Dr. Louis Flamand is a full professor and vice-chair of the department of microbiology-infectious disease-immunology at the Laval University School of Medicine and senior researcher in the division of infectious and immune diseases at the CHU de Quebec Research Center. Before joining Laval University, Dr. Flamand obtained his PhD at the University of Montreal and post-doctoral training that the National Institutes of Health and at the Institute of Human Virology (Maryland, USA). He received his MBA in pharmaceutical management from Laval University. Since 2008, he has been President of the biohazards risk committee at Laval University. He has also been a member of the HHV-6 Foundation scientific advisory board since 2006. Dr. Flamand has experience in pre-clinical development. Throughout his career, Dr. Flamand has received several competitive scholarship awards and continuous funding support from several funding agencies for his work in virology. Dr. Flamand is the author of more than 80 peer-reviewed publications and is lead Editor of the book “Human Herpesviruses HHV-6A, HHV-6B & HHV-7: Diagnosis and Clinical Management” 3rd edition.

Biological consequences of chromosomal integration by human herpesvirus 6 (HHV-6).

HHV-6 has the remarkable ability to integrate its genome in the cells that it infects. Remarkably, about 1% of the population carries a copy of the viral genome integrated in a chromosome of each cell. These individuals, referred to as inherited-chromosomally-integrated individuals (iciHHV-6), represent one of the main topics studied by Dr. Flamand and his team. HHV-6 genome integration occurs near the ends of chromosomes, in the telomere. Telomeres play a major role in cellular homeostasis by protecting the ends of chromosomes against the development of the DNA damage response, and play a key role in the long-term proliferative capacity of cells. It is therefore anticipated that the presence of the integrated virus in the telomere of ici HHV-6+ individuals may represent a risk factor for the development of various diseases. Dr. Flamand and his team recently reported that iciHHV-6+ subjects are 3X more at risk for developing angina pectoris, a cardiovascular disease (Gravel et al 2015 PNAS). Work in progress in the laboratory is aimed at better understanding the link between HHV-6 integration and the development of angina.

Understand the molecular and cellular mechanisms that lead to HHV-6 chromosomal integration.

Dr. Flamand’s laboratory is interested in identifying the mechanisms and viral/cellular factors underlying HHV-6 integration. Having successfully developed a cell culture model allowing them to study the integration of HHV-6, Dr. Flamand and his team are currently studying the viral and cellular proteins that play a role in HHV-6 integration process.

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90 entries « 1 of 9 »

Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M, Khalki L, Limami Y, Zaid N, Sadki K, Ben El Haj R, Mahir W, Belayachi L, Belefquih B, Benouda A, Cheikh A, Langlois MA, Cherrah Y, Flamand L, Guessous F, Boilard E

Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19.

Journal Article

Circ Res, 2020, ISSN: 0009-7330.

Abstract | Links:

Mouammine A, Gravel A, Dubuc I, Feroz Zada Y, Provost S, Busseuil D, Tardif JC, Dube MP, Flamand L

rs73185306 C/T Is Not a Predisposing Risk Factor for Inherited Chromosomally Integrated Human Herpesvirus 6A/B.

Journal Article

J Infect Dis, 221 (6), pp. 878-881, 2020, ISSN: 0022-1899.

Abstract | Links:

Komaroff AL, Zerr DM, Flamand L

Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7.

Journal Article

J Med Virol, 92 (1), pp. 4-10, 2020, ISSN: 0146-6615.

Abstract | Links:

Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L

Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration.

Journal Article

PLoS Pathog, 16 (4), pp. e1008496, 2020, ISSN: 1553-7366.

Abstract | Links:

Collin V, Gravel A, Kaufer BB, Flamand L

The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres.

Journal Article

PLoS Pathog, 16 (7), pp. e1008683, 2020, ISSN: 1553-7366.

Abstract | Links:

Peddu V, Dubuc I, Gravel A, Xie H, Huang ML, Tenenbaum D, Jerome KR, Tardif JC, Dube MP, Flamand L, Greninger AL

Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression In Vivo That Correlates with an Increased Antibody Immune Response.

Journal Article

J Virol, 94 (1), 2019, ISSN: 0022-538X.

Abstract | Links:

Boilard E, Flamand L

The role of the megakaryocyte in immunity has gone viral.

Journal Article

Blood, 133 (19), pp. 2001-2002, 2019, ISSN: 0006-4971.

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Saviola AJ, Zimmermann C, Mariani MP, Signorelli SA, Gerrard DL, Boyd JR, Wight DJ, Morissette G, Gravel A, Dubuc I, Flamand L, Kaufer BB, Frietze S

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A.

Journal Article

Front Microbiol, 10 , pp. 1408, 2019, ISSN: 1664-302X.

Abstract | Links:

Engdahl E, Gustafsson R, Huang J, Bistrom M, Lima Bomfim I, Stridh P, Khademi M, Brenner N, Butt J, Michel A, Jons D, Hortlund M, Alonso-Magdalena L, Hedstrom AK, Flamand L, Ihira M, Yoshikawa T, Andersen O, Hillert J, Alfredsson L, Waterboer T, Sundstrom P, Olsson T, Kockum I, Fogdell-Hahn A

Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis.

Journal Article

Front Immunol, 10 , pp. 2715, 2019, ISSN: 1664-3224.

Abstract | Links:

Wight DJ, Wallaschek N, Sanyal A, Weller SK, Flamand L, Kaufer BB

Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration.

Journal Article

Viruses, 10 (11), 2018, ISSN: 1999-4915.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • COVID-19 trilogy: ARDS, inflammation and coagulopathy, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement : Possibilité de financement pour une intervention de recherche rapide contre la COVID-19, from 2020-06-01 to 2021-05-31
  • Human herpesvirus 6 and chromosomal integration, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-03-01 to 2021-02-28
  • The impact of antimalarial drugs in arthritis patients exposed to SARS-CoV-2- the CoVIRAL project, Subvention, La société d'arthrite, from 2020-04-01 to 2023-03-31
  • Understanding the pathogenesis of COVID-19, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement : Possibilité de financement canadienne pour une intervention de recherche rapide contre la maladie à coronavirus 2019 (COVID-19), from 2020-03-01 to 2021-02-28

Recently finished projects

  • Caractérisation du rôle de la protéine précoce immédiate 1 dans l'intégration chromosomique des herpèsvirus humains, Subvention, MITACS Inc., Bourse de recherche Mitacs Globalink, from 2019-01-14 to 2019-06-06
  • Financement d'un projet de recherche dans l'axe MII, Subvention, Fondation du CHU de Québec, from 2019-11-11 to 2020-03-31
  • Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases, Subvention, Fondation des maladies du coeur et de l'AVC du Canada, Subventions de recherche, from 2017-04-01 to 2020-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2020-03-31
Data provided by the Université Laval research projects registery