Dr. Louis Flamand is a full professor and vice-chair of the department of microbiology-infectious disease-immunology at the Laval University School of Medicine and senior researcher in the division of infectious and immune diseases at the CHU de Quebec Research Center. Before joining Laval University, Dr. Flamand obtained his PhD at the University of Montreal and post-doctoral training that the National Institutes of Health and at the Institute of Human Virology (Maryland, USA). He received his MBA in pharmaceutical management from Laval University. Since 2008, he has been President of the biohazards risk committee at Laval University. He has also been a member of the HHV-6 Foundation scientific advisory board since 2006. Dr. Flamand has experience in pre-clinical development. Throughout his career, Dr. Flamand has received several competitive scholarship awards and continuous funding support from several funding agencies for his work in virology. Dr. Flamand is the author of more than 80 peer-reviewed publications and is lead Editor of the book “Human Herpesviruses HHV-6A, HHV-6B & HHV-7: Diagnosis and Clinical Management” 3rd edition.

Biological consequences of chromosomal integration by human herpesvirus 6 (HHV-6).

HHV-6 has the remarkable ability to integrate its genome in the cells that it infects. Remarkably, about 1% of the population carries a copy of the viral genome integrated in a chromosome of each cell. These individuals, referred to as inherited-chromosomally-integrated individuals (iciHHV-6), represent one of the main topics studied by Dr. Flamand and his team. HHV-6 genome integration occurs near the ends of chromosomes, in the telomere. Telomeres play a major role in cellular homeostasis by protecting the ends of chromosomes against the development of the DNA damage response, and play a key role in the long-term proliferative capacity of cells. It is therefore anticipated that the presence of the integrated virus in the telomere of ici HHV-6+ individuals may represent a risk factor for the development of various diseases. Dr. Flamand and his team recently reported that iciHHV-6+ subjects are 3X more at risk for developing angina pectoris, a cardiovascular disease (Gravel et al 2015 PNAS). Work in progress in the laboratory is aimed at better understanding the link between HHV-6 integration and the development of angina.

Understand the molecular and cellular mechanisms that lead to HHV-6 chromosomal integration.

Dr. Flamand’s laboratory is interested in identifying the mechanisms and viral/cellular factors underlying HHV-6 integration. Having successfully developed a cell culture model allowing them to study the integration of HHV-6, Dr. Flamand and his team are currently studying the viral and cellular proteins that play a role in HHV-6 integration process.

CHUL
2705, boulevard Laurier
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Québec, Québec
Canada G1V 4G2
86 entries « 1 of 9 »

Komaroff AL, Zerr DM, Flamand L

Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7.

Journal Article

J Med Virol, 92 (1), pp. 4-10, 2020, ISSN: 0146-6615.

Abstract | Links:

Mouammine A, Gravel A, Dubuc I, Feroz Zada Y, Provost S, Busseuil D, Tardif JC, Dube MP, Flamand L

rs73185306 C/T is not a predisposing risk factor for inherited chromosomally-integrated human herpesvirus 6A/B.

Journal Article

J Infect Dis, 2019, ISSN: 0022-1899.

Abstract | Links:

Peddu V, Dubuc I, Gravel A, Xie H, Huang ML, Tenenbaum D, Jerome KR, Tardif JC, Dube MP, Flamand L, Greninger AL

Inherited chromosomally integrated HHV-6 demonstrates tissue-specific RNA expression in vivo that correlates with increased antibody immune response.

Journal Article

J Virol, 2019, ISSN: 0022-538X.

Abstract | Links:

Boilard E, Flamand L

The role of the megakaryocyte in immunity has gone viral.

Journal Article

Blood, 133 (19), pp. 2001-2002, 2019, ISSN: 0006-4971.

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Saviola AJ, Zimmermann C, Mariani MP, Signorelli SA, Gerrard DL, Boyd JR, Wight DJ, Morissette G, Gravel A, Dubuc I, Flamand L, Kaufer BB, Frietze S

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A.

Journal Article

Front Microbiol, 10 , pp. 1408, 2019, ISSN: 1664-302X.

Abstract | Links:

Wight DJ, Wallaschek N, Sanyal A, Weller SK, Flamand L, Kaufer BB

Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration.

Journal Article

Viruses, 10 (11), 2018, ISSN: 1999-4915.

Abstract | Links:

Sanyal A, Wallaschek N, Glass M, Flamand L, Wight DJ, Kaufer BB

The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome.

Journal Article

Viruses, 10 (8), 2018, ISSN: 1999-4915.

Abstract | Links:

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Journal Article

Proc Natl Acad Sci U S A, 115 (7), pp. E1550-E1559, 2018, ISSN: 0027-8424.

Abstract | Links:

Flamand L

Chromosomal Integration by Human Herpesviruses 6A and 6B.

Journal Article

Adv Exp Med Biol, 1045 , pp. 209-226, 2018, ISSN: 0065-2598.

Abstract | Links:

Gravel A, Dubuc I, Wallaschek N, Gilbert-Girard S, Collin V, Hall-Sedlak R, Jerome KR, Mori Y, Carbonneau J, Boivin G, Kaufer BB, Flamand L

Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration.

Journal Article

J Virol, 91 (14), 2017, ISSN: 0022-538X.

Abstract | Links:

86 entries « 1 of 9 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Human herpesvirus 6 and chromosomal integration, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Inherited chromosomally-integrated human herpesvirus 6 and cardiovascular diseases, Subvention, Fondation des maladies du coeur et de l'AVC du Canada, Subventions de recherche, from 2017-04-01 to 2020-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2020-03-31

Recently finished projects

  • 11th International Conference on human herpesviruses 6A, 68 and 7., Subvention, Instituts de recherche en santé du Canada, Subvention de planification et dissémination, from 2018-12-01 to 2019-03-31
  • Caractérisation du rôle de la protéine précoce immédiate 1 dans l'intégration chromosomique des herpèsvirus humains, Subvention, MITACS Inc., Bourse de recherche Mitacs Globalink, from 2019-01-14 to 2019-06-06
Data provided by the Université Laval research projects registery