Dr. Louis Bessette graduated from medical school and completed his residency in Internal Medicine and Rheumatology at Laval University. He trained as a fellow in clinical research at the Multipurpose Arthritis Center, Brigham and Women’s Hospital in Boston and received a master’s degree in epidemiology from the Harvard School of Public Health.
He is a clinical researcher at the Centre de recherche du CHU de Québec-Laval University, assistant professor at Laval University’s School of Medicine. Since 2014, he has been Chief of the Rheumatology Department at the CHU de Québec-Laval University. His main research interests are rheumatoid arthritis and osteoporosis, as well as the quality of life aspects and pharmacoeconomic studies related to these diseases.
Dr. Bessette is the principal investigator of the CATCH study in Quebec City (Canadian Early Arthritis Cohort Study). CATCH is a Canadian multicentre research program that aims at improving the quality of care for people with early inflammatory arthritis. Over 2,000 people are participating in our investigator-initiated research program across Canada (100 subjects in Quebec City). This is the only Canada-wide early arthritis cohort that follows people with new onset inflammatory or rheumatoid arthritis over time to examine the course of their disease and their response to the treatments provided by their healthcare team.
He is co-investigator of the Group for Early Arthritis Research (GEAR). GEAR is a multidisciplinary team of the CHU de Québec-Laval University composed of clinicians and clinical researchers in the field of rheumatology. A model for an early arthritis clinic was put in place in 2014 to give better and earlier access to patients who suffer from rheumatic conditions. Other objectives are to collect clinical data and bio specimens on patients with early arthritis to better understand disease progression and its complications. Collecting these data and bio specimens will provide information on the population in the CHU de Québec-Laval University catchment area, and allow to elaborate strategies to improve patient care and prevent comorbid conditions in patients with early arthritis.
Dr. Bessette is co-director for the CaMOS Quebec City Centre, a large Canadian epidemiologic study in osteoporosis. He is also co-investigator of the Recognizing Osteoporosis and its Consequences in Quebec (ROCQ) Programme, a patient health-management programme aimed at evaluating the diagnostic and treatment care gaps for osteoporosis following a fragility fracture in women aged 50 years and over.
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Treating rheumatoid arthritis to target: a Canadian physician survey.Journal Article
J Rheumatol, 39 (5), pp. 949-53, 2012, ISSN: 0315-162X.
Algorithms can be used to identify fragility fracture cases in physician-claims databases.Journal Article
Osteoporos Int, 23 (2), pp. 483-501, 2012, ISSN: 0937-941X.
The impact of two educational interventions on osteoporosis diagnosis and treatment after fragility fracture: a population-based randomized controlled trial.Journal Article
Osteoporos Int, 22 (12), pp. 2963-72, 2011, ISSN: 0937-941X.
Safety and effectiveness of rituximab in patients with rheumatoid arthritis following an inadequate response to 1 prior tumor necrosis factor inhibitor: the RESET Trial.Journal Article
J Rheumatol, 38 (12), pp. 2548-56, 2011, ISSN: 0315-162X.
The burden of osteoporotic fractures beyond acute care: the Canadian Multicentre Osteoporosis Study (CaMos).Journal Article
Age Ageing, 40 (5), pp. 602-7, 2011, ISSN: 0002-0729.
Spine-hip T-score difference predicts major osteoporotic fracture risk independent of FRAX(®): a population-based report from CAMOS.Journal Article
J Clin Densitom, 14 (3), pp. 286-93, 2011, ISSN: 1094-6950.
Independent external validation of nomograms for predicting risk of low-trauma fracture and hip fracture.Journal Article
CMAJ, 183 (2), pp. E107-14, 2011, ISSN: 0820-3946.
Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial.Journal Article
Ann Rheum Dis, 70 (1), pp. 39-46, 2011, ISSN: 0003-4967.
Evaluation of abatacept in biologic-naive patients with active rheumatoid arthritis.Journal Article
Clin Rheumatol, 29 (6), pp. 583-91, 2010, ISSN: 0770-3198.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Platelets and neutrophils: the two culprits mediating pain in inflammatory arthritis, Subvention, La société d'arthrite, from 2020-01-01 to 2022-12-31
Recently finished projects
- Canadian Network for Advanced interdisciplinary Methods for Prospective Studies of Drug Safety and Effectiveness., Subvention, Instituts de recherche en santé du Canada, Subvention d'équipe : Centre de collaboration pour les études prospectives du RIEM, from 2014-09-01 to 2019-08-31
- Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31