Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.


+1 250-721-8739
evetremblay@uvic.ca

Latest news

128 entries « ‹ 1 of 13 › »

Bordeleau M, Fernández de Cossío L, Lacabanne C, Savage JC, Vernoux N, Chakravarty M, Tremblay MÈ

Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring.

Journal Article

Brain Behav Immun Health, 15 , 2021.

Abstract | Links:

Tremblay MÈ

Microglial functional alteration and increased diversity in the challenged brain: Insights into novel targets for intervention.

Journal Article

Brain Behav Immun Health, 16 , 2021.

Abstract | Links:

De Meij J, Alfanek Z, Morel L, Decoeur F, Leyrolle Q, Picard K, Carrier M, Aubert A, Séré A, Lucas C, Laforest G, Helbling JC, Tremblay ME, Cota D, Moisan MP, Marsicano G, Layé S, Nadjar A

Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner.

Journal Article

Cannabis Cannabinoid Res, 2021.

Abstract | Links:

Augusto-Oliveira M, Arrifano GP, Delage CI, Tremblay MÈ, Crespo-Lopez ME, Verkhratsky A

Plasticity of microglia.

Journal Article

Biol Rev Camb Philos Soc, 2021.

Abstract | Links:

Leyrolle Q, Decoeur F, Dejean C, Brière G, Leon S, Bakoyiannis I, Baroux E, Sterley TL, Bosch-Bouju C, Morel L, Amadieu C, Lecours C, St-Pierre MK, Bordeleau M, De Smedt-Peyrusse V, Séré A, Schwendimann L, Grégoire S, Bretillon L, Acar N, Joffre C, Ferreira G, Uricaru R, Thebault P, Gressens P, Tremblay ME, Layé S, Nadjar A

N-3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development.

Journal Article

Glia, 2021.

Abstract | Links:

Corsi G, Picard K, di Castro MA, Garofalo S, Tucci F, Chece G, Del Percio C, Golia MT, Raspa M, Scavizzi F, Decoeur F, Lauro C, Rigamonti M, Iannello F, Ragozzino DA, Russo E, Bernardini G, Nadjar A, Tremblay ME, Babiloni C, Maggi L, Limatola C

Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle.

Journal Article

Glia, 2021.

Abstract | Links:

Bisht K, Okojie KA, Sharma K, Lentferink DH, Sun YY, Chen HR, Uweru JO, Amancherla S, Calcuttawala Z, Campos-Salazar AB, Corliss B, Jabbour L, Benderoth J, Friestad B, Isakson BE, Tremblay MÈ, Kuan CY, Eyo UB, Mills WA

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice.

Journal Article

Nat Commun, 12 (1), 2021.

Abstract | Links:

Awogbindin IO, Ben-Azu B, Olusola BA, Akinluyi ET, Adeniyi PA, Di Paolo T, Tremblay MÈ

Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson's Disease.

Journal Article

Front Cell Neurosci, 15 , 2021.

Abstract | Links:

Picard K, Bisht K, Poggini S, Garofalo S, Golia MT, Basilico B, Abdallah F, Ciano Albanese N, Amrein I, Vernoux N, Sharma K, Hui CW, C Savage J, Limatola C, Ragozzino D, Maggi L, Branchi I, Tremblay MÈ

Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice.

Journal Article

Brain Behav Immun, 97 , 2021.

Abstract | Links:

Fernández de Cossío L, Lacabanne C, Bordeleau M, Castino G, Kyriakakis P, Tremblay MÈ

Lipopolysaccharide-induced maternal immune activation modulates microglial CX3CR1 protein expression and morphological phenotype in the hippocampus and dentate gyrus, resulting in cognitive inflexibility during late adolescence.

Journal Article

Brain Behav Immun, 97 , 2021.

Abstract | Links:

128 entries « ‹ 1 of 13 › »
Signaler des ajouts ou des modifications

Active projects

  • MICROGLIA-SYNAPSE INTERACTIONS: THEIR ROLES IN THE BRAIN’S ADAPTATION TO ENVIRONMENTAL CHALLENGES., from 2014-04-01 to 2022-03-31
  • Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth, from 2019-03-18 to 2024-03-17

Recently finished projects

  • 3rd Neuroforum of the CHU de Québec - Université Laval Research Center: A seminar series of le2aders in neuroscience, from 2020-01-01 to 2020-03-31
  • Chaire de recherche du Canada en plasticité neuroimmunitaire en santé et thérapie, from 2017-07-01 to 2020-03-31
  • Chaire de recherche du Canada en plasticité neuroimmunitaire en santé et thérapie, from 2019-01-11 to 2020-03-31
  • Mechanisms of therapeutic efficacy of deep brain stimulation in Parkinson's disease, from 2015-07-01 to 2020-06-30
  • Microglial control of synaptic function in stress response and vulnerability to depression, from 2018-05-15 to 2021-05-14
  • Rho-kinase2 inhibition as an early intervention after ischemic stroke to modulate cerebrovascular plasticity and promote functional recovery, from 2017-04-01 to 2020-03-31
  • Role of developing hippocampus in organizing prefrontal cortical functions, from 2015-07-01 to 2021-03-31
  • Targeting microglia-synapse interactions to rescue brain circuits elimination and cognitive dysfunction, from 2016-07-01 to 2020-03-31
Data provided by the Université Laval research projects registery