Dr. Michel J. Tremblay is a regular researcher in the field of infectious and immune diseases at the CHU Research Center of Québec-Laval University. He is also a Professor in the Department of Microbiology-Infectiology and Immunology of the School of Medicine at Laval University, and holds the Canada Research Chair in Human Immuno-Retrovirology.

He has been Vice-Dean, Research and Graduate Studies at the Faculty of Medicine, and is currently Assistant Vice-President, Research, Creation and Innovation at Laval University. Dr. Tremblay has published over 200 articles in peer-reviewed scientific journals, and to date has received nearly $ 15 million in funding as a principal investigator and just under $ 40 million in funding as co-researcher for his research projects. Dr. Tremblay has received several awards and distinctions, including the André Dupont Award from the Clinical Research Club of Quebec and the Léo-Pariseau Award from ACFAS. Dr. Tremblay is a member of the Canadian Research Consortium on HIV Healing (CanCURE) which is funded by the Canadian Institutes of Health Research (CIHR).

His research aims to deepen our knowledge of the pathogenesis of human immunodeficiency virus (HIV) infection, the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). His research focuses on several facets of HIV infection, such as the complex interactions that occur between HIV and certain target cells of the virus (e.g., macrophages, CD4 T cells, astrocytes, etc.) and large-scale analysis of gene expression patterns following viral infection, using DNA microarrays and RNA sequencing in combination with powerful bioinformatic tools.

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Québec, Québec
Canada G1V 4G2
197 entries « 2 of 20 »

Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen EA

Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.

Journal Article

Cell Rep, 21 (1), pp. 141-153, 2017.

Abstract | Links:

Bolduc JF, Hany L, Barat C, Ouellet M, Tremblay MJ

Epigenetic Metabolite Acetate Inhibits Class I/II Histone Deacetylases, Promotes Histone Acetylation, and Increases HIV-1 Integration in CD4+ T Cells.

Journal Article

J Virol, 91 (16), 2017, ISSN: 0022-538X.

Abstract | Links:

Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy MA, Corbeil J, Tremblay MJ

Global Mapping of the Macrophage-HIV-1 Transcriptome Reveals that Productive Infection Induces Remodeling of Host Cell DNA and Chromatin.

Journal Article

Sci Rep, 7 (1), pp. 5238, 2017, ISSN: 2045-2322.

Abstract | Links:

Bolduc JF, Ouellet M, Hany L, Tremblay MJ

Toll-Like Receptor 2 Ligation Enhances HIV-1 Replication in Activated CCR6+ CD4+ T Cells by Increasing Virus Entry and Establishing a More Permissive Environment to Infection.

Journal Article

J Virol, 91 (4), 2017, ISSN: 0022-538X.

Abstract | Links:

Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ

HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood-Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration.

Journal Article

J Immunol, 198 (3), pp. 1229-1241, 2017, ISSN: 0022-1767.

Abstract | Links:

Gomez AM, Ouellet M, Deshiere A, Breton Y, Tremblay MJ

HIV-1-Mediated BAFF Secretion in Macrophages Does Not Require Endosomal TLRs, Type-I IFN, and Nef, but Depends on the Cellular Phenotype Status.

Journal Article

J Immunol, 196 (9), pp. 3806-17, 2016, ISSN: 0022-1767.

Abstract | Links:

Sperandio S, Barat C, Cabrita MA, Gargaun A, Berezovski MV, Tremblay MJ, de Belle I

TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.

Journal Article

Proc Natl Acad Sci U S A, 112 (26), pp. E3392-401, 2015, ISSN: 0027-8424.

Abstract | Links:

Ferreira VH, Dizzell S, Nazli A, Kafka JK, Mueller K, Nguyen PV, Tremblay MJ, Cochrane A, Kaushic C

Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection.

Journal Article

J Infect Dis, 211 (11), pp. 1745-56, 2015, ISSN: 0022-1899.

Abstract | Links:

Gomez AM, Ouellet M, Tremblay MJ

HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes.

Journal Article

J Immunol, 194 (5), pp. 2300-8, 2015, ISSN: 0022-1767.

Abstract | Links:

Andreani G, Ouellet M, Menasria R, Gomez AM, Barat C, Tremblay MJ

Leishmania infantum amastigotes trigger a subpopulation of human B cells with an immunoregulatory phenotype.

Journal Article

PLoS Negl Trop Dis, 9 (2), pp. e0003543, 2015, ISSN: 1935-2727.

Abstract | Links:

197 entries « 2 of 20 »
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Active projects

  • Canadian HIV Cure Enterprise 2.0: Targeting the interplay between myeloid cells and C04+ T-cells for HIV cure, Subvention, Instituts de recherche en santé du Canada, Subvention d'équipe : Recherche biomédicale et clinique sur le VIH/sida, from 2019-04-01 to 2024-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2024-11-06
  • Chaire du recherche du Canada en immuno-rétrovirologie humaine, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2015-01-01 to 2021-12-31

Recently finished projects

  • Development of a safe, effective and clinically acceptable VSV-based HIV vaccine, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2017-04-01 to 2020-03-31
  • Journée de la recherche de la Faculté de médecine, Subvention, Institutionnel - BDR, Fonds général de recherche du CRSNG, from 2010-11-24 to 2020-03-31
  • Possible outcomes of Leishmania co-infection on HIV-1 immunopathogenesis, latency and reactivation., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery