Dr. Marie-Ève Tremblay is a Canada Research Chair (Tier 2) in Neuroimmunity Plasticity in Health and Therapy, researcher within the Neurosciences Axis of the CRCHU de Quebec-Laval University, and Assistant Professor in Laval University’s Department of Molecular Medicine since March of 2013.

Dr. Tremblay is a neuroimmunology specialist who uses state-of-the-art techniques in electron microscopy (with immunostaining and 3D reconstruction) and non-invasive two-photon in vivo imaging, in combination with animal behaviour, as well as cellular and molecular biology. Her discovery that microglia, the immune cells of the brain, actively remodel the neuronal circuitry under normal physiological conditions, has led to the development of a new field of research, investigating their roles in the healthy brain. Through her many initiatives on the national and international scenes, Dr. Tremblay contributes to the development of this emergent field of research which is currently experiencing an explosive growth.

Dr. Tremblay’s work and other recent studies have demonstrated that microglia play a critical role in the remodelling of the neuronal circuits required for learning, memory, and other complex cognitive functions throughout the lifespan. In this context, her laboratory at CRCHU de Québec-Laval University studies the involvement of microglia in the loss of synapses, which is the best neuropathological correlate of cognitive decline across chronic stress, major depression, schizophrenia, aging, and neurodegenerative diseases including Alzheimer’s, the most prevalent in Canada and worldwide. Chronic stress is well known for triggering depression, accelerating cognitive aging, predisposing to neuropsychiatric and neurodegenerative diseases, as well as exacerbating their progression and symptoms.

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Latest news

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Bisht K, Sharma K, Tremblay ME

Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress.

Journal Article

Neurobiol Stress, 9 , pp. 9-21, 2018, ISSN: 2352-2895.

Abstract | Links:

Acharjee S, Verbeek M, Daniel Gomez C, Bisht K, Lee B, Benoit L, Sharkey KA, Benediktsson A, Tremblay ME, Pittman QJ

Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity.

Journal Article

J Neurosci, 38 (42), pp. 9019-9033, 2018, ISSN: 0270-6474.

Abstract | Links:

Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, Tremblay ME, Gould P, Rosser AE, Dunnett SB, Piccini P, Barker RA, Cicchetti F

Outcome of cell suspension allografts in a patient with Huntington's disease.

Journal Article

Ann Neurol, 2018, ISSN: 0364-5134.

Abstract | Links:

Hui CW, St-Pierre MK, Detuncq J, Aumailley L, Dubois MJ, Couture V, Skuk D, Marette A, Tremblay JP, Lebel M, Tremblay ME

Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome.

Journal Article

Brain Behav Immun, 73 , pp. 450-469, 2018, ISSN: 0889-1591.

Abstract | Links:

Bernet A, Bastien A, Soulet D, Jerczynski O, Roy C, Bianchi Rodrigues Alves M, Lecours C, Tremblay ME, Bailey JL, Robert C, Belleannee C

Cell-lineage specificity of primary cilia during postnatal epididymal development.

Journal Article

Hum Reprod, 33 (10), pp. 1829-1838, 2018, ISSN: 0268-1161.

Abstract | Links:

70 entries « ‹ 1 of 14 › »

Active projects

  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
  • Chaire de recherche du Canada en plasticité neuroimmunitaire en santé et thérapie, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-07-01 to 2022-11-30
  • Le rôle des microglies dans le remodelage de la circuiterie neuronale en conditions de santé et de maladie neurodégénérative., Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2015-07-01 to 2019-06-30
  • Mechanisms of therapeutic efficacy of deep brain stimulation in Parkinson's disease, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • MICROGLIA-SYNAPSE INTERACTIONS: THEIR ROLES IN THE BRAIN’S ADAPTATION TO ENVIRONMENTAL CHALLENGES., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2014-04-01 to 2020-03-31
  • Rho-kinase2 inhibition as an early intervention after ischemic stroke to modulate cerebrovascular plasticity and promote functional recovery, Subvention, Fondation des maladies du coeur et de l'AVC du Canada, Subventions de recherche, from 2017-04-01 to 2020-03-31
  • Role of developing hippocampus in organizing prefrontal cortical functions., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • Targeting microglia-synapse interactions to rescue brain circuits elimination and cognitive dysfunction, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2016-07-01 to 2021-06-30

Recently finished projects

  • Impact d'une carence en Omega-3 sur le développement cérébral dépendant de la microglie, Subvention, Fonds de recherche du Québec - Nature et technologies, Programme de développement de partenariats stratégiques en matière d’enseignement et de recherche, from 2016-04-01 to 2018-03-31
  • Laboratory of neuroimmune intercellular dynamics in the healthy and diseased brain, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2014-09-01 to 2017-03-31
  • Le rôle des microglies dans le remodelage de la circuiterie neuronale en conditions de santé et de maladie neurodégénérative., Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2015-07-01 to 2018-06-30
  • Microglia-synapse interactions : the bridge between neuroinflammation and neurodevelopmental disorders, Subvention, National Alliance for Research on Schizophrenia and Depression, Young Investigator Grant, from 2016-01-15 to 2018-01-14
  • Transition from acute to chronic neuroinflammation, Subvention, Instituts de recherche en santé du Canada, Subvention d'équipe : Neuroinflammation, from 2015-02-01 to 2018-01-31
Data provided by the Université Laval research projects registery