Dr. Marc-Étienne Huot holds a PhD in Cellular and Molecular Biology from Laval University. His laboratory, established at the CHU Research Center of Québec – at l’Hôtel-Dieu de Québec, studies the role of RNA-binding proteins in the various processes leading to the formation of metastases.

 Dr. Huot’s laboratory is studying the mechanisms by which RNA-binding proteins regulate metastatic dissemination (Thematic 1), as well as cellular metabolism during tumor progression (Thematic 2).

Thematic 1 – Role of RNA-binding proteins in the regulation of tumor progression and metastasis formation. The involvement of mRNA regulation in tumor progression is often overlooked. Dr. Huot’s research attempts to overcome this omission by determining how RNA-binding proteins can regulate the spread of cancer cells, a complex process that allows them to leave the primary tumor to colonize and form secondary tumors (metastases) in distant tissues. Indeed, his results indicate that RNA-binding proteins (notably Sam68) can regulate several mechanisms essential to the formation of metastases, such as cell migration and adhesion. The hypothesis is that deregulation of RNA-binding protein activity affects the ability of metastatic cells to target the microenvironment of specific tissues. The results of his work will offer new therapeutic strategies to block tumor progression and thus prevent the formation of metastases.

Thematic 2 – Identification of non-canonical mTOR regulatory pathways in the control of cellular metabolism and tumor progression. Maintaining cell integrity requires close control of the cellular metabolism. Our second research theme concerns the regulation of mTOR, a central protein of cellular metabolism. In this theme, Dr. Huot is studying two new regulatory mechanisms affecting the mTOR protein. Part of his research attempts to elucidate how RNA-binding proteins associate with specific sequences present in mTOR mRNA to regulate splicing, stability, and activity. The second part concerns a mechanism that deregulates normal metabolic functions. This deregulation is caused by mutations frequently found in low-grade brain tumors, which would promote tumor progression by promoting the proliferation and survival of cancer cells. These results will make it possible to understand these new modes of regulation of cell metabolism that are usually deregulated in treatment-refractory cancers.

L'Hôtel-Dieu de Québec
9, rue McMahon
2734-1
Québec, Québec
Canada G1R 2J6

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Huot ME, Vogel G, Zabarauskas A, Ngo CT, Coulombe-Huntington J, Majewski J, Richard S

The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis.

Journal Article

Mol Cell, 46 (2), pp. 187-99, 2012, ISSN: 1097-2765.

Abstract | Links:

Huot ME, Bisson N, Moss T, Khandjian EW

Manipulating the fragile X mental retardation proteins in the frog.

Journal Article

Results Probl Cell Differ, 54 , pp. 165-79, 2012, ISSN: 0080-1844.

Abstract | Links:

Huot ME, Vogel G, Richard S

Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor.

Journal Article

J Biol Chem, 284 (46), pp. 31903-13, 2009, ISSN: 0021-9258.

Abstract | Links:

Lukong KE, Huot ME, Richard S

BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest.

Journal Article

Cell Signal, 21 (9), pp. 1415-22, 2009, ISSN: 0898-6568.

Abstract | Links:

Huot ME, Brown CM, Lamarche-Vane N, Richard S

An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization.

Journal Article

Mol Cell Biol, 29 (7), pp. 1933-43, 2009, ISSN: 0270-7306.

Abstract | Links:

Richard S, Vogel G, Huot ME, Guo T, Muller WJ, Lukong KE

Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis.

Journal Article

Oncogene, 27 (4), pp. 548-56, 2008, ISSN: 0950-9232.

Abstract | Links:

Huot ME, Bisson N, Davidovic L, Mazroui R, Labelle Y, Moss T, Khandjian EW

The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.

Journal Article

Mol Biol Cell, 16 (9), pp. 4350-61, 2005, ISSN: 1059-1524.

Abstract | Links:

Davidovic L, Huot ME, Khandjian EW

Lost once, the Fragile X Mental Retardation protein is now back onto brain polyribosomes.

Journal Article

RNA Biol, 2 (1), pp. 1-3, 2005, ISSN: 1547-6286.

Abstract | Links:

Khandjian EW, Huot ME, Tremblay S, Davidovic L, Mazroui R, Bardoni B

Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles.

Journal Article

Proc Natl Acad Sci U S A, 101 (36), pp. 13357-62, 2004, ISSN: 0027-8424.

Abstract | Links:

Mazroui R, Huot ME, Tremblay S, Boilard N, Labelle Y, Khandjian EW

Fragile X Mental Retardation protein determinants required for its association with polyribosomal mRNPs.

Journal Article

Hum Mol Genet, 12 (23), pp. 3087-96, 2003, ISSN: 0964-6906.

Abstract | Links:

24 entries « 2 of 3 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Defining the mechanism of oncometabolite-mediated DEPTOR degradation in brain cancer, Subvention, Société de recherche sur le cancer, Subvention de fonctionnement, from 2019-09-01 to 2021-08-31
  • Rôles des protéines liant l'ARN et du métabolisme cellulaire dans la tumorigenèse et la progression tumorale, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2021-06-30
  • SAM68-induced regulation of cellular metabolism through mTOR mRNA splicing and stabilization, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2019-04-01 to 2024-03-31
Data provided by the Université Laval research projects registery