Dr. Patrick Laprise is a regular researcher in the Oncology axis of the CHU of Quebec-Laval University Research Centre. He is also a professor in the Department of Molecular Biology, Medical Biochemistry and Pathology at Laval University. His research activities focus on understanding cell polarity in cancer. Dr. Laprise also uses the fruit fly to highlight new strategies to combat tumor progression and cancer-related complications. His works have been published in prestigious journals and have been the subject of several editorial texts. In addition, two of his discoveries have been identified as major breakthroughs by Faculty of 1000.

Understanding the cellular and molecular basis of tumor progression

The vast majority of cancers originate from epithelial tissues. These cover the surface of the body and lining of the internal cavities of organs in order to compartmentalize the body and protect it from its environment. The epithelial cells adopt an asymmetrical morphology, called epithelial polarity, which is absolutely vital to their function. The loss of epithelial polarity contributes to the invasion of cancer cells and the formation of metastases. These are often responsible for the lethality associated with cancer. The identification of proteins contributing to the loss of polarity and the characterization of their biochemical properties makes it possible to identify therapeutic strategies for combating the progression of cancer.

Use of the fruit fly in the identification of oncology therapies

Cachexia occurs in many cancer patients. This systemic syndrome is characterized by a massive loss of muscle and fat tissue, which causes significant morbidity, and may even lead to death. Our ability to understand cachexia with traditional experimental models is limited because this syndrome is difficult to model with cultured cells. Additionally, it is financially and logistically unthinkable to test thousands of potential drugs in mice. It is possible to induce tumor formation and cachexia in fruit flies. This model offers an exceptional opportunity to screen large-scale molecule libraries to identify chemical compounds that prevent tumor formation, as well as cachexia associated with cancer. Indeed, it is easy, fast and inexpensive to work with flies, compared to mammals.

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23 entries « 2 of 3 »

Gareau C, Houssin E, Martel D, Coudert L, Mellaoui S, Huot ME, Laprise P, Mazroui R

Characterization of fragile X mental retardation protein recruitment and dynamics in Drosophila stress granules.

Journal Article

PLoS ONE, 8 (2), pp. e55342, 2013.

Abstract | Links:

Chartier FJ, Hardy EJ, Laprise P

Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death.

Journal Article

J Cell Biol, 198 (6), pp. 991-8, 2012, ISSN: 0021-9525.

Abstract | Links:

Chartier FJ, Hardy EJ, Laprise P

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.

Journal Article

J Cell Sci, 124 (Pt 20), pp. 3393-8, 2011, ISSN: 0021-9533.

Abstract | Links:

Laprise P, Tepass U

Novel insights into epithelial polarity proteins in Drosophila.

Journal Article

Trends Cell Biol, 21 (7), pp. 401-8, 2011, ISSN: 0962-8924.

Abstract | Links:

Laprise P

Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors.

Journal Article

J Biomed Biotechnol, 2011 , pp. 868217, 2011, ISSN: 1110-7243.

Abstract | Links:

Laprise P, Paul SM, Boulanger J, Robbins RM, Beitel GJ, Tepass U

Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway.

Journal Article

Curr Biol, 20 (1), pp. 55-61, 2010, ISSN: 0960-9822.

Abstract | Links:

Laprise P

[Identification of novel polarity proteins revealed the temporal regulation of the epithelial phenotype].

Journal Article

Med Sci (Paris), 26 (1), pp. 19-21, 2010, ISSN: 0767-0974.

| Links:

Laprise P, Lau KM, Harris KP, Silva-Gagliardi NF, Paul SM, Beronja S, Beitel GJ, McGlade CJ, Tepass U

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.

Journal Article

Nature, 459 (7250), pp. 1141-5, 2009, ISSN: 0028-0836.

Abstract | Links:

Swanson LE, Yu M, Nelson KS, Laprise P, Tepass U, Beitel GJ

Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization.

Journal Article

Genetics, 181 (4), pp. 1281-90, 2009, ISSN: 0016-6731.

Abstract | Links:

Laprise P, Beronja S, Silva-Gagliardi NF, Pellikka M, Jensen AM, McGlade CJ, Tepass U

The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size.

Journal Article

Dev Cell, 11 (3), pp. 363-74, 2006, ISSN: 1534-5807.

Abstract | Links:

23 entries « 2 of 3 »
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