotic stresses through improved silicon absorption, Partenariat, Conseil de recherches en sciences naturelles et génie Canada, Subvention de partenariat stratégique (SPS), from 2017-09-30 to 2020-12-29
- Soutien de votre projet de recherche en néphrologie, Subvention, Fondation du CHU de Québec, from 2018-04-27 to 2019-04-26