Dr. Louis Lacombe is a urologist-oncologist and clinical researcher at the CHU de Québec, and more specifically at L’Hôtel-Dieu de Québec.

Dr. Lacombe completed his medical training in Sherbrooke in 1988 and then completed a specialization in Urology at Laval University in 1993. Subsequently, Dr. Lacombe traveled to New York at the Memorial Sloan-Kettering Cancer Center associated with Cornell University to perform a subspecialisation in uro-oncology. This subspecialisation ended in 1996.

Following this subspecialisation, Dr. Lacombe joined the Urology Department of the CHU de Québec in July 1996. As a urologist, Dr. Lacombe specializes in complex surgeries associated with prostate, kidney, testicular and bladder cancer. He also collaborates in kidney transplant surgery.

Research at the Experimental Uro-oncology Laboratory aims to improve the diagnosis, prognosis, and therapy of prostate, bladder, and kidney cancers, and thus cover many aspects of research, from basic research to applied research. His interest is mainly focused on bladder cancer.

Dr. Lacombe is also actively involved in clinical research by conducting numerous Phase I, Phase II or Phase III clinical trials to test new drugs or therapies. He has been the principal investigator or co-investigator in more than 120 studies since the beginning of his career.

He has published more than 110 scientific papers and more than 250 scientific abstracts, and has presented at many international conferences.

Throughout his career, he has been awarded the FRQS Junior I and II Clinician Fellowship. He is currently a full professor in the Department of Surgery, and since 2016 he is the Director of the University Department of Surgery at the School of Medicine at Laval University.

L'Hôtel-Dieu de Québec
10, rue McMahon
1852-4
Québec, Québec
Canada G1R 2J6
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Bolduc S, Lacombe L, Naud A, Gregoire M, Fradet Y, Tremblay RR

Urinary PSA: a potential useful marker when serum PSA is between 2.5 ng/mL and 10 ng/mL.

Journal Article

Can Urol Assoc J, 1 (4), pp. 377-81, 2007, ISSN: 1911-6470.

Abstract | Links:

Inman BA, Sebo TJ, Frigola X, Dong H, Bergstralh EJ, Frank I, Fradet Y, Lacombe L, Kwon ED

PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression.

Journal Article

Cancer, 109 (8), pp. 1499-505, 2007, ISSN: 0008-543X.

Abstract | Links:

Meyer F, Tetu B, Bairati I, Lacombe L, Fradet Y

Prostatic intraepithelial neoplasia in TURP specimens and subsequent prostate cancer.

Journal Article

Can J Urol, 13 (5), pp. 3255-60, 2006, ISSN: 1195-9479.

Abstract | Links:

Decobert M, Larue H, Bergeron A, Harel F, Pfister C, Rousseau F, Lacombe L, Fradet Y

Polymorphisms of the human NRAMP1 gene are associated with response to bacillus Calmette-Guerin immunotherapy for superficial bladder cancer.

Journal Article

J Urol, 175 (4), pp. 1506-11, 2006, ISSN: 0022-5347.

Abstract | Links:

Hervouet S, Savard J, Simard S, Ivers H, Laverdiere J, Vigneault E, Fradet Y, Lacombe L

Psychological functioning associated with prostate cancer: cross-sectional comparison of patients treated with radiotherapy, brachytherapy, or surgery.

Journal Article

J Pain Symptom Manage, 30 (5), pp. 474-84, 2005, ISSN: 0885-3924.

Abstract | Links:

Inman BA, Harel F, Audet JF, Meyer F, Douville P, Fradet Y, Lacombe L

Insulin-like growth factor binding protein 2: an androgen-dependent predictor of prostate cancer survival.

Journal Article

Eur Urol, 47 (5), pp. 695-702, 2005, ISSN: 0302-2838.

Abstract | Links:

Savard J, Simard S, Hervouet S, Ivers H, Lacombe L, Fradet Y

Insomnia in men treated with radical prostatectomy for prostate cancer.

Journal Article

Psychooncology, 14 (2), pp. 147-56, 2005, ISSN: 1057-9249.

Abstract | Links:

Rigaud J, Tiguert R, Decobert M, Hovington H, Latulippe E, Laverdiere J, Larue H, Lacombe L, Fradet Y

Expression of p21 cell cycle protein is an independent predictor of response to salvage radiotherapy after radical prostatectomy.

Journal Article

Prostate, 58 (3), pp. 269-76, 2004, ISSN: 0270-4137.

Abstract | Links:

Inman BA, Harel F, Tiguert R, Lacombe L, Fradet Y

Routine nasogastric tubes are not required following cystectomy with urinary diversion: a comparative analysis of 430 patients.

Journal Article

J Urol, 170 (5), pp. 1888-91, 2003, ISSN: 0022-5347.

Abstract | Links:

Tiguert R, Rigaud J, Lacombe L, Laverdiere J, Fradet Y

Neoadjuvant hormone therapy before salvage radiotherapy for an increasing post-radical prostatectomy serum prostate specific antigen level.

Journal Article

J Urol, 170 (2 Pt 1), pp. 447-50, 2003, ISSN: 0022-5347.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Interaction between environment, diet, physical activities, and sexual habits, in the risk of prostate cancer. Validation of biomarkers to personnalize preventive interventions., Subvention, Société de recherche sur le cancer, Compétition GRePEC (SRC/FRSQ/MDEIE), from 2012-10-01 to 2021-12-31
  • Soutien à la recherche, Subvention, Université Laval - Soutien à la recherche, from 2017-07-01 to 2024-06-30
  • The Contribution of Non-Classical 11-oxy Androgens to Prostate Cancer Progression, Subvention, Cancer de la prostate Canada, Subvention de découverte, from 2019-04-01 to 2022-03-30

Recently finished projects

  • A Pan-Canadian initiative for the development of biomarker-driven approach to management of prostate cancer, Subvention, Centre hospitalier universitaire de Montréal, from 2012-04-01 to 2019-12-31
Data provided by the Université Laval research projects registery