Dr. Louis Flamand is a full professor and vice-chair of the department of microbiology-infectious disease-immunology at the Laval University School of Medicine and senior researcher in the division of infectious and immune diseases at the CHU de Quebec Research Center. Before joining Laval University, Dr. Flamand obtained his PhD at the University of Montreal and post-doctoral training that the National Institutes of Health and at the Institute of Human Virology (Maryland, USA). He received his MBA in pharmaceutical management from Laval University. Since 2008, he has been President of the biohazards risk committee at Laval University. He has also been a member of the HHV-6 Foundation scientific advisory board since 2006. Dr. Flamand has experience in pre-clinical development. Throughout his career, Dr. Flamand has received several competitive scholarship awards and continuous funding support from several funding agencies for his work in virology. Dr. Flamand is the author of more than 80 peer-reviewed publications and is lead Editor of the book “Human Herpesviruses HHV-6A, HHV-6B & HHV-7: Diagnosis and Clinical Management” 3rd edition.

Biological consequences of chromosomal integration by human herpesvirus 6 (HHV-6).

HHV-6 has the remarkable ability to integrate its genome in the cells that it infects. Remarkably, about 1% of the population carries a copy of the viral genome integrated in a chromosome of each cell. These individuals, referred to as inherited-chromosomally-integrated individuals (iciHHV-6), represent one of the main topics studied by Dr. Flamand and his team. HHV-6 genome integration occurs near the ends of chromosomes, in the telomere. Telomeres play a major role in cellular homeostasis by protecting the ends of chromosomes against the development of the DNA damage response, and play a key role in the long-term proliferative capacity of cells. It is therefore anticipated that the presence of the integrated virus in the telomere of ici HHV-6+ individuals may represent a risk factor for the development of various diseases. Dr. Flamand and his team recently reported that iciHHV-6+ subjects are 3X more at risk for developing angina pectoris, a cardiovascular disease (Gravel et al 2015 PNAS). Work in progress in the laboratory is aimed at better understanding the link between HHV-6 integration and the development of angina.

Understand the molecular and cellular mechanisms that lead to HHV-6 chromosomal integration.

Dr. Flamand’s laboratory is interested in identifying the mechanisms and viral/cellular factors underlying HHV-6 integration. Having successfully developed a cell culture model allowing them to study the integration of HHV-6, Dr. Flamand and his team are currently studying the viral and cellular proteins that play a role in HHV-6 integration process.

CHUL
2705, boulevard Laurier
T1-64
Québec, Québec
Canada G1V 4G2
89 entries « 2 of 9 »

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Journal Article

Proc Natl Acad Sci U S A, 115 (7), pp. E1550-E1559, 2018, ISSN: 0027-8424.

Abstract | Links:

Flamand L

Chromosomal Integration by Human Herpesviruses 6A and 6B.

Journal Article

Adv Exp Med Biol, 1045 , pp. 209-226, 2018, ISSN: 0065-2598.

Abstract | Links:

Gravel A, Dubuc I, Wallaschek N, Gilbert-Girard S, Collin V, Hall-Sedlak R, Jerome KR, Mori Y, Carbonneau J, Boivin G, Kaufer BB, Flamand L

Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration.

Journal Article

J Virol, 91 (14), 2017, ISSN: 0022-538X.

Abstract | Links:

Gilbert-Girard S, Gravel A, Artusi S, Richter SN, Wallaschek N, Kaufer BB, Flamand L

Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration.

Journal Article

J Virol, 91 (14), 2017, ISSN: 0022-538X.

Abstract | Links:

Collin V, Flamand L

HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B.

Journal Article

Viruses, 9 (7), 2017, ISSN: 1999-4915.

Abstract | Links:

Gravel A, Dubuc I, Brooks-Wilson A, Aronson KJ, Simard J, Velasquez-Garcia H, Spinelli JJ, Flamand L

Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer.

Journal Article

Cancer Epidemiol Biomarkers Prev, 26 (3), pp. 425-427, 2017, ISSN: 1055-9965.

Abstract | Links:

Hall Sedlak R, Hill JA, Nguyen T, Cho M, Levin G, Cook L, Huang ML, Flamand L, Zerr DM, Boeckh M, Jerome KR

Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR.

Journal Article

J Clin Microbiol, 54 (5), pp. 1223-7, 2016, ISSN: 0095-1137.

Abstract | Links:

Komaroff AL, Phan T, Flamand L, Pellett PE

Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7).

Journal Article

J Med Virol, 88 (12), pp. 2038-2043, 2016, ISSN: 0146-6615.

Abstract | Links:

Wallaschek N, Gravel A, Flamand L, Kaufer BB

The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration.

Journal Article

J Gen Virol, 97 (8), pp. 1899-1903, 2016, ISSN: 0022-1317.

Abstract | Links:

Wallaschek N, Sanyal A, Pirzer F, Gravel A, Mori Y, Flamand L, Kaufer BB

The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration.

Journal Article

PLoS Pathog, 12 (5), pp. e1005666, 2016, ISSN: 1553-7366.

Abstract | Links:

89 entries « 2 of 9 »
Signaler des ajouts ou des modifications

Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Human herpesvirus 6 and chromosomal integration, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-03-01 to 2021-02-28
  • The impact of antimalarial drugs in arthritis patients exposed to SARS-CoV-2- the CoVIRAL project, Subvention, La société d'arthrite, from 2020-04-01 to 2023-03-31
  • Understanding the pathogenesis of COVID-19, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), from 2020-03-01 to 2021-02-28

Recently finished projects

  • Caractérisation du rôle de la protéine précoce immédiate 1 dans l'intégration chromosomique des herpèsvirus humains, Subvention, MITACS Inc., Bourse de recherche Mitacs Globalink, from 2019-01-14 to 2019-06-06
  • Financement d'un projet de recherche dans l'axe MII, Subvention, Fondation du CHU de Québec, from 2019-11-11 to 2020-03-31
  • Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases, Subvention, Fondation des maladies du coeur et de l'AVC du Canada, Subventions de recherche, from 2017-04-01 to 2020-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2020-03-31
Data provided by the Université Laval research projects registery