Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

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Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE

DCC expression by neurons regulates synaptic plasticity in the adult brain.

Journal Article

Cell Rep, 3 (1), pp. 173-85, 2013.

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Siskova Z, Tremblay ME

Microglia and synapse: interactions in health and neurodegeneration.

Journal Article

Neural Plast, 2013 , pp. 425845, 2013.

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Tremblay ME, Zettel ML, Ison JR, Allen PD, Majewska AK

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices.

Journal Article

Glia, 60 (4), pp. 541-58, 2012, ISSN: 0894-1491.

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Tremblay ME, Stevens B, Sierra A, Wake H, Bessis A, Nimmerjahn A

The role of microglia in the healthy brain.

Journal Article

J Neurosci, 31 (45), pp. 16064-9, 2011, ISSN: 0270-6474.

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Tremblay ME, Majewska AK

A role for microglia in synaptic plasticity?

Journal Article

Commun Integr Biol, 4 (2), pp. 220-2, 2011.

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Tremblay ME

The role of microglia at synapses in the healthy CNS: novel insights from recent imaging studies.

Journal Article

Neuron Glia Biol, 7 (1), pp. 67-76, 2011, ISSN: 1740-925X.

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Lu SM, Tremblay ME, King IL, Qi J, Reynolds HM, Marker DF, Varrone JJ, Majewska AK, Dewhurst S, Gelbard HA

HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells.

Journal Article

PLoS ONE, 6 (9), pp. e23915, 2011.

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Kelly EA, Tremblay ME, McCasland JS, Majewska AK

Postsynaptic deregulation in GAP-43 heterozygous mouse barrel cortex.

Journal Article

Cereb Cortex, 20 (7), pp. 1696-707, 2010, ISSN: 1047-3211.

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Bouvier D, Tremblay ME, Riad M, Corera AT, Gingras D, Horn KE, Fotouhi M, Girard M, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G

EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain.

Journal Article

J Neurochem, 113 (1), pp. 153-65, 2010, ISSN: 0022-3042.

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Tremblay ME, Riad M, Majewska A

Preparation of mouse brain tissue for immunoelectron microscopy.

Journal Article

J Vis Exp, 41 (41), pp. e2021, 2010.

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107 entries « 10 of 11 »
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