Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

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Stratoulias V, Venero JL, Tremblay ME, Joseph B

Microglial subtypes: diversity within the microglial community.

Journal Article

EMBO J, 38 (17), pp. e101997, 2019, ISSN: 0261-4189.

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Jean LeBlanc N, Menet R, Picard K, Parent G, Tremblay ME, ElAli A

Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy.

Journal Article

Mol Neurobiol, 56 (9), pp. 6521-6538, 2019, ISSN: 0893-7648.

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Lounas A, Vernoux N, Germain M, Tremblay ME, Richard FJ

Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells.

Journal Article

Sci Rep, 9 (1), pp. 12493, 2019, ISSN: 2045-2322.

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Mallard C, Tremblay ME, Vexler ZS

Microglia and Neonatal Brain Injury.

Journal Article

Neuroscience, 405 , pp. 68-76, 2019, ISSN: 0306-4522.

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El Hajj H, Savage JC, Bisht K, Parent M, Vallieres L, Rivest S, Tremblay ME

Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology.

Journal Article

J Neuroinflammation, 16 (1), pp. 87, 2019.

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Tremblay ME, Cookson MR, Civiero L

Glial phagocytic clearance in Parkinson's disease.

Journal Article

Mol Neurodegener, 14 (1), pp. 16, 2019.

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Becker Y, Loignon RC, Julien AS, Marcoux G, Allaeys I, Levesque T, Rollet-Labelle E, Benk-Fortin H, Cloutier N, Melki I, Eder L, Wagner E, Pelletier M, Hajj HE, Tremblay ME, Belleannee C, Hebert MJ, Dieude M, Rauch J, Fortin PR, Boilard E

Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations.

Journal Article

Sci Rep, 9 (1), pp. 4530, 2019, ISSN: 2045-2322.

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Hui CW, Bhardwaj SK, Sharma K, Joseph AT, Bisht K, Picard K, Tremblay ME, Srivastava LK

Microglia in the developing prefrontal cortex of rats show dynamic changes following neonatal disconnection of the ventral hippocampus.

Journal Article

Neuropharmacology, 146 , pp. 264-275, 2019, ISSN: 0028-3908.

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Bellver-Landete V, Bretheau F, Mailhot B, Vallieres N, Lessard M, Janelle ME, Vernoux N, Tremblay ME, Fuehrmann T, Shoichet MS, Lacroix S

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.

Journal Article

Nat Commun, 10 (1), pp. 518, 2019, ISSN: 2041-1723.

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Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, Tremblay ME, Vincent AT, Gould PV, Chouinard S, Weyrich AS, Rondina MT, Barker RA, Boilard E, Cicchetti F

Platelet abnormalities in Huntington's disease.

Journal Article

J Neurol Neurosurg Psychiatry, 90 (3), pp. 272-283, 2019, ISSN: 0022-3050.

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