Dr. Paul Isenring has been a Professor of Medicine in the Department of Medicine at Laval University since 2011. He holds a doctorate in medicine, which he obtained in 1986 from Laval University, as well as certificates in internal medicine and nephrology, obtained in 1989 and 1991 from the Collège des médecins du Québec and the Royal College of Physicians and Surgeons of Canada. Upon completing his training in Nephrology, he began graduate studies at Yale University, where he obtained a PhD in molecular physiology in early 1996. He then pursued postdoctoral studies for three years at the same institution before establishing himself as an independent researcher at L’Hôtel-Dieu de Québec’s Research Centre.

Since returning to Quebec, Dr. Isenring has devoted 70% of his time to research, working mainly in the field of applied membrane transport. He is particularly interested in a family of membrane proteins called cation-chloride cotransporters, whose role is to allow the passage of chloride with that of sodium and/or potassium across the cell surface. He is more specifically interested in the molecular determinants that underlie the function, assembly and regulation of these proteins, as well as their roles in the renal tubular epithelium and the cardiovascular system. To achieve his goals, he made use of different heterologous expression systems and animal models, while using directed mutagenesis.

Dr. Isenring has three other fields of interest. He is working to discover new transport systems by characterizing the function of candidate proteins whose role is either unknown or more complex than demonstrated in previous studies. He is also involved in the investigation of various human genetic diseases through the identification of associated mutations as well as in vitro characterization of genetic defects. Finally, Dr. Isenring devotes a part of his time to the care of patients who are suffering from electrolyte disorders and nephrological problems, while also teaching externs and residents of medicine.

The work of Dr. Isenring and his team has led to several discoveries such as the identification of (1) several mechanisms that allow cation-chloride cotransporters to perform both their operational and physiological roles, and to be regulated at the plasma membrane, (2) new functions for different membrane proteins , including that of silicon transport by aquaporins, and (3) unprecedented nosological entities or pathogenic mechanisms hitherto unknown.

L'Hôtel-Dieu de Québec
10, rue McMahon
3853-1
Québec, Québec
Canada G1R 2J6

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Garneau AP, Marcoux AA, Frenette-Cotton R, Belanger R, Isenring P

A new gold standard approach to characterize the transport of Si across cell membranes in animals.

Journal Article

J Cell Physiol, 2018, ISSN: 0021-9541.

Abstract | Links:

Frenette-Cotton R, Marcoux AA, Garneau AP, Noel M, Isenring P

Phosphoregulation of K+ -Cl- cotransporters during cell swelling: Novel insights.

Journal Article

J Cell Physiol, 233 (1), pp. 396-408, 2018, ISSN: 0021-9541.

Abstract | Links:

Garneau AP, Marcoux AA, Frenette-Cotton R, Mac-Way F, Lavoie JL, Isenring P

Molecular insights into the normal operation, regulation, and multisystemic roles of K+-Cl- cotransporter 3 (KCC3).

Journal Article

Am J Physiol Cell Physiol, 313 (5), pp. C516-C532, 2017, ISSN: 0363-6143.

Abstract | Links:

Ratcliffe S, Jugdaohsingh R, Vivancos J, Marron A, Deshmukh R, Ma JF, Mitani-Ueno N, Robertson J, Wills J, Boekschoten MV, Muller M, Mawhinney RC, Kinrade SD, Isenring P, Belanger RR, Powell JJ

Identification of a mammalian silicon transporter.

Journal Article

Am J Physiol Cell Physiol, 312 (5), pp. C550-C561, 2017, ISSN: 0363-6143.

Abstract | Links:

Marcoux AA, Garneau AP, Frenette-Cotton R, Slimani S, Mac-Way F, Isenring P

Molecular features and physiological roles of K+-Cl- cotransporter 4 (KCC4).

Journal Article

Biochim Biophys Acta, 1861 (12), pp. 3154-3166, 2017, ISSN: 0006-3002.

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Active projects

  • Amélioration de la résistance aux stress hydriques et biotiques chez lesp lantes par l'absorption optimisée du silicium, Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2016-04-01 to 2020-03-31
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Optimising plant resilience to abiotic and biotic stresses through improved silicon absorption, Partenariat, Conseil de recherches en sciences naturelles et génie Canada, Subvention de partenariat stratégique (SPS), from 2017-09-30 to 2020-12-29

Recently finished projects

  • (FRQS 71717) Matériel de radiotélémétrie pour les souris, Subvention, Fondation du CHU de Québec, from 2016-01-26 to 2017-01-25
  • (FRSQ 78516) Recherche clinique en néphrologie , Subvention, Fondation du CHU de Québec, from 2017-05-31 to 2018-05-30
  • Chaire de recherche du Canada en physiologie moléculaire, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2011-07-01 to 2016-06-30
  • Molecular characterization of the renal K-C1 dotransporters., Subvention, Fondation canadienne du rein, Subvention de soutien à la recherche biomédicale, from 2016-07-01 to 2018-06-30
Data provided by the Université Laval research projects registery