Dr. Dupré is a neurologist at the CHU de Québec-Laval University, an Associate Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.

Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.

The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.

1401, 18e Rue
Département des sciences neurologiques
Québec, Québec
Canada G1J 1Z4
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Gamache PL, Salem IH, Roux-Dubois N, Le Bouthillier J, Gan-Or Z, Dupre N

Exposure to pesticides and welding hastens the age-at-onset of Parkinson's disease.

Journal Article

Can J Neurol Sci, pp. 1-17, 2019, ISSN: 0317-1671.

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Beaudin M, Matilla-Duenas A, Soong BW, Pedroso JL, Barsottini OG, Mitoma H, Tsuji S, Schmahmann JD, Manto M, Rouleau GA, Klein C, Dupre N

The Classification of Autosomal Recessive Cerebellar Ataxias: a Consensus Statement from the Society for Research on the Cerebellum and Ataxias Task Force.

Journal Article

Cerebellum, 2019, ISSN: 1473-4222.

Abstract | Links:

Schmouth JF, Houle G, Ambalavanan A, Leblond CS, Spiegelman D, Laurent SB, Bourassa CV, Panisset M, Chouinard S, Dupre N, Vilarino-Guell C, Rajput A, Dion PA, Rouleau GA

Absence of Mutation Enrichment for Genes Phylogenetically Conserved in the Olivocerebellar Motor Circuitry in a Cohort of Canadian Essential Tremor Cases.

Journal Article

Mol Neurobiol, 56 (6), pp. 4317-4321, 2019, ISSN: 0893-7648.

Abstract | Links:

Rudakou U, Ouled Amar Bencheikh B, Ruskey JA, Krohn L, Laurent SB, Spiegelman D, Liong C, Fahn S, Waters C, Monchi O, Fon EA, Dauvilliers Y, Alcalay RN, Dupre N, Gan-Or Z

Common and rare GCH1 variants are associated with Parkinson's disease.

Journal Article

Neurobiol Aging, 73 , pp. 231.e1-231.e6, 2019, ISSN: 0197-4580.

Abstract | Links:

Lamontagne-Proulx J, St-Amour I, Labib R, Pilon J, Denis HL, Cloutier N, Roux-Dalvai F, Vincent AT, Mason SL, Duchez AC, Droit A, Lacroix S, Dupre N, Langlois M, Chouinard S, Panisset M, Barker RA, Boilard E, Cicchetti F

Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease.

Journal Article

Neurobiol Dis, 124 , pp. 163-175, 2019, ISSN: 0969-9961.

Abstract | Links:

Alcalay RN, Mallett V, Vanderperre B, Tavassoly O, Dauvilliers Y, Wu RYJ, Ruskey JA, Leblond CS, Ambalavanan A, Laurent SB, Spiegelman D, Dionne-Laporte A, Liong C, Levy OA, Fahn S, Waters C, Kuo SH, Chung WK, Ford B, Marder KS, Kang UJ, Hassin-Baer S, Greenbaum L, Trempe JF, Wolf P, Oliva P, Zhang XK, Clark LN, Langlois M, Dion PA, Fon EA, Dupre N, Rouleau GA, Gan-Or Z

SMPD1 mutations, activity, and α-synuclein accumulation in Parkinson's disease.

Journal Article

Mov Disord, 34 (4), pp. 526-535, 2019, ISSN: 0885-3185.

Abstract | Links:

Ruskey JA, Zhou S, Santiago R, Franche LA, Alam A, Ronciere L, Spiegelman D, Fon EA, Trempe JF, Kalia LV, Postuma RB, Dupre N, Rivard GE, Assouline S, Amato D, Gan-Or Z

The GBA p.Trp378Gly mutation is a probable French-Canadian founder mutation causing Gaucher disease and synucleinopathies.

Journal Article

Clin Genet, 94 (3-4), pp. 339-345, 2018, ISSN: 0009-9163.

Abstract | Links:

Giguere-Rancourt A, Plourde M, Doiron M, Langlois M, Dupre N, Simard M

Goal management training ® home-based approach for mild cognitive impairment in Parkinson's disease: a multiple baseline case report.

Journal Article

Neurocase, 24 (5-6), pp. 276-286, 2018, ISSN: 1355-4794.

Abstract | Links:

Pare B, Lehmann M, Beaudin M, Nordstrom U, Saikali S, Julien JP, Gilthorpe JD, Marklund SL, Cashman NR, Andersen PM, Forsberg K, Dupre N, Gould P, Brannstrom T, Gros-Louis F

Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis.

Journal Article

Sci Rep, 8 (1), pp. 14223, 2018, ISSN: 2045-2322.

Abstract | Links:

Zhou S, Gan-Or Z, Ambalavanan A, Lai D, Xie P, Bourassa CV, Strong S, Ross JP, Dionne-Laporte A, Spiegelman D, Dupre N, Foroud TM, Xiong L, Dion PA, Rouleau GA

Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population.

Journal Article

Sci Rep, 8 (1), pp. 4356, 2018, ISSN: 2045-2322.

Abstract | Links:

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Active projects

  • (FRQS 85493) Projet 2016-2792 pour les activités de recrutement, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2019-04-04 to 2020-03-31
  • (FRSQ 83746) Projet de recherche portant sur une maladie héréditaire orpheline, Subvention, Le Grand Défi Pierre Lavoie, from 2018-10-01 to 2019-09-30
  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Genetic modifiers of GBA-associated Parkinson's disease, Subvention, Michael J. Fox Foundation for Parkinson's Research, from 2018-07-01 to 2019-12-31
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
  • Reprogramming hiPSCs from ARSACS patients into neural cells in order to recreate a model of the disease in vitro, Subvention, National Ataxia Foundation, from 2019-03-01 to 2020-02-29
  • The Canadian Parkinson Network, Subvention, Brain Canada Foundation, from 2018-10-01 to 2021-09-30

Recently finished projects

  • Canadian Consortium on Neurodegeneration in Aging - Full proposal, Subvention, Instituts de recherche en santé du Canada, Consortium canadien en neurodégénérescence et vieillissement (CCNV), from 2014-04-01 to 2019-03-31
  • Human inducible pluripotent stem cells (IPSC) plateform, Subvention, La Fondation Neuro Canada / Brain Canada, Soutien aux plateformes technologiques (SSPT), from 2015-04-01 to 2018-09-30
Data provided by the Université Laval research projects registery