Patrick Couture received his medical degree from Laval University in Quebec City. He completed his residency in Internal Medicine and a PhD in physiology at Laval University and the University of Montreal before heading to Tufts University in Boston, MA, for a research fellowship at the Jean-Mayer USDA Human Nutrition Research Center on Aging. Upon returning to Quebec City, he joined the CHU Research Center and the Institute of Nutrition and Functional Foods, where he contributed to the establishment of a clinical research center focused on nutrition and lipoprotein metabolism. Dr. Couture is currently a professor in Laval University’s School of Medicine, and he was the director of the university’s residency training program in internal medicine from 2007 to 2012. Dr. Couture is currently the director of the Lipid Apheresis Program at the Laval University Medical Center, and he is also involved in the clinical care of patients with various lipoprotein disorders.

Investigate the impact of dietary fatty acids on lipoprotein metabolism in patients with diabetes

Diabetes and pre-diabetes are metabolic disorders affecting more than 15% of the world’s population. The prevalence of these disorders is currently on the rise, mainly due to the increasingly sedentary lifestyles associated with rising obesity rates and aging of the population. Because diabetes and pre-diabetes are so closely associated with major health problems such as high blood pressure, high blood cholesterol and cardiovascular disease, they have a tremendous impact on society’s healthcare costs. Significant efforts should therefore be dedicated to tackling this problem from a societal perspective. Dr. Couture’s interests in nutrition led him to uncover the effects of various dietary fatty acids on lipoprotein kinetics and on the expression of key genes involved in intestinal lipid metabolism in patients with diabetes and pre-diabetes. His work is funded by grants from the Canadian Institutes of Health Research, Fonds de recherche du Québec (Santé) and industry.

Education & certification

1987

  • MD, Laval University, Québec City.
  • License from the College of Physicians of Quebec (General Practice).
  • License from the Medical Council of Canada (L.M.C.C.).
  • FLEX (The Federation Licensing Examination) certification, New York State.

1991

  • MSc in physiology (molecular endocrinology), Laval University, Québec City. Research Project: Regulation of 17ß-hydroxysteroid dehydrogenase activity in human breast cancer. Supervisors: Drs. Jacques Simard and Fernand Labrie.

1992

  • American Board of Internal Medicine certification.

1993

  • Residency in Internal Medicine (1998-1993) at Laval University and University of Montréal. The Royal College of Physicians and Surgeons of Canada certification (Internal Medicine).
  • License of the College of Physicians of Quebec (Internal Medicine).

1997

  • PhD in physiology, Laval University, Québec City. Research project: Molecular genetics and phenotypic expression of familial hypercholesterolemia and protein C deficiency in French Canadians. Supervisors: Drs. Jacques Simard and Sital Moorjani.

1997-99

  • Fellowship, Lipid Metabolism Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA. Research project: Genetic polymorphisms associated with variations in plasma lipoproteins and coronary heart disease risk in the Framingham Offspring Study. Supervisors: Drs. Ernst J. Schaefer and Jose Ordovas.
CHUL
2705, boulevard Laurier
C-00102
Québec, Québec
Canada G1V 4G2
237 entries « 1 of 24 »

Bourgeois R, Girard A, Perrot N, Guertin J, Mitchell PL, Couture C, Gotti C, Bourassa S, Poggio P, Mass E, Capoulade R, Scipione CA, Despres AA, Couture P, Droit A, Pibarot P, Boffa MB, Theriault S, Koschinsky ML, Mathieu P, Arsenault BJ

A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization.

Journal Article

CJC Open, 3 (4), 2021.

Abstract | Links:

Drouin-Chartier JP, Tremblay AJ, Godbout D, Gagnon A, Clavel MA, Clisson M, Arsenault BJ, Pibarot P, Larose E, Couture P

Correlates of Coronary Artery Calcification Prevalence and Severity in Patients With Heterozygous Familial Hypercholesterolemia.

Journal Article

CJC Open, 3 (1), 2021.

Abstract | Links:

Roy G, Boucher A, Couture P, Drouin-Chartier JP

Impact of Diet on Plasma Lipids in Individuals with Heterozygous Familial Hypercholesterolemia: A Systematic Review of Randomized Controlled Nutritional Studies.

Journal Article

Nutrients, 13 (1), 2021.

Abstract | Links:

Vors C, Rancourt-Bouchard M, Couillard C, Gigleux I, Couture P, Lamarche B

Sex May Modulate the Effects of Combined Polyphenol Extract and L-citrulline Supplementation on Ambulatory Blood Pressure in Adults with Prehypertension: A Randomized Controlled Trial.

Journal Article

Nutrients, 13 (2), 2021.

Abstract | Links:

Pearson GJ, Thanassoulis G, Anderson TJ, Barry AR, Couture P, Dayan N, Francis GA, Genest J, Grégoire J, Grover SA, Gupta M, Hegele RA, Lau D, Leiter LA, Leung AA, Lonn E, Mancini GBJ, Manjoo P, McPherson R, Ngui D, Piché ME, Poirier P, Sievenpiper J, Stone J, Ward R, Wray W

2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults.

Journal Article

Can J Cardiol, 37 (8), 2021.

Abstract | Links:

Mutch DM, Lowry DE, Roth M, Sihag J, Hammad SS, Taylor CG, Zahradka P, Connelly PW, West SG, Bowen K, Kris-Etherton PM, Lamarche B, Couture P, Guay V, Jenkins DJ, Eck P, Jones PJ

Polymorphisms in the stearoyl-CoA desaturase gene modify blood glucose response to dietary oils varying in MUFA content in adults with obesity.

Journal Article

Br J Nutr, 2021.

Abstract | Links:

Rajendiran E, She Y, Ramprasath V, Eck P, Gigleux I, Levy E, Tremblay A, Couture P, House JD, Jones PJH, Lamarche B, Brassard D, Desmarchelier C

A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial.

Journal Article

Am J Clin Nutr, 114 (2), 2021.

Abstract | Links:

Bourgeois R, Devillers R, Perrot N, Despres AA, Boulanger MC, Mitchell PL, Guertin J, Couture P, Boffa MB, Scipione CA, Pibarot P, Koschinsky ML, Mathieu P, Arsenault BJ

Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.

Journal Article

JACC Basic Transl Sci, 5 (9), 2020.

Abstract | Links:

Franck M, de Toro-Martin J, Guenard F, Rudkowska I, Lemieux S, Lamarche B, Couture P, Vohl MC

Prevention of Potential Adverse Metabolic Effects of a Supplementation with Omega-3 Fatty Acids Using a Genetic Score Approach.

Journal Article

Lifestyle Genom, 13 (1), 2020.

Abstract | Links:

Lalande C, Drouin-Chartier JP, Tremblay AJ, Couture P, Veilleux A

Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations.

Journal Article

Diabetol Metab Syndr, 12 , 2020.

Abstract | Links:

237 entries « 1 of 24 »
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Active projects

  • Canada-Wide Human nutrition trialists' network, from 2014-06-01 to 2023-03-31
  • Differential effects of saturated and monounsaturated fatty acids on chylomicron secretion and the expression of key genes that regulate intestinal lipid metabolism in insulin-resistant subjects, from 2019-04-01 to 2022-03-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.1, from 2019-11-01 to 2024-10-31
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3, from 2019-11-01 to 2024-10-31
  • Indices de qualité nutritionnelle et calcification des artères coronaires dans une cohorte d'individus avec hypercholestérolémie familiale hétérozygote, from 2021-02-02 to 2022-03-31
  • Mediterranean diet and physical activity: is the whole better than the sum of each part ? Clinical and mechanistic perspectives, from 2018-04-01 to 2024-03-31
  • Plant-based dietary patterns and coronary artery calcification in adults with heterozygous familial hypercholesterolemia, from 2021-04-01 to 2022-03-31

Recently finished projects

  • Homozygous familial hypercholesterolemia (HoFH) in Canada, from 2019-12-01 to 2020-03-31
  • Qualité nutritionnelle des aliments et déterminants de l'adhésion aux saines habitudes alimentaires, from 2015-12-01 to 2021-09-30
  • Réunions scientifiques de médecine du CHUL, from 2019-04-01 to 2020-03-31
  • The effect of an enhanced dietary portfolio flus exercise on cardiovascular risk in high risk individuals, from 2013-10-01 to 2021-03-31
Data provided by the Université Laval research projects registery