Dr. Marc Pouliot is a Full Professor in the Department of Microbiology-Infectious Diseases and Immunology, of the Laval University School of Medicine, leading a knowledge development program on the implication of neutrophils in inflammatory responses. After completing his Ph.D in 1994 in molecular biology at Laval University, under the supervision of Dr. Pierre-Borgeat, Dr. Pouliot specialized in immunology during two postdoctoral fellowships, at the Royal Adelaide Hospital (South Australia), and then at the Brigham and Women’s Hospital (Harvard Medical School, Boston, USA), he joined in 2000 (Full professor since 2009). He was awarded competitive scholarships, continuously from Master’s degree to Senior Investigator level, from: Fonds canadien pour l’avancement de la recherche (Masters); Fonds de la Recherche en Santé du Québec (Ph.D.); Medical Research Council (Post-doc, and Centennial Distinguished Post-doc awards); Canadian Pain Society, Banting Research Foundation, CAN, TAS and CIHR (New Investigator & Investigator); and from FRSQ (Junior & Senior Investigator). As PI, he has been funded by the Canadian Institutes of Health Research (CIHR) for the last 17 years, and by The Arthritis Society (TAS), the Canadian Arthritis Network (CAN; a National Center of Excellence), the National Institutes of Health (US), and the Canadian Foundation for Innovation (CFI). Some career numbers: Peer-reviewed publications: 53, Book chapters: 5, h index: 25 (2394 citations, 882 since 2012), i10 index: 33 (Google Scholar), Funding (as PI): >2M$. He has supervised 4 post-docs, 30 graduate students and trainees, and has reviewed more than 45 Ph.D. theses and Master’s memoirs.
Adenosine & neutrophils
Dr. Pouliot’s research program focusses on extricating the full worth of neutrophils in innate immunity. He and his team have contributed to show that neutrophils can produce a tightly regulated array of mediators, including eicosanoids, cytokines, and chemokines, that can influence each of the phases of an inflammatory response. His team showed that engagement of the adenosine A2A receptor represents a master key in re-programming neutrophils, on one hand by shifting their leukotriene B4-generating capacity toward prostaglandin E2 instead, and on the other hand, by preventing the generation of inflammatory cytokines, including TNF. How A2A receptor engagement can favour the resolution phase of inflammation through its actions on neutrophils has raised considerable interest, exemplified by invited oral presentations during: the 6th World Congress on Inflammation (WCI, Vancouver), at the 8th WCI (Copenhagen), the Purines Congress (Copenhagen), the opening session of the Banff Inflammation Workshop, the 9th WCI (Tokyo), the joint SLB and Neutrophil 2016 in Verona (Italy) and, most recently, the 13th WCI (July 2017, London, UK).
Twice funded by the CFI (Leaders Fund) with which state-of-the-art, medium throughput, quantitative real-time PCR systems were acquire for the research program. The team can now exploit sections of neutrophils’ transcriptomes and of other tissues to characterize their activation profile (Boudreau et al., 2014; Duchez et al., 2015; Laflamme et al., 2014) and use distinctive alterations therein for diagnostic purposes. Dr. Pouliot was invited present this emerging piece of work at “The Society for Leukocyte Biology’s 49th Annual Meeting, in Verona (Italy) in September of 2016.
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- Les organisateurs du congrès Neutrophil récompensés par le Cercle des ambassadeurs de Québec 2019-01-31
- Une nouvelle piste contre l’arthrite : Des chercheurs de la Faculté de médecine ont découvert une cible thérapeutique intéressante pour mieux traiter cette maladie articulaire 2015-07-06
- Des suspects inattendus : On soupçonnait les bactéries de causer les réactions inflammatoires qui suivent parfois les transfusions de plaquettes. Mauvaise cible, avancent des chercheurs de Médecine. 2014-09-18
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Age-related decline of the acute local inflammation response: a mitigating role for the adenosine A2A receptor.Journal Article
Aging (Albany NY), 9 (10), pp. 2083-2097, 2017, ISSN: 1945-4589.
Early tyrosine phosphorylation events following adenosine A2A receptor in human neutrophils: identification of regulated pathways.Journal Article
J Leukoc Biol, 102 (3), pp. 829-836, 2017, ISSN: 0741-5400.
Promotion of angiogenesis and proliferation cytokines patterns in peritoneal fluid from women with endometriosis.Journal Article
J Reprod Immunol, 116 , pp. 1-6, 2016, ISSN: 0165-0378.
Augmented Angiogenic Factors Expression via FP Signaling Pathways in Peritoneal Endometriosis.Journal Article
J Clin Endocrinol Metab, 101 (12), pp. 4752-4763, 2016, ISSN: 0021-972X.
Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.Journal Article
Proc Natl Acad Sci U S A, 112 (27), pp. E3564-73, 2015, ISSN: 0027-8424.
Abnormal Expression of Prostaglandins E2 and F2α Receptors and Transporters in Patients with Endometriosis.Journal Article
Biomed Res Int, 2015 , pp. 808146, 2015.
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation.Journal Article
Blood, 124 (14), pp. 2173-83, 2014, ISSN: 0006-4971.
TNF-α expression in neutrophils and its regulation by glycogen synthase kinase-3: a potentiating role for lithium.Journal Article
FASEB J, 28 (8), pp. 3679-90, 2014, ISSN: 0892-6638.
Evidence of impairment of normal inflammatory reaction by a high-fat diet.Journal Article
Genes Immun, 15 (4), pp. 224-32, 2014, ISSN: 1466-4879.
Characterization of the Na/HCO3(-) cotransport in human neutrophils.Journal Article
Cell Physiol Biochem, 33 (4), pp. 982-90, 2014, ISSN: 1015-8987.
- Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
- Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Defective prostaglandin biosynthesis pathways and abnormal crosstalk at the endometrial/peritoneal interface: role in the pathophysiology of endometriosis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2012-10-01 to 2021-03-31
Current extramural services: Laval University Delegate at CIHR; Member of the CIHR College of reviewers; Reviewer for Projects scheme (CIHR); On the editorial board of 6 journals. Until recently: Co-Chair of the Institute Advisory Board, Institute of Musculoskeletal Health and Arthritis (IMHA) at CIHR; Chair, Scientific Advisory Board, The Arthritis Society (TAS); Co-Chair, training and education committee, Canadian Arthritis Network (CAN), SO, or regular member of CIHR, CFI, AHFMR and TAS/CAN review committees.
Recent international outreach activities
- Invited speaker: "Early tyrosine phosphorylation and comparative proteomics provide new insights into adenosine A2A receptor activities in human neutrophils", The Society for leukocyte biology's 49th annual meeting, Verona ITALIE, 2016-09-15 to 2016-09-17
Recent national outreach activities
- Member of the evaluation comittee: Compétition "projets" stages 1 et 2, IRSC, , 2017 to 2017
- CIHR: Institutional Advisory Board (IAB), IMHA. Regular Member, , , 2011-09-01 to 2016-06-01
- Member of the evaluation comittee: La Société d'arthrite du Canada, , , Since 2002-01-01