Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.

His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.

L'Hôtel-Dieu de Québec
9, rue McMahon
0744-5
Québec, Québec
Canada G1R 2J6
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Jannot G, Boisvert ME, Banville IH, Simard MJ

Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans.

Journal Article

RNA, 14 (5), pp. 829-35, 2008, ISSN: 1355-8382.

Abstract | Links:

Hutvagner G, Simard MJ

Argonaute proteins: key players in RNA silencing.

Journal Article

Nat Rev Mol Cell Biol, 9 (1), pp. 22-32, 2008, ISSN: 1471-0072.

Abstract | Links:

Boisvert ME, Simard MJ

RNAi pathway in C. elegans: the argonautes and collaborators.

Journal Article

Curr Top Microbiol Immunol, 320 , pp. 21-36, 2008, ISSN: 0070-217X.

Abstract | Links:

Nottrott S, Simard MJ, Richter JD

Human let-7a miRNA blocks protein production on actively translating polyribosomes.

Journal Article

Nat Struct Mol Biol, 13 (12), pp. 1108-14, 2006, ISSN: 1545-9993.

Abstract | Links:

Yigit E, Batista PJ, Bei Y, Pang KM, Chen CC, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC

Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.

Journal Article

Cell, 127 (4), pp. 747-57, 2006, ISSN: 0092-8674.

Abstract | Links:

Jannot G, Simard MJ

Tumour-related microRNAs functions in Caenorhabditis elegans.

Journal Article

Oncogene, 25 (46), pp. 6197-201, 2006, ISSN: 0950-9232.

Abstract | Links:

Chen CC, Simard MJ, Tabara H, Brownell DR, McCollough JA, Mello CC

A member of the polymerase beta nucleotidyltransferase superfamily is required for RNA interference in C. elegans.

Journal Article

Curr Biol, 15 (4), pp. 378-83, 2005, ISSN: 0960-9822.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Étude de la régulation des gènes par les courts ARNs non-codants, Subvention, Fonds de recherche du Québec - Santé, Chaires de recherche FRQS, from 2017-07-01 to 2021-06-30
  • Functional dissection of the microRNA pathway., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • Genetic and molecular analysis of the siRNA-mediated gene regulation, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2019-04-01 to 2024-03-31

Recently finished projects

  • Detailed functional study of Argonaute proteins in microRNA-mediated gene regulation., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2013-10-01 to 2018-09-30
  • Genetic and molecular analysis of the siRNA-mediated silencing pathway in C. elegans., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2013-04-01 to 2019-03-31
Data provided by the Université Laval research projects registery