Dr. Dupré is a neurologist at the CHU de Québec-Laval University, an Associate Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.
Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.
The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.
Département des sciences neurologiques
Canada G1J 1Z4
Genetic susceptibility of Alzheimer's disease in East Asia.Journal Article
Can J Neurol Sci, 38 (3), pp. 394-5, 2011, ISSN: 0317-1671.
Analysis of OPTN as a causative gene for amyotrophic lateral sclerosis.Journal Article
Neurobiol Aging, 32 (3), pp. 555.e13-4, 2011, ISSN: 0197-4580.
Identification of a FUS splicing mutation in a large family with amyotrophic lateral sclerosis.Journal Article
J Hum Genet, 56 (3), pp. 247-9, 2011, ISSN: 1434-5161.
Identification of novel FUS mutations in sporadic cases of amyotrophic lateral sclerosis.Journal Article
Amyotroph Lateral Scler, 12 (2), pp. 113-7, 2011, ISSN: 1748-2968.
A mutation in the RNF170 gene causes autosomal dominant sensory ataxia.Journal Article
Brain, 134 (Pt 2), pp. 602-7, 2011, ISSN: 0006-8950.
LINGO1 variants in the French-Canadian population.Journal Article
PLoS ONE, 6 (1), pp. e16254, 2011.
Cognitive impairment in ARCA-1, a newly discovered pure cerebellar ataxia syndrome.Journal Article
Cerebellum, 9 (3), pp. 443-53, 2010, ISSN: 1473-4222.
Familial Alzheimer disease in Canada.Journal Article
Can J Neurol Sci, 37 (3), pp. 302-3, 2010, ISSN: 0317-1671.
Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis.Journal Article
Proc Natl Acad Sci U S A, 106 (51), pp. 21777-82, 2009, ISSN: 0027-8424.
A novel TYMP mutation in a French Canadian patient with mitochondrial neurogastrointestinal encephalomyopathy.Journal Article
Clin Neurol Neurosurg, 111 (8), pp. 691-4, 2009, ISSN: 0303-8467.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-12-31
- Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
- Projet de recherche clinique en sciences neurologiques (Bourse de recherche pour Vincent Clément) , Subvention, Fondation du CHU de Québec, from 2019-10-31 to 2020-10-29
- The Canadian Parkinson Network, Subvention, Brain Canada Foundation, from 2018-10-01 to 2021-09-30
Recently finished projects
- (FRQS 85493) Projet 2016-2792 pour les activités de recrutement, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2019-04-04 to 2020-03-31
- Acquisition de matériel biologique pour la recherche sur la sclérose en plaque amyotrophique, de même que la formation du personnel , Subvention, Fondation du CHU de Québec, from 2019-11-19 to 2020-03-31
- Genetic modifiers of GBA-associated Parkinson's disease, Subvention, Michael J. Fox Foundation for Parkinson's Research, from 2018-07-01 to 2019-12-31
- Projet de recherche portant sur une maladie héréditaire orpheline, Subvention, Le Grand Défi Pierre Lavoie, from 2018-10-01 to 2019-09-30
- Reprogramming hiPSCs from ARSACS patients into neural cells in order to recreate a model of the disease in vitro, Subvention, National Ataxia Foundation, from 2019-03-01 to 2020-02-29
- Réseau Parkinson Québec / Quebec Parkinson Network, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2016-04-01 to 2020-03-31