Dr. Louis Flamand is a full professor and vice-chair of the department of microbiology-infectious disease-immunology at the Laval University School of Medicine and senior researcher in the division of infectious and immune diseases at the CHU de Quebec Research Center. Before joining Laval University, Dr. Flamand obtained his PhD at the University of Montreal and post-doctoral training that the National Institutes of Health and at the Institute of Human Virology (Maryland, USA). He received his MBA in pharmaceutical management from Laval University. Since 2008, he has been President of the biohazards risk committee at Laval University. He has also been a member of the HHV-6 Foundation scientific advisory board since 2006. Dr. Flamand has experience in pre-clinical development. Throughout his career, Dr. Flamand has received several competitive scholarship awards and continuous funding support from several funding agencies for his work in virology. Dr. Flamand is the author of more than 80 peer-reviewed publications and is lead Editor of the book “Human Herpesviruses HHV-6A, HHV-6B & HHV-7: Diagnosis and Clinical Management” 3rd edition.

Biological consequences of chromosomal integration by human herpesvirus 6 (HHV-6).

HHV-6 has the remarkable ability to integrate its genome in the cells that it infects. Remarkably, about 1% of the population carries a copy of the viral genome integrated in a chromosome of each cell. These individuals, referred to as inherited-chromosomally-integrated individuals (iciHHV-6), represent one of the main topics studied by Dr. Flamand and his team. HHV-6 genome integration occurs near the ends of chromosomes, in the telomere. Telomeres play a major role in cellular homeostasis by protecting the ends of chromosomes against the development of the DNA damage response, and play a key role in the long-term proliferative capacity of cells. It is therefore anticipated that the presence of the integrated virus in the telomere of ici HHV-6+ individuals may represent a risk factor for the development of various diseases. Dr. Flamand and his team recently reported that iciHHV-6+ subjects are 3X more at risk for developing angina pectoris, a cardiovascular disease (Gravel et al 2015 PNAS). Work in progress in the laboratory is aimed at better understanding the link between HHV-6 integration and the development of angina.

Understand the molecular and cellular mechanisms that lead to HHV-6 chromosomal integration.

Dr. Flamand’s laboratory is interested in identifying the mechanisms and viral/cellular factors underlying HHV-6 integration. Having successfully developed a cell culture model allowing them to study the integration of HHV-6, Dr. Flamand and his team are currently studying the viral and cellular proteins that play a role in HHV-6 integration process.

CHUL
2705, boulevard Laurier
T1-64
Québec, Québec
Canada G1V 4G2
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Khaddaj-Mallat R, Aldib N, Bernard M, Paquette AS, Ferreira A, Lecordier S, Saghatelyan A, Flamand L, ElAli A

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein.

Journal Article

Neurobiol Dis, 161 , 2021.

Abstract | Links:

Puhm F, Flamand L, Boilard E

Platelet extracellular vesicles in COVID-19: Potential markers and makers.

Journal Article

J Leukoc Biol, 2021.

Abstract | Links:

Wood ML, Veal CD, Neumann R, Suárez NM, Nichols J, Parker AJ, Martin D, Romaine SP, Codd V, Samani NJ, Voors AA, Tomaszewski M, Flamand L, Davison AJ, Royle NJ

Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals.

Journal Article

Elife, 10 , 2021.

Abstract | Links:

Mariani M, Zimmerman C, Rodriguez P, Hasenohr E, Aimola G, Gerrard DL, Richman A, Dest A, Flamand L, Kaufer B, Frietze S

Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites.

Journal Article

Front Cell Infect Microbiol, 11 , 2021.

Abstract | Links:

Zaid Y, Guessous F, Puhm F, Elhamdani W, Chentoufi L, Morris AC, Cheikh A, Jalali F, Boilard E, Flamand L

Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19.

Journal Article

Blood Adv, 5 (3), 2021.

| Links:

Artusi S, Ruggiero E, Nadai M, Tosoni B, Perrone R, Ferino A, Zanin I, Xodo L, Flamand L, Richter SN

Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1.

Journal Article

Viruses, 13 (2), 2021.

Abstract | Links:

Gravel A, Sanders W, Fournier E, Droit A, Moorman N, Flamand L

Mapping the Human Herpesvirus 6B transcriptome.

Journal Article

J Virol, 2021.

Abstract | Links:

Zaid Y, Dore E, Dubuc I, Archambault AS, Flamand O, Laviolette M, Flamand N, Boilard E, Flamand L

Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19.

Journal Article

J Allergy Clin Immunol, 148 (2), 2021.

Abstract | Links:

Archambault AS, Zaid Y, Rakotoarivelo V, Turcotte C, Dore E, Dubuc I, Martin C, Flamand O, Amar Y, Cheikh A, Fares H, El Hassani A, Tijani Y, Cote A, Laviolette M, Boilard E, Flamand L, Flamand N

High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients.

Journal Article

FASEB J, 35 (6), 2021.

Abstract | Links:

Collin V, Gravel A, Kaufer BB, Flamand L

The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres.

Journal Article

PLoS Pathog, 16 (7), 2020.

Abstract | Links:

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Active projects

  • Centre de recherche en arthrite (ARThrite), from 2020-11-03 to 2026-04-30
  • Coronavirus Variants Rapid Response Network: CoVaRR-Net, from 2021-03-01 to 2022-02-28
  • COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune Diseases / La réponse immunitaire au vaccin contre la COVID-19 chez des patients immunosupprimés en raison de maladies auto-immunes, from 2021-03-16 to 2023-03-31
  • Human herpesvirus 6 and chromosomal integration, from 2018-04-01 to 2023-03-31
  • Pathogenesis and immune escape potential of SARS-CoV-2 variants of concern, from 2021-06-01 to 2022-05-31
  • Pathogenic roles of platelets in sepsis, from 2020-03-01 to 2025-03-31
  • Role of antibodies in platelet response to SARS-CoV-2 and its variants, from 2021-06-01 to 2022-05-31
  • Role of platelets and their mother cell, the megakaryocyte, in COVID-19, from 2021-03-01 to 2022-02-28
  • The impact of antimalarial drugs in arthritis patients exposed to SARS-CoV-2- the CoVIRAL project, from 2020-04-01 to 2023-03-31

Recently finished projects

  • CanCOVID Network, from 2020-11-09 to 2021-06-24
  • COVID-19 trilogy: ARDS, inflammation and coagulopathy, from 2020-06-01 to 2021-05-31
  • Effect of cigarette smoke/e-cigarette vapor and SARS-CoV-2 infection on oral, nasal, and bronchial epithelial cell responses, from 2020-04-01 to 2021-04-30
  • Financement d'un projet de recherche dans l'axe MII, from 2019-11-11 to 2020-03-31
  • Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases, from 2017-04-01 to 2020-03-31
  • Pathogenic roles of platelets in sepsis, from 2019-04-01 to 2020-03-31
  • Seeking for innovative approaches in prevention and cure to COVID-19 disease, from 2020-11-01 to 2021-08-30
  • Understanding the pathogenesis of COVID-19, from 2020-03-01 to 2021-02-28
Data provided by the Université Laval research projects registery