Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.


+1 250-721-8739
evetremblay@uvic.ca

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Awogbindin IO, Ishola IO, St-Pierre MK, Carrier M, Savage JC, Di Paolo T, Tremblay ME

Remodeling microglia to a protective phenotype in Parkinson's disease?

Journal Article

Neurosci Lett, 735 , pp. 135164, 2020, ISSN: 0304-3940.

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Gratuze M, Leyns CE, Sauerbeck AD, St-Pierre MK, Xiong M, Kim N, Remolina Serrano J, Tremblay ME, Kummer TT, Colonna M, Ulrich JD, Holtzman DM

Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.

Journal Article

J Clin Invest, 130 (9), pp. 4954-4968, 2020, ISSN: 0021-9738.

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Ouellette J, Toussay X, Comin CH, Costa LDF, Ho M, Lacalle-Aurioles M, Freitas-Andrade M, Liu QY, Leclerc S, Pan Y, Liu Z, Thibodeau JF, Yin M, Carrier M, Morse CJ, Dyken PV, Bergin CJ, Baillet S, Kennedy CR, Tremblay ME, Benoit YD, Stanford WL, Burger D, Stewart DJ, Lacoste B

Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice.

Journal Article

Nat Neurosci, 23 (9), pp. 1090-1101, 2020, ISSN: 1097-6256.

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Lecours C, St-Pierre MK, Picard K, Bordeleau M, Bourque M, Oluleke Awogbindin I, Benadjal A, Gonzalez Ibanez F, Gagnon D, Cantin L, Parent M, Di Paolo T, Tremblay ME

Levodopa partially rescues microglial numerical, morphological, and phagolysosomal alterations in a monkey model of Parkinson's disease.

Journal Article

Brain Behav Immun, 2020, ISSN: 0889-1591.

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Matovic S, Ichiyama A, Igarashi H, Salter EW, Sunstrum JK, Wang XF, Henry M, Kuebler ES, Vernoux N, Martinez-Trujillo J, Tremblay ME, Inoue W

Neuronal hypertrophy dampens neuronal intrinsic excitability and stress responsiveness during chronic stress.

Journal Article

J Physiol, 598 (13), pp. 2757-2773, 2020, ISSN: 0022-3751.

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Sharma K, Tremblay ME

Microglia: Multiple states and multiple roles in the normal and diseased brain and spinal cord.

Journal Article

Neurosci Lett, 729 , pp. 135019, 2020, ISSN: 0304-3940.

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Savage JC, St-Pierre MK, Carrier M, El Hajj H, Novak SW, Sanchez MG, Cicchetti F, Tremblay ME

Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington's disease pathology.

Journal Article

J Neuroinflammation, 17 (1), pp. 98, 2020.

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Garofalo S, Picard K, Limatola C, Nadjar A, Pascual O, Tremblay ME

Role of Glia in the Regulation of Sleep in Health and Disease.

Journal Article

Compr Physiol, 10 (2), pp. 687-712, 2020, ISSN: 2040-4603.

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Tian W, Alsaadi R, Guo Z, Kalinina A, Carrier M, Tremblay ME, Lacoste B, Lagace D, Russell RC

An antibody for analysis of autophagy induction.

Journal Article

Nat Methods, 17 (2), pp. 232-239, 2020, ISSN: 1548-7091.

Abstract | Links:

St-Pierre MK, Simoncicova E, Bogi E, Tremblay ME

Shedding Light on the Dark Side of the Microglia.

Journal Article

ASN Neuro, 12 , pp. 1759091420925335, 2020, ISSN: 1759-0914.

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