Dr. Louis Flamand is a full professor and vice-chair of the department of microbiology-infectious disease-immunology at the Laval University School of Medicine and senior researcher in the division of infectious and immune diseases at the CHU de Quebec Research Center. Before joining Laval University, Dr. Flamand obtained his PhD at the University of Montreal and post-doctoral training that the National Institutes of Health and at the Institute of Human Virology (Maryland, USA). He received his MBA in pharmaceutical management from Laval University. Since 2008, he has been President of the biohazards risk committee at Laval University. He has also been a member of the HHV-6 Foundation scientific advisory board since 2006. Dr. Flamand has experience in pre-clinical development. Throughout his career, Dr. Flamand has received several competitive scholarship awards and continuous funding support from several funding agencies for his work in virology. Dr. Flamand is the author of more than 80 peer-reviewed publications and is lead Editor of the book “Human Herpesviruses HHV-6A, HHV-6B & HHV-7: Diagnosis and Clinical Management” 3rd edition.

Biological consequences of chromosomal integration by human herpesvirus 6 (HHV-6).

HHV-6 has the remarkable ability to integrate its genome in the cells that it infects. Remarkably, about 1% of the population carries a copy of the viral genome integrated in a chromosome of each cell. These individuals, referred to as inherited-chromosomally-integrated individuals (iciHHV-6), represent one of the main topics studied by Dr. Flamand and his team. HHV-6 genome integration occurs near the ends of chromosomes, in the telomere. Telomeres play a major role in cellular homeostasis by protecting the ends of chromosomes against the development of the DNA damage response, and play a key role in the long-term proliferative capacity of cells. It is therefore anticipated that the presence of the integrated virus in the telomere of ici HHV-6+ individuals may represent a risk factor for the development of various diseases. Dr. Flamand and his team recently reported that iciHHV-6+ subjects are 3X more at risk for developing angina pectoris, a cardiovascular disease (Gravel et al 2015 PNAS). Work in progress in the laboratory is aimed at better understanding the link between HHV-6 integration and the development of angina.

Understand the molecular and cellular mechanisms that lead to HHV-6 chromosomal integration.

Dr. Flamand’s laboratory is interested in identifying the mechanisms and viral/cellular factors underlying HHV-6 integration. Having successfully developed a cell culture model allowing them to study the integration of HHV-6, Dr. Flamand and his team are currently studying the viral and cellular proteins that play a role in HHV-6 integration process.

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83 entries « 2 of 9 »

Hall Sedlak R, Hill JA, Nguyen T, Cho M, Levin G, Cook L, Huang ML, Flamand L, Zerr DM, Boeckh M, Jerome KR

Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR.

Journal Article

J Clin Microbiol, 54 (5), pp. 1223-7, 2016, ISSN: 0095-1137.

Abstract | Links:

Komaroff AL, Phan T, Flamand L, Pellett PE

Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7).

Journal Article

J Med Virol, 88 (12), pp. 2038-2043, 2016, ISSN: 0146-6615.

Abstract | Links:

Wallaschek N, Gravel A, Flamand L, Kaufer BB

The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration.

Journal Article

J Gen Virol, 97 (8), pp. 1899-903, 2016, ISSN: 0022-1317.

Abstract | Links:

Wallaschek N, Sanyal A, Pirzer F, Gravel A, Mori Y, Flamand L, Kaufer BB

The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration.

Journal Article

PLoS Pathog, 12 (5), pp. e1005666, 2016, ISSN: 1553-7366.

Abstract | Links:

Trempe F, Gravel A, Dubuc I, Wallaschek N, Collin V, Gilbert-Girard S, Morissette G, Kaufer BB, Flamand L

Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins.

Journal Article

Nucleic Acids Res, 43 (12), pp. 6084-98, 2015, ISSN: 0305-1048.

Abstract | Links:

Gravel A, Dubuc I, Morissette G, Sedlak RH, Jerome KR, Flamand L

Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris.

Journal Article

Proc Natl Acad Sci U S A, 112 (26), pp. 8058-63, 2015, ISSN: 0027-8424.

Abstract | Links:

Artusi S, Nadai M, Perrone R, Biasolo MA, Palu G, Flamand L, Calistri A, Richter SN

The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand.

Journal Article

Antiviral Res, 118 , pp. 123-31, 2015, ISSN: 0166-3542.

Abstract | Links:

Iampietro M, Morissette G, Gravel A, Dubuc I, Rousseau M, Hasan A, O'Reilly RJ, Flamand L

Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes.

Journal Article

Eur J Immunol, 44 (12), pp. 3573-84, 2014, ISSN: 0014-2980.

Abstract | Links:

Kaufer BB, Flamand L

Chromosomally integrated HHV-6: impact on virus, cell and organismal biology.

Journal Article

Curr Opin Virol, 9 , pp. 111-8, 2014.

Abstract | Links:

Iampietro M, Morissette G, Gravel A, Flamand L

Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein.

Journal Article

J Virol, 88 (21), pp. 12452-63, 2014, ISSN: 0022-538X.

Abstract | Links:

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Active projects

  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Human herpesvirus 6 and chromosomal integration, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases, Subvention, Fondation des maladies du coeur et de l'AVC du Canada, Subventions de recherche, from 2017-04-01 to 2020-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2020-03-31

Recently finished projects

  • 11th International Conference on human herpesviruses 6A, 68 and 7., Subvention, Instituts de recherche en santé du Canada, Subvention de planification et dissémination, from 2018-12-01 to 2019-03-31
  • Caractérisation du rôle de la protéine précoce immédiate 1 dans l'intégration chromosomique des herpèsvirus humains, Subvention, MITACS Inc., Bourse de recherche Mitacs Globalink, from 2019-01-14 to 2019-06-06
Data provided by the Université Laval research projects registery