Dr. Nicolas Bisson holds the Canada Research Chair in Proteomics of Cancer. He is an associate professor in the Department of Molecular Biology, Medical Biochemistry and Pathology of the School of Medicine at Laval University, and a regular researcher at the CHU Research Center of Québec – Laval University. He is also a member of the Laval University Cancer Research Center and the Quebec Network for Research on Protein Function, Engineering, and Applications (PROTEO). Dr. Bisson’s work aims to decipher how cells communicate with each other, and how these signaling mechanisms are deregulated in the development of cancers, particularly in the breast and prostate. In the longer term, the goal of his work is to use entire signaling networks as predictive and therapeutic tools for these cancers, in cases for which conventional strategies fail.

 

Communication between the cells that form the tissues of our body is of paramount importance. This dialogue is required, not only to ensure that all body parts develop normally as a result of conception, but also that they function properly throughout our lives. Deregulation of cells to send, receive or correctly assimilate signals from their environment (or other cells) can lead to diseases such as cancer. The cellular actors who assume these tasks are the proteins. Most proteins do not work alone: ​​they combine in pairs, or in small (complexes) or large groups (networks). Dr. Bisson’s team is particularly interested in a group of proteins, called adapters, whose primary function is to associate with different proteins (and with each other) in order to help the cell integrate signals from outside and respond adequately. More particularly, they study the signals received by a family of receptors called tyrosine kinase. Through their work, they aim to identify which cell proteins associate with adapters to form complexes and networks, as well as the mechanisms used by the cell to regulate this non-random process. In addition, they aim to analyze how the composition of complexes varies when the cell receives different signals through tyrosine kinase receptors. Finally, they want to determine if the large protein networks are modified in breast and prostate cancer cells, identify what these changes are, and figure out how it is possible to return them to a normal state. To achieve these goals, the team uses innovative proteomics tools to separate and quantify proteins, cell imaging to observe them, animal models of breast or prostate cancer, and patient samples. Their work will provide new insights into protein networks that are essential to cell communication and life, and how they can be used as prognostic tools or therapeutic targets for the treatment of breast and prostate cancer.

 

Dr. Bisson’s work is funded by the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, and the Canada Foundation for Innovation.

 

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Filteau M, Diss G, Torres-Quiroz F, Dube AK, Schraffl A, Bachmann VA, Gagnon-Arsenault I, Chretien AE, Steunou AL, Dionne U, Cote J, Bisson N, Stefan E, Landry CR

Systematic identification of signal integration by protein kinase A.

Journal Article

Proc Natl Acad Sci U S A, 112 (14), pp. 4501-6, 2015, ISSN: 0027-8424.

Abstract | Links:

Gamblin CL, Hardy EJ, Chartier FJ, Bisson N, Laprise P

A bidirectional antagonism between aPKC and Yurt regulates epithelial cell polarity.

Journal Article

J Cell Biol, 204 (4), pp. 487-95, 2014, ISSN: 0021-9525.

Abstract | Links:

Sabbagh L, Andreeva D, Laramee GD, Oussa NA, Lew D, Bisson N, Soumounou Y, Pawson T, Watts TH

Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.

Journal Article

J Leukoc Biol, 93 (5), pp. 713-21, 2013, ISSN: 0741-5400.

Abstract | Links:

Bisson N, Wedlich D, Moss T

The p21-activated kinase Pak1 regulates induction and migration of the neural crest in Xenopus.

Journal Article

Cell Cycle, 11 (7), pp. 1316-24, 2012, ISSN: 1538-4101.

Abstract | Links:

Huot ME, Bisson N, Moss T, Khandjian EW

Manipulating the fragile X mental retardation proteins in the frog.

Journal Article

Results Probl Cell Differ, 54 , pp. 165-79, 2012, ISSN: 0080-1844.

Abstract | Links:

Bisson N, Ruston J, Jeansson M, Vanderlaan R, Hardy WR, Du J, Hussein SM, Coward RJ, Quaggin SE, Pawson T

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.

Journal Article

PLoS ONE, 7 (11), pp. e50996, 2012.

Abstract | Links:

Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

Journal Article

Nat Biotechnol, 29 (7), pp. 653-8, 2011, ISSN: 1087-0156.

Abstract | Links:

Nagel M, Luu O, Bisson N, Macanovic B, Moss T, Winklbauer R

Role of p21-activated kinase in cell polarity and directional mesendoderm migration in the Xenopus gastrula.

Journal Article

Dev Dyn, 238 (7), pp. 1709-26, 2009, ISSN: 1058-8388.

Abstract | Links:

Bisson N, Tremblay M, Robinson F, Kaplan DR, Trusko SP, Moss T

Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.

Journal Article

Cell Cycle, 7 (7), pp. 909-16, 2008, ISSN: 1538-4101.

Abstract | Links:

Bisson N, Poitras L, Mikryukov A, Tremblay M, Moss T

EphA4 signaling regulates blastomere adhesion in the Xenopus embryo by recruiting Pak1 to suppress Cdc42 function.

Journal Article

Mol Biol Cell, 18 (3), pp. 1030-43, 2007, ISSN: 1059-1524.

Abstract | Links:

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Active projects

  • Analyse protéomique des réseaux de signalisation dépendants des récepteurs tyrosine kinase de la famille EPH et de leurs fonctions dans la ségrégation cellulaire et la polarité épitheliale, Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2018-04-01 to 2021-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Chaire de recherche du Canada en Protéomique du Cancer, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Allocation de recherche pour les Chaires de recherche du Canada Niveau 2 aux premiers termes, from 2019-01-11 to 2020-09-30
  • Chaire de recherche du Canada en Protéomique du Cancer, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2015-10-01 to 2020-10-01
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2015-04-01 to 2022-03-31
  • Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2014-05-01 to 2023-04-03
  • Regulation of oncogenic receptor tyrosine kinase signalling networks by protein phosphorylation, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2024-03-31
  • Understanding the specificity and regulation of NCK adaptor proteins, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2018-04-01 to 2023-03-31

Recently finished projects

  • High throughput analysis of protein interactions and modifications using peptide arrays, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2019-03-28 to 2020-03-31
Data provided by the Université Laval research projects registery