Dr. Michel J. Tremblay is a regular researcher in the field of infectious and immune diseases at the CHU Research Center of Québec-Laval University. He is also a Professor in the Department of Microbiology-Infectiology and Immunology of the School of Medicine at Laval University, and holds the Canada Research Chair in Human Immuno-Retrovirology.

He has been Vice-Dean, Research and Graduate Studies at the Faculty of Medicine, and is currently Assistant Vice-President, Research, Creation and Innovation at Laval University. Dr. Tremblay has published over 200 articles in peer-reviewed scientific journals, and to date has received nearly $ 15 million in funding as a principal investigator and just under $ 40 million in funding as co-researcher for his research projects. Dr. Tremblay has received several awards and distinctions, including the André Dupont Award from the Clinical Research Club of Quebec and the Léo-Pariseau Award from ACFAS. Dr. Tremblay is a member of the Canadian Research Consortium on HIV Healing (CanCURE) which is funded by the Canadian Institutes of Health Research (CIHR).

His research aims to deepen our knowledge of the pathogenesis of human immunodeficiency virus (HIV) infection, the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). His research focuses on several facets of HIV infection, such as the complex interactions that occur between HIV and certain target cells of the virus (e.g., macrophages, CD4 T cells, astrocytes, etc.) and large-scale analysis of gene expression patterns following viral infection, using DNA microarrays and RNA sequencing in combination with powerful bioinformatic tools.

CHUL
2705, boulevard Laurier
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Québec, Québec
Canada G1V 4G2
197 entries « 3 of 20 »

Ouellet M, St-Pierre C, Tremblay MJ, Sato S

Effect of galectins on viral transmission.

Journal Article

Methods Mol Biol, 1207 , pp. 397-420, 2015, ISSN: 1064-3745.

Abstract | Links:

Jalaguier P, Cantin R, Maaroufi H, Tremblay MJ

Selective acquisition of host-derived ICAM-1 by HIV-1 is a matrix-dependent process.

Journal Article

J Virol, 89 (1), pp. 323-36, 2015, ISSN: 0022-538X.

Abstract | Links:

Pawlica P, Le Sage V, Poccardi N, Tremblay MJ, Mouland AJ, Berthoux L

Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.

Journal Article

J Virol, 88 (10), pp. 5661-76, 2014, ISSN: 0022-538X.

Abstract | Links:

Bertin J, Jalaguier P, Barat C, Roy MA, Tremblay MJ

Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⁺ T cells across an in vitro blood-brain barrier model.

Journal Article

Virology, 454-455 , pp. 128-38, 2014, ISSN: 0042-6822.

Abstract | Links:

Nazli A, Kafka JK, Ferreira VH, Anipindi V, Mueller K, Osborne BJ, Dizzell S, Chauvin S, Mian MF, Ouellet M, Tremblay MJ, Mossman KL, Ashkar AA, Kovacs C, Bowdish DM, Snider DP, Kaul R, Kaushic C

HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium.

Journal Article

J Immunol, 191 (8), pp. 4246-58, 2013, ISSN: 0022-1767.

Abstract | Links:

Kumar P, Lodge R, Raymond F, Ritt JF, Jalaguier P, Corbeil J, Ouellette M, Tremblay MJ

Gene expression modulation and the molecular mechanisms involved in Nelfinavir resistance in Leishmania donovani axenic amastigotes.

Journal Article

Mol Microbiol, 89 (3), pp. 565-82, 2013, ISSN: 0950-382X.

Abstract | Links:

Gobeil LA, Lodge R, Tremblay MJ

Macropinocytosis-like HIV-1 internalization in macrophages is CCR5 dependent and leads to efficient but delayed degradation in endosomal compartments.

Journal Article

J Virol, 87 (2), pp. 735-45, 2013, ISSN: 0022-538X.

Abstract | Links:

Cote SC, Plante A, Tardif MR, Tremblay MJ

Dectin-1/TLR2 and NOD2 agonists render dendritic cells susceptible to infection by X4-using HIV-1 and promote cis-infection of CD4(+) T cells.

Journal Article

PLoS ONE, 8 (7), pp. e67735, 2013.

Abstract | Links:

Lambert AA, Azzi A, Lin SX, Allaire G, St-Gelais KP, Tremblay MJ, Gilbert C

Dendritic cell immunoreceptor is a new target for anti-AIDS drug development: identification of DCIR/HIV-1 inhibitors.

Journal Article

PLoS ONE, 8 (7), pp. e67873, 2013.

Abstract | Links:

Odaka C, Loranger A, Takizawa K, Ouellet M, Tremblay MJ, Murata S, Inoko A, Inagaki M, Marceau N

Keratin 8 is required for the maintenance of architectural structure in thymus epithelium.

Journal Article

PLoS ONE, 8 (9), pp. e75101, 2013.

Abstract | Links:

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Active projects

  • Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and C04+ T-cells for HIV cure, Subvention, Instituts de recherche en santé du Canada, Subvention d'équipe : Recherche biomédicale et clinique sur le VIH/sida, from 2019-04-01 to 2024-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2024-11-06
  • Chaire du recherche du Canada en immuno-rétrovirologie humaine, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2015-01-01 to 2021-12-31

Recently finished projects

  • Development of a safe, effective and clinically acceptable VSV-based HIV vaccine, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2017-04-01 to 2020-03-31
  • Journée de la recherche de la Faculté de médecine, Subvention, Institutionnel - BDR, Fonds général de recherche du CRSNG, from 2010-11-24 to 2020-03-31
  • Possible outcomes of Leishmania co-infection on HIV-1 immunopathogenesis, latency and reactivation., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery