Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.

His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.

L'Hôtel-Dieu de Québec
9, rue McMahon
0744-5
Québec, Québec
Canada G1R 2J6
+1 418-525-4444, extension 15185
+1 418-691-5439

Latest news

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Quevillon Huberdeau M, Simard MJ

A guide to microRNA-mediated gene silencing.

Journal Article

FEBS J, 286 (4), pp. 642-652, 2019, ISSN: 1742-464X.

Abstract | Links:

Dallaire A, Frederick PM, Simard MJ

Somatic and Germline MicroRNAs Form Distinct Silencing Complexes to Regulate Their Target mRNAs Differently.

Journal Article

Dev Cell, 47 (2), pp. 239-247.e4, 2018, ISSN: 1534-5807.

Abstract | Links:

Zhong L, Huot J, Simard MJ

p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells.

Journal Article

Sci Rep, 8 (1), pp. 2334, 2018, ISSN: 2045-2322.

Abstract | Links:

Fressigne L, Simard MJ

[Biogenesis of small non-coding RNAs in animals].

Journal Article

Med Sci (Paris), 34 (2), pp. 137-144, 2018, ISSN: 0767-0974.

Abstract | Links:

Zhong L, Simard MJ, Huot J

Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation.

Journal Article

FASEB J, 32 (8), pp. 4070-4084, 2018, ISSN: 0892-6638.

Abstract | Links:

Roy MA, Doiron M, Talon-Croteau J, Dupre N, Simard M

Effects of Antiparkinson Medication on Cognition in Parkinson's Disease: A Systematic Review.

Journal Article

Can J Neurol Sci, 45 (4), pp. 375-404, 2018, ISSN: 0317-1671.

Abstract | Links:

Roy-Bellavance C, Grants JM, Miard S, Lee K, Rondeau E, Guillemette C, Simard MJ, Taubert S, Picard F

The R148.3 Gene Modulates Caenorhabditis elegans Lifespan and Fat Metabolism.

Journal Article

G3 (Bethesda), 7 (8), pp. 2739-2747, 2017, ISSN: 2160-1836.

Abstract | Links:

Quevillon Huberdeau M, Zeitler DM, Hauptmann J, Bruckmann A, Fressigne L, Danner J, Piquet S, Strieder N, Engelmann JC, Jannot G, Deutzmann R, Simard MJ, Meister G

Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA-guided gene silencing in vivo.

Journal Article

EMBO J, 36 (14), pp. 2088-2106, 2017, ISSN: 0261-4189.

Abstract | Links:

Wang C, Gupta P, Fressigne L, Bosse GD, Wang X, Simard MJ, Hansen D

TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.

Journal Article

Nucleic Acids Res, 45 (3), pp. 1488-1500, 2017, ISSN: 0305-1048.

Abstract | Links:

Zhong L, Simoneau B, Huot J, Simard MJ

p38 and JNK pathways control E-selectin-dependent extravasation of colon cancer cells by modulating miR-31 transcription.

Journal Article

Oncotarget, 8 (1), pp. 1678-1687, 2017, ISSN: 1949-2553.

Abstract | Links:

46 entries « ‹ 1 of 5 › »
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Active projects

  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Étude de la régulation des gènes par les courts ARNs non-codants, Subvention, Fonds de recherche du Québec - Santé, Chaires de recherche FRQS, from 2017-07-01 to 2021-06-30
  • Functional dissection of the microRNA pathway., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • Genetic and molecular analysis of the siRNA-mediated silencing pathway in C. elegans., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2013-04-01 to 2019-03-31

Recently finished projects

  • Detailed functional study of Argonaute proteins in microRNA-mediated gene regulation., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2013-10-01 to 2018-09-30
  • Étude de la régulation des gènes par les courts ARNs non-codants., Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2014-07-01 to 2017-06-30
  • Soutien facultaire aux chercheurs seniors et nationaux., Subvention, Université Laval - démarrage nouveau chercheur, from 2014-07-01 to 2017-06-30
  • Versatile and quantitative analysis of macromolecules, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2017-03-31 to 2018-03-30
Data provided by the Université Laval research projects registery