Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

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Bordeleau M, Carrier M, Luheshi GN, Tremblay ME

Microglia along sex lines: From brain colonization, maturation and function, to implication in neurodevelopmental disorders.

Journal Article

Semin Cell Dev Biol, 94 , pp. 152-163, 2019, ISSN: 1084-9521.

Abstract | Links:

Stratoulias V, Venero JL, Tremblay ME, Joseph B

Microglial subtypes: diversity within the microglial community.

Journal Article

EMBO J, 38 (17), pp. e101997, 2019, ISSN: 0261-4189.

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Jean LeBlanc N, Menet R, Picard K, Parent G, Tremblay ME, ElAli A

Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy.

Journal Article

Mol Neurobiol, 56 (9), pp. 6521-6538, 2019, ISSN: 0893-7648.

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Savage JC, Tremblay ME

Studying Laboratory Mice - Into the Wild.

Journal Article

Trends Neurosci, 42 (9), pp. 566-568, 2019, ISSN: 0166-2236.

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Lounas A, Vernoux N, Germain M, Tremblay ME, Richard FJ

Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells.

Journal Article

Sci Rep, 9 (1), pp. 12493, 2019, ISSN: 2045-2322.

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Nichols MR, St-Pierre MK, Wendeln AC, Makoni NJ, Gouwens LK, Garrad EC, Sohrabi M, Neher JJ, Tremblay ME, Combs CK

Inflammatory mechanisms in neurodegeneration.

Journal Article

J Neurochem, 149 (5), pp. 562-581, 2019, ISSN: 0022-3042.

Abstract | Links:

Mallard C, Tremblay ME, Vexler ZS

Microglia and Neonatal Brain Injury.

Journal Article

Neuroscience, 405 , pp. 68-76, 2019, ISSN: 0306-4522.

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El Hajj H, Savage JC, Bisht K, Parent M, Vallieres L, Rivest S, Tremblay ME

Ultrastructural evidence of microglial heterogeneity in Alzheimer's disease amyloid pathology.

Journal Article

J Neuroinflammation, 16 (1), pp. 87, 2019.

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Tremblay ME, Cookson MR, Civiero L

Glial phagocytic clearance in Parkinson's disease.

Journal Article

Mol Neurodegener, 14 (1), pp. 16, 2019.

Abstract | Links:

Becker Y, Loignon RC, Julien AS, Marcoux G, Allaeys I, Levesque T, Rollet-Labelle E, Benk-Fortin H, Cloutier N, Melki I, Eder L, Wagner E, Pelletier M, Hajj HE, Tremblay ME, Belleannee C, Hebert MJ, Dieude M, Rauch J, Fortin PR, Boilard E

Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations.

Journal Article

Sci Rep, 9 (1), pp. 4530, 2019, ISSN: 2045-2322.

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86 entries « 1 of 9 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
  • Chaire de recherche du Canada en plasticité neuroimmunitaire en santé et thérapie, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Allocation de recherche pour les Chaires de recherche du Canada Niveau 2 aux premiers termes, from 2019-01-11 to 2022-11-30
  • Chaire de recherche du Canada en plasticité neuroimmunitaire en santé et thérapie, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-07-01 to 2022-11-30
  • Mechanisms of therapeutic efficacy of deep brain stimulation in Parkinson's disease, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • MICROGLIA-SYNAPSE INTERACTIONS: THEIR ROLES IN THE BRAIN’S ADAPTATION TO ENVIRONMENTAL CHALLENGES., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2014-04-01 to 2020-03-31
  • Microglial control of synaptic function in stress response and vulnerability to depression, Subvention, Fonds de recherche du Québec - Santé, Appel à projets dans le cadre de l'ERA-NET NEURON, from 2018-05-15 to 2021-05-14
  • Rho-kinase2 inhibition as an early intervention after ischemic stroke to modulate cerebrovascular plasticity and promote functional recovery, Subvention, Fondation des maladies du coeur et de l'AVC du Canada, Subventions de recherche, from 2017-04-01 to 2020-03-31
  • Role of developing hippocampus in organizing prefrontal cortical functions, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • Targeting microglia-synapse interactions to rescue brain circuits elimination and cognitive dysfunction, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2016-07-01 to 2021-06-30

Recently finished projects

  • Le rôle des microglies dans le remodelage de la circuiterie neuronale en conditions de santé et de maladie neurodégénérative., Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2015-07-01 to 2019-06-30
  • Le rôle des microglies dans le remodelage de la circuiterie neuronale en conditions de santé et de maladie neurodégénérative., Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2015-07-01 to 2018-06-30
Data provided by the Université Laval research projects registery