Enthused by her bachelor’s degree in Physics, Dr. Desjardins obtained her PhD in biomedical engineering from Université Pierre et Marie Curie (Paris 6) and École Polytechnique de Montréal, followed by a post-doctoral training at the University of California in San Diego. She is now an Assistant Professor in the Département de physique, de génie physique, et d’optique at Université Laval and a researcher at the Centre de Recherche du CHU de Québec-Université Laval. Her research focuses on the imaging of vasculature and oxygenation.

A window on the brain

Our cells need oxygen to function. A change in tissue oxygenation levels can thus be a sign of various pathologies. However, to this day, few methods are available to directly measure oxygenation in biological tissues. Dr. Desjardins’ research takes advantage of a newly developed technique to measure oxygenation in mouse brain using two-photon microscopy. This method allows us to observe the development of physiological or pathological phenomena with time. She also develops biophysical models describing the links between blood flow, oxygenation, and metabolism.

In her lab, these methods are used to study the link between neuronal activity, oxygenation, and blood flow in the brain. This application is made possible by combining oxygenation measurement with light stimulation of neurons in the brains of genetically-modified mice. Another application is following the development of a tumor in a mouse cancer model. By observing the evolution of tumor blood vessels and their effect on oxygenation levels, this research will improve our understanding of the mechanisms of tumor development, with the hope of guiding future therapies.

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18 entries « 1 of 2 »

Li B, Esipova TV, Sencan I, Kilic K, Fu B, Desjardins M, Moeini M, Kura S, Yaseen MA, Lesage F, Ostergaard L, Devor A, Boas DA, Vinogradov SA, Sakadzic S

More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction.

Journal Article

Elife, 8 , 2019, ISSN: 2050-084X.

Abstract | Links:

Desjardins M, Kilic K, Thunemann M, Mateo C, Holland D, Ferri CGL, Cremonesi JA, Li B, Cheng Q, Weldy KL, Saisan PA, Kleinfeld D, Komiyama T, Liu TT, Bussell R, Wong EC, Scadeng M, Dunn AK, Boas DA, Sakadzic S, Mandeville JB, Buxton RB, Dale AM, Devor A

Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level-Dependent Functional Magnetic Resonance Imaging.

Journal Article

Biol Psychiatry Cogn Neurosci Neuroimaging, 4 (6), pp. 533-542, 2019, ISSN: 2451-9022.

Abstract | Links:

Desjardins M

Causality as a New Paradigm in Brain Science.

Journal Article

Biol Psychiatry Cogn Neurosci Neuroimaging, 4 (6), pp. 506-507, 2019, ISSN: 2451-9022.

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Genois E, Gagnon L, Guilbert J, Sakadzic S, Devor A, Boas D, Desjardins M

Clinical and translational neurophotonics 2019

Journal Article

Proc SPIE Int Soc Opt Eng, 108640V , pp. 8 pages, 2019, ISSN: 0277-786X.

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Thunemann M, Lu Y, Liu X, Kilic K, Desjardins M, Vandenberghe M, Sadegh S, Saisan PA, Cheng Q, Weldy KL, Lyu H, Djurovic S, Andreassen OA, Dale AM, Devor A, Kuzum D

Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays.

Journal Article

Nat Commun, 9 (1), pp. 2035, 2018, ISSN: 2041-1723.

Abstract | Links:

Pouliot P, Gagnon L, Lam T, Avti PK, Bowen C, Desjardins M, Kakkar AK, Thorin E, Sakadzic S, Boas DA, Lesage F

Magnetic resonance fingerprinting based on realistic vasculature in mice.

Journal Article

Neuroimage, 149 , pp. 436-445, 2017, ISSN: 1053-8119.

Abstract | Links:

Uhlirova H, Kilic K, Tian P, Sakadzic S, Gagnon L, Thunemann M, Desjardins M, Saisan PA, Nizar K, Yaseen MA, Hagler DJ Jr, Vandenberghe M, Djurovic S, Andreassen OA, Silva GA, Masliah E, Kleinfeld D, Vinogradov S, Buxton RB, Einevoll GT, Boas DA, Dale AM, Devor A

The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.

Journal Article

Philos Trans R Soc Lond B Biol Sci, 371 (1705), 2016, ISSN: 0962-8436.

Abstract | Links:

Uhlirova H, Kilic K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadzic S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva GA, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A

Cell type specificity of neurovascular coupling in cerebral cortex.

Journal Article

Elife, 5 , 2016, ISSN: 2050-084X.

Abstract | Links:

Desjardins M, Sylvestre JP, Jafari R, Kulasekara S, Rose K, Trussart R, Arbour JD, Hudson C, Lesage F

Preliminary investigation of multispectral retinal tissue oximetry mapping using a hyperspectral retinal camera.

Journal Article

Exp Eye Res, 146 , pp. 330-40, 2016, ISSN: 0014-4835.

Abstract | Links:

Lague-Beauvais M, Fraser SA, Desjardins-Crepeau L, Castonguay N, Desjardins M, Lesage F, Bherer L

Shedding light on the effect of priority instructions during dual-task performance in younger and older adults: A fNIRS study.

Journal Article

Brain Cogn, 98 , pp. 1-14, 2015, ISSN: 0278-2626.

Abstract | Links:

18 entries « 1 of 2 »
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Active projects

  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Démarrage pour nouveau professeur - poste #64402, Subvention, Université Laval - démarrage nouveau chercheur, from 2013-11-25 to 2021-01-01
  • Développent de méthodes d'imagerie multimodale vasculaire et de l'oxygénation, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2018-04-01 to 2023-03-31
  • Mesures et modélisation de l'oxygénation dans les réseaux vasculaires tumoraux, Subvention, Fonds de recherche du Québec - Nature et technologies, Établissement de la relève professorale, from 2019-04-01 to 2021-03-31

Recently finished projects

  • Développent de méthodes d'imagerie multimodale vasculaire et de l'oxygénation, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Supplément Tremplin vers la découverte, from 2018-04-01 to 2019-03-31
  • Physiological underpinning of BOLD-fMRI signals in microstroke recovery, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2017-12-01 to 2018-11-30
Data provided by the Université Laval research projects registery