Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

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Bellver-Landete V, Bretheau F, Mailhot B, Vallieres N, Lessard M, Janelle ME, Vernoux N, Tremblay ME, Fuehrmann T, Shoichet MS, Lacroix S

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.

Journal Article

Nat Commun, 10 (1), pp. 518, 2019, ISSN: 2041-1723.

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Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, Tremblay ME, Vincent AT, Gould PV, Chouinard S, Weyrich AS, Rondina MT, Barker RA, Boilard E, Cicchetti F

Platelet abnormalities in Huntington's disease.

Journal Article

J Neurol Neurosurg Psychiatry, 90 (3), pp. 272-283, 2019, ISSN: 0022-3050.

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Nichols MR, St-Pierre MK, Wendeln AC, Makoni NJ, Gouwens LK, Garrad EC, Sohrabi M, Neher JJ, Tremblay ME, Combs CK

Inflammatory mechanisms in neurodegeneration.

Journal Article

J Neurochem, 149 (5), pp. 562-581, 2019, ISSN: 0022-3042.

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Savage JC, Tremblay ME

Studying Laboratory Mice - Into the Wild.

Journal Article

Trends Neurosci, 42 (9), pp. 566-568, 2019, ISSN: 0166-2236.

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Bordeleau M, Carrier M, Luheshi GN, Tremblay ME

Microglia along sex lines: From brain colonization, maturation and function, to implication in neurodevelopmental disorders.

Journal Article

Semin Cell Dev Biol, 94 , pp. 152-163, 2019, ISSN: 1084-9521.

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St-Pierre MK, Bordeleau M, Tremblay ME

Visualizing Dark Microglia.

Journal Article

Methods Mol Biol, 2034 , pp. 97-110, 2019, ISSN: 1064-3745.

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Tremblay ME, Majewska AK

Ultrastructural Analyses of Microglial Interactions with Synapses.

Journal Article

Methods Mol Biol, 2034 , pp. 83-95, 2019, ISSN: 1064-3745.

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Savage JC, Carrier M, Tremblay ME

Morphology of Microglia Across Contexts of Health and Disease.

Journal Article

Methods Mol Biol, 2034 , pp. 13-26, 2019, ISSN: 1064-3745.

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Tay TL, Carrier M, Tremblay ME

Physiology of Microglia.

Journal Article

Adv Exp Med Biol, 1175 , pp. 129-148, 2019, ISSN: 0065-2598.

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Savage JC, St-Pierre MK, Hui CW, Tremblay ME

Microglial Ultrastructure in the Hippocampus of a Lipopolysaccharide-Induced Sickness Mouse Model.

Journal Article

Front Neurosci, 13 , pp. 1340, 2019, ISSN: 1662-4548.

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