Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.

Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.

CHUL
2705, boulevard Laurier
RC-709
Québec, Québec
Canada G1V 4G2
200 entries « 1 of 20 »

El Khoury JY, Maure A, Gingras H, Leprohon P, Ouellette M

Chemogenomic Screen for Imipenem Resistance in Gram-Negative Bacteria.

Journal Article

mSystems, 4 (6), 2019, ISSN: 2379-5077.

Abstract | Links:

Bhattacharya A, Sharma M, Pakkinathan C, Rosen BP, Leprohon P, Ouellette M

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum.

Journal Article

mSystems, 4 (5), 2019, ISSN: 2379-5077.

Abstract | Links:

Wallace RL, Ouellette M, Jean J

Effect of UV-C light or hydrogen peroxide wipes on the inactivation of methicillin-resistant Staphylococcus aureus, Clostridium difficile spores and norovirus surrogate.

Journal Article

J Appl Microbiol, 127 (2), pp. 586-597, 2019, ISSN: 1364-5072.

Abstract | Links:

Raymond F, Boissinot M, Ouameur AA, Deraspe M, Plante PL, Kpanou SR, Berube E, Huletsky A, Roy PH, Ouellette M, Bergeron MG, Corbeil J

Culture-enriched human gut microbiomes reveal core and accessory resistance genes.

Journal Article

Microbiome, 7 (1), pp. 56, 2019, ISSN: 2049-2618.

Abstract | Links:

Gingras H, Patron K, Bhattacharya A, Leprohon P, Ouellette M

Gain- and Loss-of-Function Screens Coupled to Next-Generation Sequencing for Antibiotic Mode of Action and Resistance Studies in Streptococcus pneumoniae.

Journal Article

Antimicrob Agents Chemother, 63 (5), 2019, ISSN: 0066-4804.

Abstract | Links:

Potvin JE, Leprohon P, Gazanion E, Sharma M, Fernandez-Prada C, Ouellette M

Cos-Seq: A High-Throughput Gain-of-Function Screen for Drug Resistance Studies in Leishmania.

Journal Article

Methods Mol Biol, 1971 , pp. 141-167, 2019, ISSN: 1064-3745.

Abstract | Links:

Bhattacharya A, Ouellette M

New insights with miltefosine unresponsiveness in Brazilian Leishmania infantum isolates.

Journal Article

EBioMedicine, 37 , pp. 13-14, 2018, ISSN: 2352-3964.

| Links:

Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, Ouellette M, Outterson K, Patel J, Cavaleri M, Cox EM, Houchens CR, Grayson ML, Hansen P, Singh N, Theuretzbacher U, Magrini N, WHO Pathogens Priority List Working Group

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.

Journal Article

Lancet Infect Dis, 18 (3), pp. 318-327, 2018, ISSN: 1473-3099.

Abstract | Links:

Gingras H, Dridi B, Leprohon P, Ouellette M

Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli.

Journal Article

Microb Genom, 4 (2), 2018, ISSN: 2057-5858.

Abstract | Links:

Fernandez-Prada C, Sharma M, Plourde M, Bresson E, Roy G, Leprohon P, Ouellette M

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms.

Journal Article

Int J Parasitol Drugs Drug Resist, 8 (2), pp. 165-173, 2018, ISSN: 2211-3207.

Abstract | Links:

200 entries « 1 of 20 »
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Active projects

  • Canada Research Chair in Medical genomics, Partenariat, Secrétariat des programmes interorganismes à l’intention des établissements, Fonds des leaders John-R.-Evans - CRC (anciennement : Chaires de recherche du Canada - infrastructure et Fonds des leaders - Volet 2), from 2018-08-01 to 2019-12-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2020-04-30
  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-04-01 to 2024-03-31
  • Drug resistance and drug targets in the protozoan parasite Leishmania, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2020-03-31
  • Genomics of antimicrobial resistance and drug/target discovery, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2019-07-01 to 2027-06-30
  • Les bactériocines : une alternative naturelle fort prometteuse pour le remplacement des antibiotiques en production avicole., Subvention, Centre de recherches pour le développement international, Appel de propositions : Élaborer des solutions vétérinaires innovatrices pour la résistance aux antimicrobiens, from 2019-04-01 to 2022-03-31
  • One carbon metabolism in the human parasite Leishmania., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2007-04-01 to 2020-03-31

Recently finished projects

  • Drug resistance mechanisms in the human pathogen Leishmania, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2005-10-01 to 2019-09-30
  • Expression profiling in antibiotic resistant Streptococcus pneumoniae, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2006-10-01 to 2019-06-30
  • Génomique de la résistance aux antimicrobiens - visiting scholars, Subvention, Université de Bordeaux, from 2018-09-18 to 2019-07-31
  • Institut des maladies infectieuses et immunitaires des IRSC, Subvention, Instituts de recherche en santé du Canada, Programme de subvention d'appui à l'Institut (SAI), from 2010-01-01 to 2018-06-30
  • Research Program in Antimicrobial Resistance, Subvention, Instituts de recherche en santé du Canada, Supplément aux programmes de recherche : Directeurs scientifique, from 2010-01-01 to 2019-06-30
  • Support aux opérations du laboratoire CHUL, Subvention, Institutionnel - BDR, Fonds général de recherche du CRSNG, from 2010-04-01 to 2018-06-30
Data provided by the Université Laval research projects registery