Dr. Line Guénette is a researcher within the Population Health and Health Best Practices Axis of the CHU of Quebec-Laval University Research Centre, as well as an Associate Professor in the Faculty of Pharmacy at Laval University. She is also a clinical pharmacist within the CIUSSS de la Capitale-Nationale. Her research program aims to identify and better understand the issues of drug use, particularly in people with diabetes and the elderly. She is also working to find efficient ways to optimize the use of medicines and to transform professional practices.

She is the recipient of a clinical investigator-junior 1 fellowship from the Fonds de la recherche Québec-Santé (FRQ-S) and of the FRQ-S/Société québécoise d’hypertension artérielle (SQHA) Jacques-de-Champlain Scholarship.

Towards a better understanding of the problems of drug use

Although there are now several effective and well-tolerated drugs to control several chronic diseases and reduce associated complications, problems of poor control are still too common. One of the most important barriers to optimal treatment of chronic diseases is the non-optimal use of drugs by patients and health professionals. The first step to optimize the use of medicines is to better understand the determinants of misuse. Dr. Guénette and her team are achieving this by using large databases of administrative data or surveys of patients and health professionals.

Optimizing the use of medicines

According to recent literature reviews, studies that evaluate the effectiveness of interventions to optimize drug use often have important methodological shortcomings. Moreover, very few of them describe in detail the applied interventions, the targeted determinants and the design of the interventions. It is therefore essential to improve research on the best ways to intervene and on the interventions most likely to be implemented in the Quebec context. It is also crucial to work towards reducing inappropriate practices and implementing new knowledge and activities with proven benefits. To achieve this, Dr. Guénette works closely with clinicians and decision-makers in clinical settings. A project to implement and evaluate the impact of pharmacists’ new activities under Bill 41 is currently underway.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J1-08
Québec, Québec
Canada G1S 4L8
59 entries « 3 of 6 »

Lawani MA, Zongo F, Breton MC, Moisan J, Gregoire JP, Dorval E, Boulet LP, Jobin FM, Guenette L

Factors associated with adherence to asthma treatment with inhaled corticosteroids: A cross-sectional exploratory study.

Journal Article

J Asthma, 55 (3), pp. 318-329, 2018, ISSN: 0277-0903.

Abstract | Links:

Reynolds E, Guenette L, Lexchin J, Cassels A, Wilkes MS, Durrieu G, Beaulieu MD, Mintzes B

Reconciling a "pleasant exchange" with evidence of information bias: A three-country study on pharmaceutical sales visits in primary care.

Journal Article

Health Policy, 122 (3), pp. 250-255, 2018, ISSN: 0168-8510.

Abstract | Links:

Lunghi C, Zongo A, Guénette L

Utilisation des bases de données médico-administratives du Québec pour des études en santé mentale : opportunités, défis méthodologiques et limites – cas de la dépression chez les personnes diabétiques

Journal Article

Sante Ment Que, 43 (2), pp. 107-126, 2018, ISSN: 0383-6320.

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Lunghi C, Zongo A, Moisan J, Gregoire JP, Guenette L

The impact of incident depression on medication adherence in patients with type 2 diabetes.

Journal Article

Diabetes Metab, 43 (6), pp. 521-528, 2017, ISSN: 1262-3636.

Abstract | Links:

Leclerc J, Blais C, Rochette L, Hamel D, Guenette L, Poirier P

Impact of the Commercialization of Three Generic Angiotensin II Receptor Blockers on Adverse Events in Quebec, Canada: A Population-Based Time Series Analysis.

Journal Article

Circ Cardiovasc Qual Outcomes, 10 (10), 2017, ISSN: 1941-7713.

Abstract | Links:

Hudon C, Chouinard MC, Aubrey-Bassler K, Muhajarine N, Burge F, Pluye P, Bush PL, Ramsden VR, Legare F, Guenette L, Morin P, Lambert M, Groulx A, Couture M, Campbell C, Baker M, Edwards L, Sabourin V, Spence C, Gauthier G, Warren M, Godbout J, Davis B, Rabbitskin N

Case management in primary care among frequent users of healthcare services with chronic conditions: protocol of a realist synthesis.

Journal Article

BMJ Open, 7 (9), pp. e017701, 2017.

Abstract | Links:

Trudel X, Milot A, Gilbert-Ouimet M, Duchaine C, Guenette L, Dalens V, Brisson C

Effort-Reward Imbalance at Work and the Prevalence of Unsuccessfully Treated Hypertension Among White-Collar Workers.

Journal Article

Am J Epidemiol, 186 (4), pp. 456-462, 2017, ISSN: 0002-9262.

Abstract | Links:

Kroger E, Tatar O, Vedel I, Giguere AMC, Voyer P, Guillaumie L, Gregoire JP, Guenette L

Improving medication adherence among community-dwelling seniors with cognitive impairment: a systematic review of interventions.

Journal Article

Int J Clin Pharm, 39 (4), pp. 641-656, 2017.

Abstract | Links:

Lunghi C, Zongo A, Moisan J, Gregoire JP, Guenette L

Factors associated with antidiabetic medication non-adherence in patients with incident comorbid depression.

Journal Article

J Diabetes Complications, 31 (7), pp. 1200-1206, 2017, ISSN: 1056-8727.

Abstract | Links:

Sirois C, Laroche ML, Guenette L, Kroger E, Cooper D, Emond V

Polypharmacy in multimorbid older adults: protocol for a systematic review.

Journal Article

Syst Rev, 6 (1), pp. 104, 2017, ISSN: 2046-4053.

Abstract | Links:

59 entries « 3 of 6 »
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Active projects

  • Case management in primary care for frequent users of healthcare services with chronic diseases and complex care needs: implementation and realist evaluations, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement : Réseau de la SRAP sur les ISSIPL – subventions programmatiques, from 2018-01-01 to 2021-12-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Coûts des maladies cardiovasculaires et des problèmes de santé mentale attribuables aux contraintes psychosociales au travail : Une étude longitudinale de 22 ans auprès de 9 000 cols blancs., Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-03-31
  • Développement et validation d’une technique pour l’identification et la recommandation d’outils numériques en santé aux patients pour la gestion des maladies chroniques par les pharmaciens communautaires, Subvention, Medteq, from 2019-11-01 to 2022-06-30
  • Optimisation de l’usage - Soins pharmaceutiques en première ligne: une communauté de pratique à l'intention des pharmaciens, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2017-08-22 to 2021-03-31
  • Pilot study of a community pharmacy-based program to enhance adherence to adjuvant endocrine therapy among breast, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2022-02-28
  • Projet GPS: Évaluation de l'impact de la réorganisation du travail en Groupe de médecine de famille (GMF) sur la Pharmacothérapie et le Soutien à l'autonomie des personnes âgées ayant un trouble neuro-cognitif majeur, Subvention, Fonds de recherche du Québec - Santé, Plateforme de financements de la recherche intersectorielle sur le vieillissement - Living Lab, from 2019-04-01 to 2022-06-30
  • The Multimorbidity Treatment Burden Questionnaire (MTBQ): translation and validation in French, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2019-04-01 to 2020-09-30
  • VITAM – Centre de recherche en santé durable, Subvention, CIUSSS - CN - VITAM, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31

Recently finished projects

  • Anxio-depressive symptom and treatment adherence trajectories associated with clinical outcomes and quality of life in a community sample of older adults with chronic disorders, Subvention, Instituts de recherche en santé du Canada, Programme de subvention Catalyseur, from 2017-09-01 to 2019-08-31
  • Fonds de soutien sur l'adhésion aux traitements, Subvention, Fondation de l'Université Laval, from 2017-01-01 to 2020-04-30
  • Projet d'évaluation de la personnalisation des soins pharmaceutiques (PEPS) en centre d'hébergement de soins de longue durée (CHSLD), Subvention, Ministère de la Santé et des Services sociaux, from 2018-05-11 to 2019-06-30
  • Question pour un pharmacien : un service de téléconsultation offert par des pharmaciens pour prodiguer des soins de santé de qualité au Québec, Subvention, Fonds de recherche du Québec - Santé, Réseau de connaissances du FRQ-S, from 2018-02-05 to 2019-08-31
  • Réseau-1 Québec (Réseau de recherche en soins et services de santé de première ligne), Subvention, Fonds de recherche du Québec - Santé, Réseau de connaissances du FRQ-S, from 2013-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery