Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

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St-Pierre MK, Simoncicova E, Bogi E, Tremblay ME

Shedding Light on the Dark Side of the Microglia.

Journal Article

ASN Neuro, 12 , pp. 1759091420925335, 2020, ISSN: 1759-0914.

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Ouellette J, Toussay X, Comin CH, Costa LDF, Ho M, Lacalle-Aurioles M, Freitas-Andrade M, Liu QY, Leclerc S, Pan Y, Liu Z, Thibodeau JF, Yin M, Carrier M, Morse CJ, Dyken PV, Bergin CJ, Baillet S, Kennedy CR, Tremblay ME, Benoit YD, Stanford WL, Burger D, Stewart DJ, Lacoste B

Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice.

Journal Article

Nat Neurosci, 23 (9), pp. 1090-1101, 2020, ISSN: 1097-6256.

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Lecours C, St-Pierre MK, Picard K, Bordeleau M, Bourque M, Oluleke Awogbindin I, Benadjal A, Gonzalez Ibanez F, Gagnon D, Cantin L, Parent M, Di Paolo T, Tremblay ME

Levodopa partially rescues microglial numerical, morphological, and phagolysosomal alterations in a monkey model of Parkinson's disease.

Journal Article

Brain Behav Immun, 90 , pp. 81-96, 2020, ISSN: 0889-1591.

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Carrier M, Robert ME, Gonzalez Ibanez F, Desjardins M, Tremblay ME

Imaging the Neuroimmune Dynamics Across Space and Time.

Journal Article

Front Neurosci, 14 , pp. 903, 2020, ISSN: 1662-4548.

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Francavilla R, Guet-McCreight A, Amalyan S, Hui CW, Topolnik D, Michaud F, Marino B, Tremblay ME, Skinner FK, Topolnik L

Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 VIP Interneurons During Aging.

Journal Article

Front Cell Neurosci, 14 , pp. 554405, 2020.

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Hui CW, Vecchiarelli HA, Gervais E, Luo X, Michaud F, Scheefhals L, Bisht K, Sharma K, Topolnik L, Tremblay ME

Sex Differences of Microglia and Synapses in the Hippocampal Dentate Gyrus of Adult Mouse Offspring Exposed to Maternal Immune Activation.

Journal Article

Front Cell Neurosci, 14 , pp. 558181, 2020.

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Tremblay ME, Madore C, Bordeleau M, Tian L, Verkhratsky A

Neuropathobiology of COVID-19: The Role for Glia.

Journal Article

Front Cell Neurosci, 14 , pp. 592214, 2020.

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Subramanian J, Savage JC, Tremblay ME

Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models.

Journal Article

Front Cell Neurosci, 14 , pp. 592607, 2020.

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Tremblay ME

A Diversity of Cell Types, Subtypes and Phenotypes in the Central Nervous System: The Importance of Studying Their Complex Relationships.

Journal Article

Front Cell Neurosci, 14 , pp. 628347, 2020.

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Gonzalez Ibanez F, Picard K, Bordelau M, Sharma K, Bisht K, Tremblay ME

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain.

Journal Article

J Vis Exp, (152), 2019.

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