Dr. Louis Flamand is a full professor and vice-chair of the department of microbiology-infectious disease-immunology at the Laval University School of Medicine and senior researcher in the division of infectious and immune diseases at the CHU de Quebec Research Center. Before joining Laval University, Dr. Flamand obtained his PhD at the University of Montreal and post-doctoral training that the National Institutes of Health and at the Institute of Human Virology (Maryland, USA). He received his MBA in pharmaceutical management from Laval University. Since 2008, he has been President of the biohazards risk committee at Laval University. He has also been a member of the HHV-6 Foundation scientific advisory board since 2006. Dr. Flamand has experience in pre-clinical development. Throughout his career, Dr. Flamand has received several competitive scholarship awards and continuous funding support from several funding agencies for his work in virology. Dr. Flamand is the author of more than 80 peer-reviewed publications and is lead Editor of the book “Human Herpesviruses HHV-6A, HHV-6B & HHV-7: Diagnosis and Clinical Management” 3rd edition.

Biological consequences of chromosomal integration by human herpesvirus 6 (HHV-6).

HHV-6 has the remarkable ability to integrate its genome in the cells that it infects. Remarkably, about 1% of the population carries a copy of the viral genome integrated in a chromosome of each cell. These individuals, referred to as inherited-chromosomally-integrated individuals (iciHHV-6), represent one of the main topics studied by Dr. Flamand and his team. HHV-6 genome integration occurs near the ends of chromosomes, in the telomere. Telomeres play a major role in cellular homeostasis by protecting the ends of chromosomes against the development of the DNA damage response, and play a key role in the long-term proliferative capacity of cells. It is therefore anticipated that the presence of the integrated virus in the telomere of ici HHV-6+ individuals may represent a risk factor for the development of various diseases. Dr. Flamand and his team recently reported that iciHHV-6+ subjects are 3X more at risk for developing angina pectoris, a cardiovascular disease (Gravel et al 2015 PNAS). Work in progress in the laboratory is aimed at better understanding the link between HHV-6 integration and the development of angina.

Understand the molecular and cellular mechanisms that lead to HHV-6 chromosomal integration.

Dr. Flamand’s laboratory is interested in identifying the mechanisms and viral/cellular factors underlying HHV-6 integration. Having successfully developed a cell culture model allowing them to study the integration of HHV-6, Dr. Flamand and his team are currently studying the viral and cellular proteins that play a role in HHV-6 integration process.

CHUL
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
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Cloutier N, Gravel A, Flamand L

Multiplex detection and quantitation of latent and lytic transcripts of human herpesvirus-8 using RNase Protection Assay.

Journal Article

J Virol Methods, 122 (1), pp. 1-7, 2004, ISSN: 0166-0934.

Abstract | Links:

Berry KA, Borgeat P, Gosselin J, Flamand L, Murphy RC

Urinary metabolites of leukotriene B4 in the human subject.

Journal Article

J Biol Chem, 278 (27), pp. 24449-60, 2003, ISSN: 0021-9258.

Abstract | Links:

Gravel A, Tomoiu A, Cloutier N, Gosselin J, Flamand L

Characterization of the immediate-early 2 protein of human herpesvirus 6, a promiscuous transcriptional activator.

Journal Article

Virology, 308 (2), pp. 340-53, 2003, ISSN: 0042-6822.

Abstract | Links:

Janelle ME, Gravel A, Gosselin J, Tremblay MJ, Flamand L

Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1.

Journal Article

J Biol Chem, 277 (34), pp. 30665-74, 2002, ISSN: 0021-9258.

Abstract | Links:

Tardif M, Savard M, Flamand L, Gosselin J

Impaired protein kinase C activation/translocation in Epstein-Barr virus-infected monocytes.

Journal Article

J Biol Chem, 277 (27), pp. 24148-54, 2002, ISSN: 0021-9258.

Abstract | Links:

Gravel A, Gosselin J, Flamand L

Human Herpesvirus 6 immediate-early 1 protein is a sumoylated nuclear phosphoprotein colocalizing with promyelocytic leukemia protein-associated nuclear bodies.

Journal Article

J Biol Chem, 277 (22), pp. 19679-87, 2002, ISSN: 0021-9258.

Abstract | Links:

Gosselin J, Savard M, Tardif M, Flamand L, Borgeat P

Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4.

Journal Article

Clin Exp Immunol, 126 (3), pp. 494-502, 2001, ISSN: 0009-9104.

Abstract | Links:

Bélanger C, Gravel A, Tomoiu A, Janelle ME, Gosselin J, Tremblay MJ, Flamand L

Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation.

Journal Article

J Hum Virol, 4 (2), pp. 62-73, 2001, ISSN: 1090-9508.

Abstract | Links:

Savard M, Bélanger C, Tremblay MJ, Dumais N, Flamand L, Borgeat P, Gosselin J

EBV suppresses prostaglandin E2 biosynthesis in human monocytes.

Journal Article

J Immunol, 164 (12), pp. 6467-73, 2000, ISSN: 0022-1767.

Abstract | Links:

Savard M, Bélanger C, Tardif M, Gourde P, Flamand L, Gosselin J

Infection of primary human monocytes by Epstein-Barr virus.

Journal Article

J Virol, 74 (6), pp. 2612-9, 2000, ISSN: 0022-538X.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Human herpesvirus 6 and chromosomal integration, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases, Subvention, Fondation des maladies du coeur et de l'AVC du Canada, Subventions de recherche, from 2017-04-01 to 2020-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2020-03-31

Recently finished projects

  • 11th International Conference on human herpesviruses 6A, 68 and 7., Subvention, Instituts de recherche en santé du Canada, Subvention de planification et dissémination, from 2018-12-01 to 2019-03-31
  • Caractérisation du rôle de la protéine précoce immédiate 1 dans l'intégration chromosomique des herpèsvirus humains, Subvention, MITACS Inc., Bourse de recherche Mitacs Globalink, from 2019-01-14 to 2019-06-06
Data provided by the Université Laval research projects registery