Patrick Couture received his medical degree from Laval University in Quebec City. He completed his residency in Internal Medicine and a PhD in physiology at Laval University and the University of Montreal before heading to Tufts University in Boston, MA, for a research fellowship at the Jean-Mayer USDA Human Nutrition Research Center on Aging. Upon returning to Quebec City, he joined the CHU Research Center and the Institute of Nutrition and Functional Foods, where he contributed to the establishment of a clinical research center focused on nutrition and lipoprotein metabolism. Dr. Couture is currently a professor in Laval University’s School of Medicine, and he was the director of the university’s residency training program in internal medicine from 2007 to 2012. Dr. Couture is currently the director of the Lipid Apheresis Program at the Laval University Medical Center, and he is also involved in the clinical care of patients with various lipoprotein disorders.

Investigate the impact of dietary fatty acids on lipoprotein metabolism in patients with diabetes

Diabetes and pre-diabetes are metabolic disorders affecting more than 15% of the world’s population. The prevalence of these disorders is currently on the rise, mainly due to the increasingly sedentary lifestyles associated with rising obesity rates and aging of the population. Because diabetes and pre-diabetes are so closely associated with major health problems such as high blood pressure, high blood cholesterol and cardiovascular disease, they have a tremendous impact on society’s healthcare costs. Significant efforts should therefore be dedicated to tackling this problem from a societal perspective. Dr. Couture’s interests in nutrition led him to uncover the effects of various dietary fatty acids on lipoprotein kinetics and on the expression of key genes involved in intestinal lipid metabolism in patients with diabetes and pre-diabetes. His work is funded by grants from the Canadian Institutes of Health Research, Fonds de recherche du Québec (Santé) and industry.

Education & certification

1987

  • MD, Laval University, Québec City.
  • License from the College of Physicians of Quebec (General Practice).
  • License from the Medical Council of Canada (L.M.C.C.).
  • FLEX (The Federation Licensing Examination) certification, New York State.

1991

  • MSc in physiology (molecular endocrinology), Laval University, Québec City. Research Project: Regulation of 17ß-hydroxysteroid dehydrogenase activity in human breast cancer. Supervisors: Drs. Jacques Simard and Fernand Labrie.

1992

  • American Board of Internal Medicine certification.

1993

  • Residency in Internal Medicine (1998-1993) at Laval University and University of Montréal. The Royal College of Physicians and Surgeons of Canada certification (Internal Medicine).
  • License of the College of Physicians of Quebec (Internal Medicine).

1997

  • PhD in physiology, Laval University, Québec City. Research project: Molecular genetics and phenotypic expression of familial hypercholesterolemia and protein C deficiency in French Canadians. Supervisors: Drs. Jacques Simard and Sital Moorjani.

1997-99

  • Fellowship, Lipid Metabolism Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. Research project: Genetic polymorphisms associated with variations in plasma lipoproteins and coronary heart disease risk in the Framingham Offspring Study. Supervisors: Drs. Ernst J. Schaefer and Jose Ordovas.
CHUL
2705, boulevard Laurier
C-00102
Québec, Québec
Canada G1V 4G2
226 entries « 22 of 23 »

Couture P, Otvos JD, Cupples LA, Wilson PW, Schaefer EJ, Ordovas JM

Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study.

Journal Article

Atherosclerosis, 148 (2), pp. 337-43, 2000, ISSN: 0021-9150.

Abstract | Links:

Couture P, Otvos JD, Cupples LA, Wilson PW, Schaefer EJ, Ordovas JM

Association of the A-204C polymorphism in the cholesterol 7alpha-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study.

Journal Article

J Lipid Res, 40 (10), pp. 1883-9, 1999, ISSN: 0022-2275.

Abstract | Links:

Couture P, Denault AY, Carignan S, Boudreault D, Babin D, Ruel M

Intraoperative detection of segmental wall motion abnormalities with transesophageal echocardiography.

Journal Article

Can J Anaesth, 46 (9), pp. 827-31, 1999, ISSN: 0832-610X.

Abstract | Links:

Tchernof A, Lévesque E, Beaulieu M, Couture P, Després JP, Hum DW, Bélanger A

Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method.

Journal Article

Clin Endocrinol (Oxf), 50 (5), pp. 637-42, 1999, ISSN: 0300-0664.

Abstract | Links:

Couture P, Morissette J, Gaudet D, Vohl MC, Gagné C, Bergeron J, Després JP, Simard J

Fine mapping of low-density lipoprotein receptor gene by genetic linkage on chromosome 19p13.1-p13.3 and study of the founder effect of four French Canadian low-density lipoprotein receptor gene mutations.

Journal Article

Atherosclerosis, 143 (1), pp. 145-51, 1999, ISSN: 0021-9150.

Abstract | Links:

Gaudet D, Vohl MC, Couture P, Moorjani S, Tremblay G, Perron P, Gagné C, Després JP

Contribution of receptor negative versus receptor defective mutations in the LDL-receptor gene to angiographically assessed coronary artery disease among young (25-49 years) versus middle-aged (50-64 years) men.

Journal Article

Atherosclerosis, 143 (1), pp. 153-61, 1999, ISSN: 0021-9150.

Abstract | Links:

Gaudet D, Gagné C, Perron P, Couture P, Tonstad S

Ethical issues in molecular screening for heterozygous familial hypercholesterolemia: the complexity of dealing with genetic susceptibility to coronary artery disease.

Journal Article

Community Genet, 2 (1), pp. 2-8, 1999, ISSN: 1422-2795.

| Links:

Couture P, Demers C, Morissette J, Delage R, Jomphe M, Couture L, Simard J

Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels.

Journal Article

Thromb Haemost, 80 (4), pp. 551-6, 1998, ISSN: 0340-6245.

Abstract | Links:

Couture P, Brun LD, Szots F, Lelièvre M, Gaudet D, Després JP, Simard J, Lupien PJ, Gagné C

Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia.

Journal Article

Arterioscler Thromb Vasc Biol, 18 (6), pp. 1007-12, 1998, ISSN: 1079-5642.

Abstract | Links:

Couture P, Vohl MC, Gagne C, Gaudet D, Torres AL, Lupien PJ, Després JP, Labrie F, Simard J, Moorjani S

Identification of three mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia among French Canadians.

Journal Article

Hum Mutat, Suppl 1 , pp. S226-31, 1998, ISSN: 1059-7794.

| Links:

226 entries « 22 of 23 »
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Active projects

  • Canada-Wide Human nutrition trialists' network, Subvention, Instituts de recherche en santé du Canada, Subventions de recherche programmatique sur l’alimentation et la santé, from 2014-06-01 to 2021-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en sciences et technologie du lait, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2024-03-05
  • Differential effects of saturated and monounsaturated fatty acids on chylomicron secretion and the expression of key genes that regulate intestinal lipid metabolism in insulin-resistant subjects, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2022-03-31
  • Mediterranean diet and physical activity: is the whole better than the sum of each part ? Clinical and mechanistic perspectives, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Nutrition, santé et société (NUTRISS), Subvention, Fonds de recherche du Québec - Santé, Nouveaux Centres et Instituts de recherche - Subventions régulières, from 2019-04-01 to 2024-03-31
  • Qualité nutritionnelle des aliments et déterminants de l'adhésion aux saines habitudes alimentaires, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds d'innovation (FI), from 2015-12-01 to 2020-12-30
  • The effect of an enhanced dietary portfolio flus exercise on cardiovascular risk in high risk individuals, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2013-10-01 to 2021-03-31

Recently finished projects

  • Réunions scientifiques de médecine du CHUL, Subvention, Alexion Pharmaceuticals, Inc., from 2019-04-01 to 2020-03-31
Data provided by the Université Laval research projects registery