Dr. Patrick Laprise is a regular researcher in the Oncology axis of the CHU of Quebec-Laval University Research Centre. He is also a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at Laval University. His research activities focus on understanding cell polarity in cancer. Dr. Laprise also uses the fruit fly to highlight new strategies to combat tumor progression and cancer-related complications. His works have been published in prestigious journals and have been the subject of several editorial texts. In addition, two of his discoveries have been identified as major breakthroughs by Faculty of 1000.

Understanding the cellular and molecular basis of tumor progression

The vast majority of cancers originate from epithelial tissues. These cover the surface of the body and lining of the internal cavities of organs in order to compartmentalize the body and protect it from its environment. The epithelial cells adopt an asymmetrical morphology, called epithelial polarity, which is absolutely vital to their function. The loss of epithelial polarity contributes to the invasion of cancer cells and the formation of metastases. These are often responsible for the lethality associated with cancer. The identification of proteins contributing to the loss of polarity and the characterization of their biochemical properties makes it possible to identify therapeutic strategies for combating the progression of cancer.

Use of the fruit fly in the identification of oncology therapies

Cachexia occurs in many cancer patients. This systemic syndrome is characterized by a massive loss of muscle and fat tissue, which causes significant morbidity, and may even lead to death. Our ability to understand cachexia with traditional experimental models is limited because this syndrome is difficult to model with cultured cells. Additionally, it is financially and logistically unthinkable to test thousands of potential drugs in mice. It is possible to induce tumor formation and cachexia in fruit flies. This model offers an exceptional opportunity to screen large-scale molecule libraries to identify chemical compounds that prevent tumor formation, as well as cachexia associated with cancer. Indeed, it is easy, fast and inexpensive to work with flies, compared to mammals.

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Québec, Québec
Canada G1R 2J6
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Gendron FP, Mongrain S, Laprise P, McMahon S, Dubois CM, Blais M, Asselin C, Rivard N

The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation.

Journal Article

Am J Physiol Gastrointest Liver Physiol, 290 (2), pp. G310-8, 2006, ISSN: 0193-1857.

Abstract | Links:

Beronja S, Laprise P, Papoulas O, Pellikka M, Sisson J, Tepass U

Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells.

Journal Article

J Cell Biol, 169 (4), pp. 635-46, 2005, ISSN: 0021-9525.

Abstract | Links:

Boucher MJ, Laprise P, Rivard N

Cyclic AMP-dependent protein kinase A negatively modulates adherens junction integrity and differentiation of intestinal epithelial cells.

Journal Article

J Cell Physiol, 202 (1), pp. 178-90, 2005, ISSN: 0021-9541.

Abstract | Links:

23 entries « 3 of 3 »
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