Dr. Line Guénette is a researcher within the Population Health and Health Best Practices Axis of the CHU of Quebec-Laval University Research Centre, as well as an Associate Professor in the Faculty of Pharmacy at Laval University. She is also a clinical pharmacist within the CIUSSS de la Capitale-Nationale. Her research program aims to identify and better understand the issues of drug use, particularly in people with diabetes and the elderly. She is also working to find efficient ways to optimize the use of medicines and to transform professional practices.

She is the recipient of a clinical investigator-junior 1 fellowship from the Fonds de la recherche Québec-Santé (FRQ-S) and of the FRQ-S/Société québécoise d’hypertension artérielle (SQHA) Jacques-de-Champlain Scholarship.

Towards a better understanding of the problems of drug use

Although there are now several effective and well-tolerated drugs to control several chronic diseases and reduce associated complications, problems of poor control are still too common. One of the most important barriers to optimal treatment of chronic diseases is the non-optimal use of drugs by patients and health professionals. The first step to optimize the use of medicines is to better understand the determinants of misuse. Dr. Guénette and her team are achieving this by using large databases of administrative data or surveys of patients and health professionals.

Optimizing the use of medicines

According to recent literature reviews, studies that evaluate the effectiveness of interventions to optimize drug use often have important methodological shortcomings. Moreover, very few of them describe in detail the applied interventions, the targeted determinants and the design of the interventions. It is therefore essential to improve research on the best ways to intervene and on the interventions most likely to be implemented in the Quebec context. It is also crucial to work towards reducing inappropriate practices and implementing new knowledge and activities with proven benefits. To achieve this, Dr. Guénette works closely with clinicians and decision-makers in clinical settings. A project to implement and evaluate the impact of pharmacists’ new activities under Bill 41 is currently underway.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J1-08
Québec, Québec
Canada G1S 4L8
51 entries « 1 of 6 »

Maheu A, Vanier MC, Rouleau L, Dugre N, Guenette L

The Creation of a Practice-Based Network of Pharmacists Working in Family Medicine Groups (FMG).

Journal Article

Pharmacy (Basel), 7 (3), 2019, ISSN: 2226-4787.

Abstract | Links:

Leclerc J, Blais C, Rochette L, Hamel D, Guenette L, Poirier P

Did Generic Clopidogrel Commercialization Affect Trends of ER Consultations and Hospitalizations in the Population Treated with Clopidogrel?

Journal Article

Drugs Aging, 36 (8), pp. 759-768, 2019, ISSN: 1170-229X.

Abstract | Links:

Zongo A, Gregoire JP, Moisan J, Guenette L

Measuring adherence to oral antidiabetic multi-drug treatment: Comparative validity of prescription claims-based adherence measures against hospitalization.

Journal Article

Res Social Adm Pharm, 15 (6), pp. 738-743, 2019, ISSN: 1551-7411.

Abstract | Links:

Leclerc J, Blais C, Rochette L, Hamel D, Guenette L, Poirier P

Trends in Hospital Visits for Generic and Brand-Name Warfarin Users in Québec, Canada: A Population-Based Time Series Analysis.

Journal Article

Am J Cardiovasc Drugs, 19 (3), pp. 287-297, 2019, ISSN: 1175-3277.

Abstract | Links:

Mercer K, Guirguis L, Burns C, Chin J, Dogba MJ, Dolovich L, Guenette L, Jenkins L, Legare F, McKinnon A, McMurray J, Waked K, Grindrod KA

Exploring the role of teams and technology in patients' medication decision making.

Journal Article

J Am Pharm Assoc (2003), 59 (2S), pp. S35-S43.e1, 2019, ISSN: 1544-3191.

Abstract | Links:

Vignon Zomahoun HT, de Bruin M, Guillaumie L, Moisan J, Gregoire JP, Guenette L, Perez N, Vezina-Im LA

Response to letter to the editor related to the retraction of a trial included in a meta-analysis of interventions to enhance oral medication adherence titled "Effectiveness and content analysis of interventions to enhance oral antidiabetic drug adherence in adults with type 2 diabetes: Systematic review and meta-analysis".

Journal Article

Value Health, 22 (2), pp. 264-266, 2019, ISSN: 1098-3015.

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Chartrand M, Lalonde L, Cantin A, Lahaie A, Odobasic B, Tremblay MP, Wazzan D, Gagnon MM, Martin E, Dorais M, Berbiche D, Guenette L

Anticoagulation management services in community pharmacy: Feasibility of implementing a quality improvement programme through a practice-based research network.

Journal Article

J Clin Pharm Ther, 43 (6), pp. 877-887, 2018, ISSN: 0269-4727.

Abstract | Links:

Hudon C, Chouinard MC, Aubrey-Bassler K, Burge F, Doucet S, Ramsden VR, Brodeur M, Bush PL, Couturier Y, Dubois MF, Guenette L, Legare F, Morin P, Poder TG, Poitras ME, Roberge P, Valaitis R, Bighead S, Campbell C, Couture M, Davis B, Deschenes E, Edwards L, Gander S, Gauthier G, Gauthier P, Gibson RJ, Godbout J, Landry G, Longjohn C, Rabbitskin N, Roy DA, Roy J, Sabourin V, Sampalli T, Saulnier A, Spence C, Splane J, Warren M, Young J, Pluye P

Case management in primary care for frequent users of healthcare services with chronic diseases and complex care needs: an implementation and realist evaluation protocol.

Journal Article

BMJ Open, 8 (11), pp. e026433, 2018.

Abstract | Links:

Mercer K, Burns C, Guirguis L, Chin J, Dogba MJ, Dolovich L, Guenette L, Jenkins L, Legare F, McKinnon A, McMurray J, Waked K, Grindrod KA

Physician and Pharmacist Medication Decision-Making in the Time of Electronic Health Records: Mixed-Methods Study.

Journal Article

JMIR Hum Factors, 5 (3), pp. e24, 2018, ISSN: 2292-9495.

Abstract | Links:

Chartrand M, Guenette L, Brouillette D, Cote S, Huot R, Landry J, Martineau J, Perreault S, White-Guay B, Williamson D, Martin E, Gagnon MM, Lalonde L

Development of Quality Indicators to Assess Oral Anticoagulant Management in Community Pharmacies for Patients with Atrial Fibrillation.

Journal Article

J Manag Care Spec Pharm, 24 (4), pp. 357-365, 2018.

Abstract | Links:

51 entries « 1 of 6 »
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Active projects

  • Anxio-depressive symptom and treatment adherence trajectories associated with clinical outcomes and quality of life in a community sample of older adults with chronic disorders, Subvention, Instituts de recherche en santé du Canada, Programme de subvention Catalyseur, from 2017-09-01 to 2019-08-31
  • Case management in primary care for frequent users of healthcare services with chronic diseases and complex care needs: implementation and realist evaluations, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement : Réseau de la SRAP sur les ISSIPL – subventions programmatiques, from 2018-01-01 to 2021-12-31
  • Centre de recherche sur les soins et les services de première ligne de l'Université Laval (CERSSPL-UL), Subvention, CIUSSS - CN - Centre de recherche sur les soins et les services de première ligne de l'ULaval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Coûts des maladies cardiovasculaires et des problèmes de santé mentale attribuables aux contraintes psychosociales au travail : Une étude longitudinale de 22 ans auprès de 9 000 cols blancs., Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2020-06-30
  • Fonds de soutien sur l'adhésion aux traitements, Subvention, Fondation de l'Université Laval, from 2017-01-01 to 2020-04-30
  • Projet GPS: Évaluation de l'impact de la réorganisation du travail en Groupe de médecine de famille (GMF) sur la Pharmacothérapie et le Soutien à l'autonomie des personnes âgées ayant un trouble neuro-cognitif majeu, Subvention, Fonds de recherche du Québec - Santé, Plateforme de financements de la recherche intersectorielle sur le vieillissement, from 2019-04-01 to 2022-03-31
  • Subvention de fonctionnement 2017-2018, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2017-08-22 to 2020-08-21

Recently finished projects

  • Enhancing adherence to adjuvant endocrine therapy among breast cancer survivors: Pilot study of the S.O.I.E. program, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-04-01 to 2018-04-30
  • L'adhésion au traitement chez les personnes souffrant de maladies chroniques : étude des facteurs causant la non-adhésion et des interventions pour améliorer l'adhésion chez les diabétiques de type 2, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2014-07-01 to 2018-06-30
  • Projet PEPS – Projet d’évaluation de la personnalisation des soins pharmaceutiques en soins de longue durée (SLD), Subvention, CIUSSS - CN - Centre de recherche sur les soins et les services de première ligne de l'ULaval, from 2017-07-01 to 2018-06-30
  • Réseau-1 Québec (Réseau de recherche en soins et services de santé de première ligne), Subvention, Fonds de recherche du Québec - Santé, Réseau de connaissances du FRQ-S, from 2013-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery