Dr. Marc Pouliot is a Full Professor in the Department of Microbiology-Infectious Diseases and Immunology, of the Laval University School of Medicine, leading a knowledge development program on the implication of neutrophils in inflammatory responses. After completing his Ph.D in 1994 in molecular biology at Laval University, under the supervision of Dr. Pierre-Borgeat, Dr. Pouliot specialized in immunology during two postdoctoral fellowships, at the Royal Adelaide Hospital (South Australia), and then at the Brigham and Women’s Hospital (Harvard Medical School, Boston, USA), he joined in 2000 (Full professor since 2009). He was awarded competitive scholarships, continuously from Master’s degree to Senior Investigator level, from: Fonds canadien pour l’avancement de la recherche (Masters); Fonds de la Recherche en Santé du Québec (Ph.D.); Medical Research Council (Post-doc, and Centennial Distinguished Post-doc awards); Canadian Pain Society, Banting Research Foundation, CAN, TAS and CIHR (New Investigator & Investigator); and from FRSQ (Junior & Senior Investigator). As PI, he has been funded by the Canadian Institutes of Health Research (CIHR) for the last 17 years, and by The Arthritis Society (TAS), the Canadian Arthritis Network (CAN; a National Center of Excellence), the National Institutes of Health (US), and the Canadian Foundation for Innovation (CFI). Some career numbers: Peer-reviewed publications: 53, Book chapters: 5, h index: 25 (2394 citations, 882 since 2012), i10 index: 33 (Google Scholar), Funding (as PI): >2M$. He has supervised 4 post-docs, 30 graduate students and trainees, and has reviewed more than 45 Ph.D. theses and Master’s memoirs.
Adenosine & neutrophils
Dr. Pouliot’s research program focusses on extricating the full worth of neutrophils in innate immunity. He and his team have contributed to show that neutrophils can produce a tightly regulated array of mediators, including eicosanoids, cytokines, and chemokines, that can influence each of the phases of an inflammatory response. His team showed that engagement of the adenosine A2A receptor represents a master key in re-programming neutrophils, on one hand by shifting their leukotriene B4-generating capacity toward prostaglandin E2 instead, and on the other hand, by preventing the generation of inflammatory cytokines, including TNF. How A2A receptor engagement can favour the resolution phase of inflammation through its actions on neutrophils has raised considerable interest, exemplified by invited oral presentations during: the 6th World Congress on Inflammation (WCI, Vancouver), at the 8th WCI (Copenhagen), the Purines Congress (Copenhagen), the opening session of the Banff Inflammation Workshop, the 9th WCI (Tokyo), the joint SLB and Neutrophil 2016 in Verona (Italy) and, most recently, the 13th WCI (July 2017, London, UK).
Twice funded by the CFI (Leaders Fund) with which state-of-the-art, medium throughput, quantitative real-time PCR systems were acquire for the research program. The team can now exploit sections of neutrophils’ transcriptomes and of other tissues to characterize their activation profile (Boudreau et al., 2014; Duchez et al., 2015; Laflamme et al., 2014) and use distinctive alterations therein for diagnostic purposes. Dr. Pouliot was invited present this emerging piece of work at “The Society for Leukocyte Biology’s 49th Annual Meeting, in Verona (Italy) in September of 2016.
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- Les organisateurs du congrès Neutrophil récompensés par le Cercle des ambassadeurs de Québec 2019-01-31
- Une nouvelle piste contre l’arthrite : Des chercheurs de la Faculté de médecine ont découvert une cible thérapeutique intéressante pour mieux traiter cette maladie articulaire 2015-07-06
- Des suspects inattendus : On soupçonnait les bactéries de causer les réactions inflammatoires qui suivent parfois les transfusions de plaquettes. Mauvaise cible, avancent des chercheurs de Médecine. 2014-09-18
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2705, boulevard Laurier
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Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.Journal Article
J Immunol, 158 (10), pp. 4930-7, 1997, ISSN: 0022-1767.
Regulation of tumor necrosis factor-alpha and IL-1 beta synthesis by thromboxane A2 in nonadherent human monocytes.Journal Article
J Immunol, 158 (1), pp. 351-8, 1997, ISSN: 0022-1767.
Colocalization of cytosolic phospholipase A2, 5-lipoxygenase, and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils.Journal Article
Eur J Biochem, 238 (1), pp. 250-8, 1996, ISSN: 0014-2956.
Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx.Journal Article
Biochem J, 310 ( Pt 2) , pp. 681-8, 1995, ISSN: 0264-6021.
Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils.Journal Article
J Exp Med, 179 (4), pp. 1225-32, 1994, ISSN: 0022-1007.
Granulocyte-macrophage colony-stimulating factor enhances 5-lipoxygenase levels in human polymorphonuclear leukocytes.Journal Article
J Immunol, 152 (2), pp. 851-8, 1994, ISSN: 0022-1767.
Induction by chemokines of lipid mediator synthesis in granulocyte-macrophage colony-stimulating factor-treated human neutrophils.Journal Article
J Immunol, 151 (11), pp. 6399-409, 1993, ISSN: 0022-1767.
Enhancement by GM-CSF of agonist-induced 5-lipoxygenase activation in human neutrophils involves protein synthesis and gene transcription.Journal Article
J Lipid Mediat, 6 (1-3), pp. 59-67, 1993, ISSN: 0921-8319.
Potentiation of bleomycin lethality and inhibition of DNA repair by anti-calmodulin drugs is associated with the selective inhibition of expression of a 55 Kd calmodulin-binding proteinBook Chapter
AW, Norman; AW, Norman; TC, Vanaman; AR, Means (Ed.): Calcium-binding proteins in health and disease, pp. 618-620, San Diego, Academic Press, 1987, ISBN: 012521040X.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Defective prostaglandin biosynthesis pathways and abnormal crosstalk at the endometrial/peritoneal interface: role in the pathophysiology of endometriosis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2012-10-01 to 2021-03-31
Recently finished projects
- Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
Current extramural services: Laval University Delegate at CIHR; Member of the CIHR College of reviewers; Reviewer for Projects scheme (CIHR); On the editorial board of 6 journals. Until recently: Co-Chair of the Institute Advisory Board, Institute of Musculoskeletal Health and Arthritis (IMHA) at CIHR; Chair, Scientific Advisory Board, The Arthritis Society (TAS); Co-Chair, training and education committee, Canadian Arthritis Network (CAN), SO, or regular member of CIHR, CFI, AHFMR and TAS/CAN review committees.
Recent international outreach activities
- Invited speaker: "Early tyrosine phosphorylation and comparative proteomics provide new insights into adenosine A2A receptor activities in human neutrophils", The Society for leukocyte biology's 49th annual meeting, Verona ITALIE, 2016-09-15 to 2016-09-17
Recent national outreach activities
- Member of the evaluation comittee: Compétition "projets" stages 1 et 2, IRSC, , 2017 to 2017
- CIHR: Institutional Advisory Board (IAB), IMHA. Regular Member, , , 2011-09-01 to 2016-06-01
- Member of the evaluation comittee: La Société d'arthrite du Canada, , , Since 2002-01-01