A pharmacist by training, Dr. Nicolas Bertrand is an assistant professor at Laval University’s School of Pharmaceutical Studies. He is also a researcher in the department of Endocrinology and Nephrology at the CHU de Quebec Research Center. His research in nanomedicine focuses on potentiating the efficacy of therapeutic molecules by using nanotechnologies. He is the editor of the European Journal of Pharmaceutics and Biopharmaceutics (Elsevier, IF: 4.2) and director of the « Biopharmacy et pharmacometrics » strategic cluster of the Réseau Québécois de Recherche sur les Médicaments (rqrm.ca). He is an associate member of the Institute on Nutraceuticals and Functional Foods (INAF) and of the Centre de Recherche sur les Matériaux Avancés (CERMA).

Encapsulating bioactive molecules through differentiated technologies

Many drugs in development, or already on the market, possess suboptimal physiochemical or pharmacological characteristics. Nanomedicine can harness the unique features of nanomaterials to facilitate the administration of these drugs, or potentiate their efficacy. Encapsulation of bioactive molecules in nanoparticles can prevent their metabolism, ameliorate their pharmacokinetics, or ensure their optimal distribution to diseased tissues. Altogether, these effects can pave the way for more efficient and better tolerated drugs.

Dr. Nicolas Bertrand’s laboratory uses functional polymers and lipids to encapsulate a variety of bioactive molecules in clinically-relevant drug delivery vehicles.

Elucidate the interactions of nanomaterials with the immune system

Like other drugs, the use of nanoparticles as drug delivery vehicles can trigger unexpected or undesirable reactions. The type of system, its size, or the materials used in its preparation can all influence the nature and extent of its interactions with the immune system. The development of better tolerated nanomedicines necessitates a better understanding of how drug delivery platforms interact with the various components of the immune system.

Through a unique expertise in the preparation of nanoparticle libraries, combined with an established knowledge in preclinical pharmacokinetics, Dr. Nicolas Bertrand’s laboratory specialises in studying the fate of nano- and biomaterials in living animals. This approach leads to an integrated understanding of the interactions of materials with complete, functional biological systems.

CHUL
2705, boulevard Laurier
T4-13
Québec, Québec
Canada G1V 4G2
34 entries « 1 of 4 »

Roussel S, Defrene J, Lima EM, Barabe F, Bertrand N, Viana IMO

Innate and adaptive immune responses toward nanomedicines.

Journal Article

Acta Pharm Sin B, 11 (4), 2021.

Abstract | Links:

Hacene YC, Loiseau A, Maio VDP, Grenier P, Boisselier E, Bertrand N

Isolating Nanoparticles from Complex Biological Media by Immunoprecipitation.

Journal Article

Nano Lett, 21 (11), 2021.

Abstract | Links:

Viana IMO, Grenier P, Defrene J, Barabe F, Lima EM, Bertrand N

Role of the complement cascade in the biological fate of liposomes in rodents.

Journal Article

Nanoscale, 12 (36), 2020.

Abstract | Links:

Chotard E, Mohammadi F, Julien P, Berthiaume L, Rudkowska I, Bertrand N

Drinkable lecithin nanovesicles to study the biological effects of individual hydrophobic macronutrients and food preferences.

Journal Article

Food Chem, 322 , 2020.

Abstract | Links:

Dikpati A, Mohammadi F, Greffard K, Queant C, Arnaud P, Bastiat G, Rudkowska I, Bertrand N

Residual Solvents in Nanomedicine and Lipid-Based Drug Delivery Systems: a Case Study to Better Understand Processes.

Journal Article

Pharm Res, 37 (8), 2020.

Abstract | Links:

O'Connor S, Chaouch IR, Rudkowska I, Bertrand N

Nanotechnologies dans le domaine agroalimentaire : que devons-nous savoir 

Journal Article

Nutr sci évol, 16 , 2019.

Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D

Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model.

Journal Article

Invest New Drugs, 37 (3), 2019.

Abstract | Links:

Ouellette M, Masse F, Lefebvre-Demers M, Maestracci Q, Grenier P, Millar R, Bertrand N, Prieto M, Boisselier E

Insights into gold nanoparticles as a mucoadhesive system.

Journal Article

Sci Rep, 8 (1), 2018.

Abstract | Links:

Bisso PW, Tai M, Katepalli H, Bertrand N, Blankschtein D, Langer R

Molecular Rotors for Universal Quantitation of Nanoscale Hydrophobic Interfaces in Microplate Format.

Journal Article

Nano Lett, 18 (1), 2018.

Abstract | Links:

Grenier P, Lima EM, Bertrand N, Viana IMO

Anti-polyethylene glycol antibodies alter the protein corona deposited on nanoparticles and the physiological pathways regulating their fate in vivo.

Journal Article

J Control Release, 287 , 2018.

Abstract | Links:

34 entries « 1 of 4 »
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Active projects

  • Engineering functional nanoparticles using libraries of polymers, from 2016-04-01 to 2022-03-31
  • Étude des échantillons de sang prélevés avant et après la vaccination contre la Covid-19, from 2021-04-30 to 2022-03-31
  • Nanopharmacologie et nanomédecine : vers le développement de plates-formes technologiques pour la vectorisation des médicaments, from 2018-07-01 to 2022-06-30
  • Nanopharmacologie et nanomédecine: vers le développement de plates-formes technologiques pour la vectorisation des médicaments, from 2018-07-01 to 2022-06-30
  • Un nano-vaccin contre les maladies cardiovasculaires, from 2020-04-01 to 2022-03-31
  • Use of nanoparticles to understand and treat vascular calcification in chronic kidney disease, from 2020-10-01 to 2022-09-30

Recently finished projects

  • Designing quality control strategies to assess the self-assembly and biological stability of chitosan nanoparticles, from 2018-05-01 to 2021-06-30
  • Envisager une protection contre le passage des perturbateurs endocriniens à travers la peau, from 2019-02-01 to 2020-12-31
  • Financement pour la formation d'une étudiante au doctorat, from 2019-06-17 to 2020-03-31
  • Interactions non-covalentes pour l'isolation des nanoparticules, from 2018-04-01 to 2020-03-31
  • Prevention of glioblastoma recurrence by injection in the resection cavity of a hydrogel formed by targeted lipid nanocapsules loaded with anticancer drugs, GLIOGEL, from 2018-04-01 to 2021-03-31
  • Profil toxicologique de nanosphères de silice comme vecteur pharmaceutique, from 2019-10-01 to 2021-03-11
Data provided by the Université Laval research projects registery