Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.

Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.

CHUL
2705, boulevard Laurier
RC-709
Québec, Québec
Canada G1V 4G2
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Papadopoulou B, Roy G, Dey S, Rosen BP, Olivier M, Ouellette M

Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae.

Journal Article

Biochem Biophys Res Commun, 224 (3), pp. 772-8, 1996, ISSN: 0006-291X.

Abstract | Links:

Ouellette M, Papadopoulou B

Mechanisms of drug resistance in Leishmania.

Journal Article

Parasitol Today, 9 (5), pp. 150-3, 1993, ISSN: 0169-4758.

Abstract | Links:

Papadopoulou B, Roy G, Ouellette M

A novel antifolate resistance gene on the amplified H circle of Leishmania.

Journal Article

EMBO J, 11 (10), pp. 3601-8, 1992, ISSN: 0261-4189.

Abstract | Links:

Beaulieu D, Ouellette M, Bergeron MG, Roy PH

Characterization of a plasmid isolated from Branhamella catarrhalis and detection of plasmid sequences within the genome of a B. catarrhalis strain.

Journal Article

Plasmid, 20 (2), pp. 158-62, 1988, ISSN: 0147-619X.

Abstract | Links:

Martel AY, Gosselin P, Ouellette M, Roy PH, Bergeron MG

Isolation and molecular characterization of beta-lactamase-producing Haemophilus parainfluenzae from the genital tract.

Journal Article

Antimicrob Agents Chemother, 31 (6), pp. 966-8, 1987, ISSN: 0066-4804.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2024-11-06
  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-04-01 to 2024-03-31
  • Genomics of antimicrobial resistance and drug/target discovery, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2019-07-01 to 2027-06-30
  • Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., Subvention, Centre de recherches pour le développement international, Appel de propositions : Élaborer des solutions vétérinaires innovatrices pour la résistance aux antimicrobiens, from 2019-04-01 to 2022-03-31
  • MAchine learning for diGItal diagnosTICS of antimicrobial resistance, Subvention, Instituts de recherche en santé du Canada, Joint Programming Initiative on Antimicrobial Resistance JPIAMR, from 2019-10-01 to 2022-09-30

Recently finished projects

  • Canada Research Chair in Medical genomics, Partenariat, Secrétariat des programmes interorganismes à l’intention des établissements, Fonds des leaders John-R.-Evans - CRC (anciennement : Chaires de recherche du Canada - infrastructure et Fonds des leaders - Volet 2), from 2018-08-01 to 2019-12-31
  • Drug resistance and drug targets in the protozoan parasite Leishmania, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2020-03-31
  • Drug resistance mechanisms in the human pathogen Leishmania, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2005-10-01 to 2019-06-30
  • Expression profiling in antibiotic resistant Streptococcus pneumoniae, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2006-10-01 to 2019-06-30
  • Génomique de la résistance aux antimicrobiens - visiting scholars, Subvention, Université de Bordeaux, from 2018-09-18 to 2019-07-31
  • One carbon metabolism in the human parasite Leishmania., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2007-04-01 to 2019-06-30
  • Research Program in Antimicrobial Resistance, Subvention, Instituts de recherche en santé du Canada, Supplément aux programmes de recherche : Directeurs scientifique, from 2010-01-01 to 2019-06-30
Data provided by the Université Laval research projects registery