Dr. Dupré is a neurologist at the CHU de Québec-Laval University, an Associate Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.
Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.
The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.
Département des sciences neurologiques
Canada G1J 1Z4
- Gagné, FrançoiseEmployee+1 418-525-4444, extension firstname.lastname@example.org
- Lamontagne, RémyMaster studentHôpital de l'Enfant-Jésus+1 email@example.com@crchudequebec.ulaval.ca
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CMDGT / LOEX
Canada G1J 1Z4
- Martineau, LaurenceFellowlaurence.firstname.lastname@example.org
- Masson-Roy, JoséeFellowjosee.email@example.com
- Stumpf, MonicaInternmonica.firstname.lastname@example.org@crchudequebec.ulaval.ca
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.Journal Article
Ann Neurol, 87 (4), pp. 584-598, 2020, ISSN: 0364-5134.
Characterization of the phenotype with cognitive impairment and protein mislocalization in SCA34.Journal Article
Neurol Genet, 6 (2), pp. e403, 2020, ISSN: 2376-7839.
Clinical and genetic analysis of ATP13A2 in hereditary spastic paraplegia expands the phenotype.Journal Article
Mol Genet Genomic Med, 8 (3), pp. e1052, 2020.
Analysis of common and rare VPS13C variants in late-onset Parkinson disease.Journal Article
Neurol Genet, 6 (1), pp. 385, 2020, ISSN: 2376-7839.
Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.Journal Article
Ann Neurol, 87 (1), pp. 139-153, 2020, ISSN: 0364-5134.
The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.Journal Article
J Parkinsons Dis, 10 (1), pp. 301-313, 2020, ISSN: 1877-7171.
The Classification of Autosomal Recessive Cerebellar Ataxias: a Consensus Statement from the Society for Research on the Cerebellum and Ataxias Task Force.Journal Article
Cerebellum, 18 (6), pp. 1098-1125, 2019, ISSN: 1473-4222.
SPTAN1 variants as a potential cause for autosomal recessive hereditary spastic paraplegia.Journal Article
J Hum Genet, 64 (11), pp. 1145-1151, 2019, ISSN: 1434-5161.
Absence of Mutation Enrichment for Genes Phylogenetically Conserved in the Olivocerebellar Motor Circuitry in a Cohort of Canadian Essential Tremor Cases.Journal Article
Mol Neurobiol, 56 (6), pp. 4317-4321, 2019, ISSN: 0893-7648.
Common and rare GCH1 variants are associated with Parkinson's disease.Journal Article
Neurobiol Aging, 73 , pp. 231.e1-231.e6, 2019, ISSN: 0197-4580.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
- Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
- The Canadian Parkinson Network, Subvention, Brain Canada Foundation, from 2018-10-01 to 2021-09-30
Recently finished projects
- (FRQS 85493) Projet 2016-2792 pour les activités de recrutement, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2019-04-04 to 2020-03-31
- (FRSQ 83746) Projet de recherche portant sur une maladie héréditaire orpheline, Subvention, Le Grand Défi Pierre Lavoie, from 2018-10-01 to 2019-09-30
- Canadian Consortium on Neurodegeneration in Aging - Full proposal, Subvention, Instituts de recherche en santé du Canada, Consortium canadien en neurodégénérescence et vieillissement (CCNV), from 2014-04-01 to 2019-03-31
- Genetic modifiers of GBA-associated Parkinson's disease, Subvention, Michael J. Fox Foundation for Parkinson's Research, from 2018-07-01 to 2019-12-31
- Human inducible pluripotent stem cells (IPSC) plateform, Subvention, La Fondation Neuro Canada / Brain Canada, Soutien aux plateformes technologiques (SSPT), from 2015-04-01 to 2018-09-30
- Reprogramming hiPSCs from ARSACS patients into neural cells in order to recreate a model of the disease in vitro, Subvention, National Ataxia Foundation, from 2019-03-01 to 2020-02-29