Dr. Dupré is a neurologist at the CHU de Québec-Laval University, an Associate Professor in the Department of Medicine of the School of Medicine (Laval University), and the Director of the Neuromuscular and Neurogenetic Disease Clinic of the CHU de Québec – Université Laval.
Dr. Dupré completed his medical training at McGill University and his residency in neurology at Laval University. He completed his postdoctoral training at the Montreal Neurological Hospital and Institute and at Harvard University. In 2007, he discovered a gene (syne-1) implicated in a new form of hereditary ataxia that has since been highly recognized internationally. Dr. Dupré also played an important role in the discovery of the involvement of the TARDBP in the etiology of amyotrophic lateral sclerosis. He is now involved in several provincial, national, and international networks that contribute to the discovery of genes involved in neurological diseases. He has generated more than 100 original publications. Dr. Dupré’s remarkable achievements have earned him several awards, including the 2015 Quebec Society of Muscular Dystrophy Award – ALS component – related to his involvement in the Clinic for Neuromuscular and Neurogenetic Diseases.
The research component of the clinic has grown significantly in recent years, with the creation of the Québec Parkinson Network (rpq-qpn.ca). The network connects clinicians with basic science researchers in the field, giving access to a registry of nearly 1000 patients. In addition to his clinical program, Dr. Dupré is involved in research projects linking clinical and basic research. This is done in collaboration with Dr. François Gros-Louis, of the LOEX research center at CHU de Québec – Laval University. One of these projects aims to discover biomarkers of amyotrophic lateral sclerosis in the skin. Another important project Dr. Dupré takes part in focuses on the development of a reconstructed skin model to study neurofibromatosis. Finally, Dr. Dupré is actively collaborating with Dr. Gros-Louis to identify pathogenic mechanisms of intracranial aneurysms in the Inuit and French-Canadian populations and to develop in vitro models of the disease. This project has just been funded by CIHR for a duration of 5 years.
Département des sciences neurologiques
Canada G1J 1Z4
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Genetic testing for amyotrophic lateral sclerosis in Canada - an assessment of current practices.Journal Article
Amyotroph Lateral Scler Frontotemporal Degener, 2021.
Clinical perception and management of Parkinson's disease during the COVID-19 pandemic: A Canadian experience.Journal Article
Parkinsonism Relat Disord, 91 , 2021.
Chemosensory Dysfunctions Induced by COVID-19 Can Persist up to 7 Months: A Study of Over 700 Healthcare Workers.Journal Article
Chem Senses, 46 , 2021.
The Canadian Neuromuscular Disease Registry 2010-2019: A Decade of Facilitating Clinical Research Througha Nationwide, Pan-NeuromuscularDisease Registry.Journal Article
J Neuromuscul Dis, 8 (1), 2021.
Biofabrication of a three dimensional human-based personalized neurofibroma model.Journal Article
Biotechnol J, 16 (6), 2021.
Evidence for Non-Mendelian Inheritance in Spastic Paraplegia 7.Journal Article
Mov Disord, 36 (7), 2021.
Analysis of Heterozygous PRKN Variants and Copy-Number Variations in Parkinson's Disease.Journal Article
Mov Disord, 36 (1), 2021.
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.Journal Article
Neurobiol Aging, 100 , 2021.
GCH1 mutations in hereditary spastic paraplegia.Journal Article
Clin Genet, 100 (1), 2021.
Altered Theory of Mind in Parkinson's Disease and Impact on Caregivers: A Pilot Study.Journal Article
Can J Neurol Sci, 2021.
- Creating an Open Science Repository of ARCA1 iPSCs, from 2021-05-31 to 2023-05-31
- Creating an Open Science Repository of ARSACS hiPSCs, from 2020-10-23 to 2021-10-22
- Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS, from 2021-02-01 to 2023-01-31
- Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, from 2017-04-01 to 2022-03-31
- The Canadian Parkinson Network, from 2018-10-01 to 2022-09-30
Recently finished projects
- Acquisition de matériel biologique pour la recherche sur la sclérose en plaque amyotrophique, de même que la formation du personnel , from 2019-11-19 to 2020-03-31
- Genetic modifiers of GBA-associated Parkinson's disease, from 2018-07-01 to 2019-12-31
- Projet 2016-2792 pour les activités de recrutement, from 2019-04-04 to 2021-03-31
- Projet de recherche clinique en sciences neurologiques (Bourse de recherche pour Vincent Clément) , from 2019-10-31 to 2020-10-29
- Projet de recherche portant sur une maladie héréditaire orpheline, from 2018-10-01 to 2019-09-30
- Reprogramming hiPSCs from ARSACS patients into neural cells in order to recreate a model of the disease in vitro, from 2019-03-01 to 2020-02-29
- Réseau Parkinson Québec / Quebec Parkinson Network, from 2016-04-01 to 2020-03-31