Dr. Michel Lebel PhD is a full professor in the Department of Molecular Biology, Medical Biochemistry, and Pathology at Laval University. Dr. Lebel obtained his PhD from Université de Montréal and completed post-doctoral studies in the Department of Genetics at Harvard Medical School. He has been an independent investigator since 2000 at the Centre de Recherche du CHU de Québec. His research focuses on deciphering the molecular and cellular events leading to premature aging in a mouse model of Werner syndrome. Press releases on the results of his work have been published by the Science Daily news, the National Post, Medical News Today, the Montreal Gazette, and the Nutraceuticals World online magazine. He was interviewed by the CBC radio (107,7 FM) on January 11th, 2010 and by the Journal de Québec on September 30th, 2012 (Le vieillissement, plus qu’une affaire de gènes).
Since the middle of the last century, improvements in healthcare have increased human life expectancy. However, we are now facing the new challenge and paradox of an older population with increased longevity, but often still with many years of poor health or disability ahead of them. A better understanding of the mechanisms leading to the decline in function with age would provide new predictive biomarkers and potential therapeutic targets. It is now clear that each person’s genetic code has a significant influence on the aging process. The main goal of Dr. Lebel’s research is to understand why a slight modification of certain genes precipitates the onset of age-related diseases, and to identify key biological factors leading to the onset of these diseases. In addition, using cutting-edge technologies, his team is working to understand how vitamin C and other natural products may prevent age-related diseases in humans. To do this, Dr. Lebel is studying a mouse model of a human genetic disorder called Werner syndrome, characterized by premature aging in affected patients. Finally, Dr. Lebel’s laboratory is also working to identify key proteins in the blood that would help diagnose cancer more quickly in patients.
2705, boulevard Laurier
Canada G1V 4G2
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A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2.Journal Article
Nucleic Acids Res, 47 (14), pp. 7532-7547, 2019, ISSN: 0305-1048.
Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.Journal Article
Ageing Res Rev, 41 , pp. 82-97, 2018, ISSN: 1568-1637.
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein.Journal Article
FASEB J, 32 (7), pp. 3623-3640, 2018, ISSN: 0892-6638.
Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.Journal Article
PLoS ONE, 13 (3), pp. e0193170, 2018.
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome.Journal Article
Brain Behav Immun, 73 , pp. 450-469, 2018, ISSN: 0889-1591.
Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities.Journal Article
Oncotarget, 7 (52), pp. 85680-85696, 2016, ISSN: 1949-2553.
Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.Journal Article
Aging (Albany NY), 8 (3), pp. 458-83, 2016, ISSN: 1945-4589.
Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.Journal Article
Exp Gerontol, 72 , pp. 192-203, 2015, ISSN: 0531-5565.
A 12-gene signature to distinguish colon cancer patients with better clinical outcome following treatment with 5-fluorouracil or FOLFIRI.Journal Article
The journal of pathology. Clinical research, 1 (3), pp. 160-72, 2015.
Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis.Journal Article
Biomark Med, 9 (3), pp. 187-97, 2015, ISSN: 1752-0363.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Cibler l’instabilité génomique en tant que vulnérabilité essentielle du cancer de l’ovaire, Subvention, Fonds de recherche du Québec - Santé, ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, from 2018-05-01 to 2021-04-30
Recently finished projects
- Soutien au projet de recherche en science biomédicale (endocrinologie et néphrologie)., Subvention, Fondation du CHU de Québec, from 2017-05-23 to 2019-03-31