Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.

His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.

L'Hôtel-Dieu de Québec
9, rue McMahon
0744-5
Québec, Québec
Canada G1R 2J6
47 entries « 2 of 5 »

Zhong L, Simoneau B, Huot J, Simard MJ

p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription.

Journal Article

Oncotarget, 8 (1), pp. 1678-1687, 2017, ISSN: 1949-2553.

Abstract | Links:

Zhong L, Simoneau B, Tremblay PL, Gout S, Simard MJ, Huot J

E-selectin-mediated adhesion and extravasation in cancer

Book Chapter

M, Schwab (Ed.): Encyclopedia of Cancer, 4th edition, 2 , pp. 1618-1624, Springer-Verlag Berlin Heidelberg, 2017, ISBN: 978-3-662-46874-6 (print) / 978-3-662-46875-3 (eReference) / 978-3-662-47424-2 (Print + eBook).

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Jannot G, Michaud P, Quevillon Huberdeau M, Morel-Berryman L, Brackbill JA, Piquet S, McJunkin K, Nakanishi K, Simard MJ

GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.

Journal Article

PLoS Genet, 12 (12), pp. e1006484, 2016, ISSN: 1553-7390.

Abstract | Links:

Dallaire A, Simard MJ

The implication of microRNAs and endo-siRNAs in animal germline and early development.

Journal Article

Dev Biol, 416 (1), pp. 18-25, 2016, ISSN: 0012-1606.

Abstract | Links:

Flamand MN, Wu E, Vashisht A, Jannot G, Keiper BD, Simard MJ, Wohlschlegel J, Duchaine TF

Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans.

Journal Article

Nucleic Acids Res, 44 (12), pp. 5924-35, 2016, ISSN: 0305-1048.

Abstract | Links:

Meziane O, Piquet S, Bosse GD, Gagne D, Paquet E, Robert C, Tones MA, Simard MJ

The human decapping scavenger enzyme DcpS modulates microRNA turnover.

Journal Article

Sci Rep, 5 , pp. 16688, 2015, ISSN: 2045-2322.

Abstract | Links:

Haj-Salem I, Fakhfakh R, Berube JC, Jacques E, Plante S, Simard MJ, Bosse Y, Chakir J

MicroRNA-19a enhances proliferation of bronchial epithelial cells by targeting TGFβR2 gene in severe asthma.

Journal Article

Allergy, 70 (2), pp. 212-9, 2015, ISSN: 0105-4538.

Abstract | Links:

Dallaire A, Proulx S, Simard MJ, Lebel M

Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span.

Journal Article

BMC Genomics, 15 , pp. 940, 2014.

Abstract | Links:

Zinovyeva AY, Bouasker S, Simard MJ, Hammell CM, Ambros V

Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression.

Journal Article

PLoS Genet, 10 (4), pp. e1004286, 2014, ISSN: 1553-7390.

Abstract | Links:

Zhong L, Simoneau B, Tremblay PL, Gout S, Simard MJ, Huot J

E-selectin-mediated adhesion and extravasation in cancer (2014, 2016)

Book Chapter

M, Schwab (Ed.): Encyclopedia of Cancer (Continuously updated edition), pp. 1-7, Berlin, Springer-Verlag, 2014, ISBN: 978-3-642-27841-9 (Print) 978-3-642-27841-9 (Online) (@2016).

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Étude de la régulation des gènes par les courts ARNs non-codants, Subvention, Fonds de recherche du Québec - Santé, Chaires de recherche FRQS, from 2017-07-01 to 2021-06-30
  • Functional dissection of the microRNA pathway., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • Genetic and molecular analysis of the siRNA-mediated gene regulation, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2019-04-01 to 2024-03-31

Recently finished projects

  • Detailed functional study of Argonaute proteins in microRNA-mediated gene regulation., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2013-10-01 to 2018-09-30
  • Genetic and molecular analysis of the siRNA-mediated silencing pathway in C. elegans., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2013-04-01 to 2019-03-31
Data provided by the Université Laval research projects registery