Enthused by her bachelor’s degree in Physics, Dr. Desjardins obtained her PhD in biomedical engineering from Université Pierre et Marie Curie (Paris 6) and École Polytechnique de Montréal, followed by a post-doctoral training at the University of California in San Diego. She is now an Assistant Professor in the Département de physique, de génie physique, et d’optique at Université Laval and a researcher at the Centre de Recherche du CHU de Québec-Université Laval. Her research focuses on the imaging of vasculature and oxygenation.

A window on the brain

Our cells need oxygen to function. A change in tissue oxygenation levels can thus be a sign of various pathologies. However, to this day, few methods are available to directly measure oxygenation in biological tissues. Dr. Desjardins’ research takes advantage of a newly developed technique to measure oxygenation in mouse brain using two-photon microscopy. This method allows us to observe the development of physiological or pathological phenomena with time. She also develops biophysical models describing the links between blood flow, oxygenation, and metabolism.

In her lab, these methods are used to study the link between neuronal activity, oxygenation, and blood flow in the brain. This application is made possible by combining oxygenation measurement with light stimulation of neurons in the brains of genetically-modified mice. Another application is following the development of a tumor in a mouse cancer model. By observing the evolution of tumor blood vessels and their effect on oxygenation levels, this research will improve our understanding of the mechanisms of tumor development, with the hope of guiding future therapies.

CHUL
2705, boulevard Laurier
P-09831
Québec, Québec
Canada G1V 4G2
24 entries « 1 of 3 »

Genois E, Gagnon L, Desjardins M

Modeling of vascular space occupancy and BOLD functional MRI from first principles using real microvascular angiograms.

Journal Article

Magn Reson Med, 85 (1), 2021.

Abstract | Links:

Machler P, Broggini T, Mateo C, Thunemann M, Fomin-Thunemann N, Doran PR, Sencan I, Kilic K, Desjardins M, Uhlirova H, Yaseen MA, Boas DA, Linninger AA, Vergassola M, Yu X, Lewis LD, Polimeni JR, Rosen BR, Sakadzic S, Buxton RB, Lauritzen M, Kleinfeld D, Devor A

A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI.

Journal Article

Curr Opin Biomed Eng, 18 , 2021.

Abstract | Links:

Carrier M, Guilbert J, Lévesque JP, Tremblay MÈ, Desjardins M

Structural and Functional Features of Developing Brain Capillaries, and Their Alteration in Schizophrenia.

Journal Article

Front Cell Neurosci, 14 , 2020.

Abstract | Links:

Kilic K, Desjardins M, Tang J, Thunemann M, Sunil S, Erdener SE, Postnov DD, Boas DA, Devor A

Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice.

Journal Article

Front Physiol, 11 , 2020.

Abstract | Links:

Carrier M, Robert ME, Gonzalez Ibanez F, Desjardins M, Tremblay ME

Imaging the Neuroimmune Dynamics Across Space and Time.

Journal Article

Front Neurosci, 14 , 2020.

Abstract | Links:

Sencan I, Esipova T, Kilic K, Li B, Desjardins M, Yaseen MA, Wang H, Porter JE, Kura S, Fu B, Secomb TW, Boas DA, Vinogradov SA, Devor A, Sakadzic S

Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation.

Journal Article

J Cereb Blood Flow Metab, 2020.

Abstract | Links:

Desjardins M

Causality as a New Paradigm in Brain Science.

Journal Article

Biol Psychiatry Cogn Neurosci Neuroimaging, 4 (6), 2019.

| Links:

Desjardins M, Kilic K, Thunemann M, Mateo C, Holland D, Ferri CGL, Cremonesi JA, Li B, Cheng Q, Weldy KL, Saisan PA, Kleinfeld D, Komiyama T, Liu TT, Bussell R, Wong EC, Scadeng M, Dunn AK, Boas DA, Sakadzic S, Mandeville JB, Buxton RB, Dale AM, Devor A

Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level-Dependent Functional Magnetic Resonance Imaging.

Journal Article

Biol Psychiatry Cogn Neurosci Neuroimaging, 4 (6), 2019.

Abstract | Links:

Genois E, Gagnon L, Guilbert J, Sakadzic S, Devor A, Boas D, Desjardins M

Clinical and translational neurophotonics 2019

Journal Article

Proc SPIE Int Soc Opt Eng, 108640V , 2019.

| Links:

Li B, Esipova TV, Sencan I, Kilic K, Fu B, Desjardins M, Moeini M, Kura S, Yaseen MA, Lesage F, Devor A, Boas DA, Vinogradov SA, Sakadzic S, Østergaard L

More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction.

Journal Article

Elife, 8 , 2019.

Abstract | Links:

24 entries « 1 of 3 »
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Active projects

  • Développent de méthodes d'imagerie multimodale vasculaire et de l'oxygénation, from 2018-04-01 to 2023-03-31
  • Mesures et modélisation de l'oxygénation dans les réseaux vasculaires tumoraux, from 2019-04-01 to 2022-03-31
  • Une fenêtre sur le cerveau : l'oxygénation et la perfusion comme biomarqueurs, from 2021-07-01 to 2025-06-30
  • une fenêtre sur le cerveau : l'oxygénation et la perfusion comme biomarqueurs, from 2021-07-01 to 2025-06-30

Recently finished projects

  • Microscope bi-photonique développable pour la mesure du temps de vie de, from 2019-11-01 to 2021-05-31
  • Segmentation automatique d'angiogrammes par apprentissage machine, from 2020-08-31 to 2021-03-31
Data provided by the Université Laval research projects registery