Dr. Marc Ouellette is an investigator at the Infectious Diseases and Immunity Axis of the Research Centre of the CHU de Québec-Laval University. He is also a full professor at the Department of Microbiology-Infectious Diseases and Immunology at the Laval University School of Medicine. His work focuses on antimicrobial resistance. Dr. Ouellette holds a Canada Research Chair in antimicrobial resistance and was the Scientific Director of the CIHR Institute of Infection and Immunity from 2010-2018. He is a fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences.

Dr. Ouelette’s work focuses on the protozoan parasite Leishmania and on different bacteria, including the pneumococcus. Leishmania is a neglected tropical disease that affects over 12 million people, while antibiotic resistance is a major public health issue that is receiving unprecedented political attention. His team uses several screens coupled to next-generation sequencing to find novel biomarkers of resistance in parasites and bacteria. Their screens are also used to identify new drug cellular targets against new molecules or also to define death and survival pathways that could be exploited for novel therapeutic strategies.

2705, boulevard Laurier
Québec, Québec
Canada G1V 4G2
194 entries « 1 of 39 »

Bhattacharya A, Ouellette M

New insights with miltefosine unresponsiveness in Brazilian Leishmania infantum isolates.

Journal Article

EBioMedicine, 37 , pp. 13-14, 2018, ISSN: 2352-3964.

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Tacconelli E, Carrara E, Savoldi A, Harbarth S, Mendelson M, Monnet DL, Pulcini C, Kahlmeter G, Kluytmans J, Carmeli Y, Ouellette M, Outterson K, Patel J, Cavaleri M, Cox EM, Houchens CR, Grayson ML, Hansen P, Singh N, Theuretzbacher U, Magrini N, WHO Pathogens Priority List Working Group

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.

Journal Article

Lancet Infect Dis, 18 (3), pp. 318-327, 2018, ISSN: 1473-3099.

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Gingras H, Dridi B, Leprohon P, Ouellette M

Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli.

Journal Article

Microb Genom, 2018, ISSN: 2057-5858.

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Fernandez-Prada C, Sharma M, Plourde M, Bresson E, Roy G, Leprohon P, Ouellette M

High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms.

Journal Article

Int J Parasitol Drugs Drug Resist, 8 (2), pp. 165-173, 2018, ISSN: 2211-3207.

Abstract | Links:

El Khoury JY, Boucher N, Bergeron MG, Leprohon P, Ouellette M

Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae.

Journal Article

Sci Rep, 7 (1), pp. 14587, 2017, ISSN: 2045-2322.

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194 entries « 1 of 39 »

Active projects

  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Chaire de recherche du Canada sur la résistance aux antiantimicrobiens, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-04-01 to 2024-03-31
  • Drug resistance mechanisms in the human pathogen Leishmania, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2005-10-01 to 2019-09-30
  • Expression profiling in antibiotic resistant Streptococcus pneumoniae, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2006-10-01 to 2019-06-30
  • One carbon metabolism in the human parasite Leishmania., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2007-04-01 to 2020-03-31

Recently finished projects

  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
  • Centre de recherche sur les interactions hôte-parasite (CRIHP), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques, from 2015-04-01 to 2017-03-31
  • Chaire de recherche du Canada en résistance antimicrobienne, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2010-04-01 to 2017-03-31
  • Human and Microbial Integrative Genomics, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds de l'avant-garde (FA), from 2012-09-01 to 2016-08-31
  • Identification of antibiotic adjuvant targets in Gram-negative bacteria. (fonds 0493), Subvention, Fondation de l'Université Laval, from 2014-11-05 to 2016-11-04
  • Institut des maladies infectieuses et immunitaires des IRSC, Subvention, Instituts de recherche en santé du Canada, Programme de subvention d'appui à l'Institut (SAI), from 2010-01-01 to 2018-06-30
  • Research Program in Antimicrobial Resistance, Subvention, Instituts de recherche en santé du Canada, Supplément aux programmes de recherche : Directeurs scientifique, from 2010-01-01 to 2018-12-31
  • Support aux opérations du laboratoire CHUL, Subvention, Institutionnel - BDR, Fonds général de recherche du CRSNG, from 2010-04-01 to 2018-06-30
Data provided by the Université Laval research projects registery