Dr. Martin Simard, Ph.D., holds a Research Chair of the Fonds de Recherche-Santé du Québec and is professor in the Department of molecular biology, medical biochemistry, and pathology of the Laval University School of Medicine.

His research group aims to better understand how small non-coding RNAs can so efficiently control gene expression, in animals. Those molecules able to precisely control the protein production (the genes) in cells, have promptly being proposed to be implicated in different pathologies such as different types of cancers and recent scientific studies have proven their roles. The contribution of theses tiny molecules to our understanding of the cell, as well as their great potential in the detection and treatment of different diseases, makes this field of research among the most active in medical biology. His work focuses on the identification of cellular molecules that participate in the biological role of small non-coding RNAs, on understanding their roles and defining their implication in the development of different pathologies, such as cancers. At term, our studies will contribute to gather new insights about how theses tiny molecules contribute to cell function, and to develop new therapeutic strategies using the small non-coding RNAs.

L'Hôtel-Dieu de Québec
9, rue McMahon
0744-5
Québec, Québec
Canada G1R 2J6
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Shah VN, Houle F, Lavoie-Ouellet C, Mazroui R, Michaud P, Adjibade P, Quévillon Huberdeau M, Rioux R, Gu W, Simard MJ

The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.

Journal Article

PLoS Genet, 17 (4), 2021.

Abstract | Links:

Kakumani PK, Guitart T, Houle F, Harvey LM, Goyer B, Germain L, Gebauer F, Simard MJ

CSDE1 attenuates microRNA-mediated silencing of PMEPA1 in melanoma.

Journal Article

Oncogene, 40 (18), 2021.

Abstract | Links:

Kakumani PK, Harvey LM, Houle F, Guitart T, Gebauer F, Simard MJ

CSDE1 controls gene expression through the miRNA-mediated decay machinery.

Journal Article

Life Sci Alliance, 3 (4), 2020.

Abstract | Links:

Quevillon Huberdeau M, Simard MJ

A guide to microRNA-mediated gene silencing.

Journal Article

FEBS J, 286 (4), 2019.

Abstract | Links:

Pal A, Shah VN, Simard MJ

Defend Thyself and Thy Offspring.

Journal Article

Dev Cell, 50 (6), 2019.

Abstract | Links:

Zhong L, Huot J, Simard MJ

p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells.

Journal Article

Sci Rep, 8 (1), 2018.

Abstract | Links:

Fressigne L, Simard MJ

[Biogenesis of small non-coding RNAs in animals].

Journal Article

Med Sci (Paris), 34 (2), 2018.

Abstract | Links:

Dallaire A, Frederick PM, Simard MJ

Somatic and Germline MicroRNAs Form Distinct Silencing Complexes to Regulate Their Target mRNAs Differently.

Journal Article

Dev Cell, 47 (2), 2018.

Abstract | Links:

Zhong L, Simard MJ, Huot J

Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation.

Journal Article

FASEB J, 32 (8), 2018.

Abstract | Links:

Zhong L, Simoneau B, Tremblay PL, Gout S, Simard MJ, Huot J

E-selectin-mediated adhesion and extravasation in cancer

Book Chapter

M, Schwab (Ed.): Encyclopedia of Cancer, 4th edition, 2 , pp. 1618-1624, Springer-Verlag Berlin Heidelberg, 2017, ISBN: 9783662468746.

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Active projects

  • Acquisition d'un appareil PCR pour analyses d'échantillons biologiques , from 2021-07-16 to 2022-07-15
  • Canadian Developmental Biology Conference 2023, from 2021-04-01 to 2023-03-31
  • Genetic and molecular analysis of the siRNA-mediated gene regulation, from 2019-04-01 to 2024-03-31
  • Understanding the regulation and implication of Argonaute in microRNA-mediated gene silencing., from 2020-10-01 to 2025-09-30

Recently finished projects

  • (FRSQ 91332) Acquisition d'un homogénéiseur à haut débit, from 2019-07-23 to 2020-03-31
  • Étude de la régulation des gènes par les courts ARNs non-codants, from 2017-07-01 to 2021-06-30
  • Functional dissection of the microRNA pathway., from 2015-07-01 to 2021-03-31
Data provided by the Université Laval research projects registery