Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

106 entries « 9 of 11 »

Sierra A, Tremblay ME, Wake H

Never-resting microglia: physiological roles in the healthy brain and pathological implications.

Journal Article

Front Cell Neurosci, 8 , pp. 240, 2014.

| Links:

Paolicelli RC, Bisht K, Tremblay ME

Fractalkine regulation of microglial physiology and consequences on the brain and behavior.

Journal Article

Front Cell Neurosci, 8 , pp. 129, 2014.

Abstract | Links:

Tremblay ME, Sierra A

Introduction

Book Chapter

ME, Tremblay; A, Sierra (Ed.): Microglia in Health and Disease, pp. 3-6, New York, Springer, 2014, ISBN: 978-1493914289.

| Links:

Tremblay ME, Paolicelli RC, Stevens B, Wake H, Bessis A

Developing and mature synapses

Book Chapter

ME, Tremblay; A, Sierra (Ed.): Microglia in Health and Disease, pp. 223-248, New York, Springer, 2014, ISBN: 978-1493914289.

| Links:

Sierra A, Tremblay ME

Adult Neurogenesis, Learning and Memory

Book Chapter

ME, Tremblay; A, Sierra (Ed.): Microglia in Health and Disease, pp. 249-272, New York, Springer, 2014, ISBN: 978-1493914289.

| Links:

Tremblay ME, Sierra A

Microglia in Health and Disease

Book

Springer, New York, 2014, ISBN: 978-1493914289.

| Links:

Tremblay ME, Marker DF, Puccini JM, Muly EC, Lu SM, Gelbard HA

Ultrastructure of microglia-synapse interactions in the HIV-1 Tat-injected murine central nervous system.

Journal Article

Commun Integr Biol, 6 (6), pp. e27670, 2013.

Abstract | Links:

Kelly EA, Tremblay ME, Gahmberg CG, Tian L, Majewska AK

Interactions between intercellular adhesion molecule-5 positive elements and their surroundings in the rodent visual cortex.

Journal Article

Commun Integr Biol, 6 (6), pp. e27315, 2013.

Abstract | Links:

Marker DF, Tremblay ME, Puccini JM, Barbieri J, Gantz Marker MA, Loweth CJ, Muly EC, Lu SM, Goodfellow VS, Dewhurst S, Gelbard HA

The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.

Journal Article

J Neurosci, 33 (24), pp. 9998-10010, 2013, ISSN: 0270-6474.

Abstract | Links:

Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE

DCC expression by neurons regulates synaptic plasticity in the adult brain.

Journal Article

Cell Rep, 3 (1), pp. 173-85, 2013.

Abstract | Links:

106 entries « 9 of 11 »
Signaler des ajouts ou des modifications