Dr. St-Amand completed his doctoral studies at Laval University, and his postdoctoral studies at the University of British Columbia. In 1998, he optimized the SAGE method in his laboratory located in Japan, at the pharmaceutical company Otsuka. He is currently a full professor in the Department of Molecular Medicine at Laval University, and director of the Functional Genomics Laboratory and SAGE platform at the CHU Research Centre of Quebec. He is an expert in genetic engineering and functional genomics.

Dr. St-Amand’s research program aims to characterize the transcriptomes of several tissues and their regulation through physical exercise, a lipid-rich diet, and steroid hormones, in order to identify, clone and characterize functionally the genes of interest that can be used as therapeutic targets for coronary heart disease, obesity, and cancer. Dr. St-Amand’s laboratory is developing genetic engineering methods and bioinformatics programs, particularly for the analysis of functional genomics results. Dr. St-Amand developed the first SAGE platform in Canada. This powerful strategy makes it possible to compare all transcripts, including new genes, to identify the molecular mechanisms responsible for diseases.

Dr. St-Amand and his team are also studying in vitro cells and knockout mice to characterize the functions of candidate genes. These research projects will identify therapeutic targets to, in turn, develop therapeutic treatments for obesity and cardiovascular disease.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4775
Québec, Québec
Canada G1V 4G2

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56 entries « 5 of 6 »

Nishida Y, Yoshioka M, St-Amand J

Regulation of hypothalamic gene expression by glucocorticoid: implications for energy homeostasis.

Journal Article

Physiol Genomics, 25 (1), pp. 96-104, 2006, ISSN: 1094-8341.

Abstract | Links:

Nishida Y, Yoshioka M, St-Amand J

Sexually dimorphic gene expression in the hypothalamus, pituitary gland, and cortex.

Journal Article

Genomics, 85 (6), pp. 679-87, 2005, ISSN: 0888-7543.

Abstract | Links:

Ye P, Yoshioka M, Gan L, St-Amand J

Regulation of global gene expression by ovariectomy and estrogen in female adipose tissue.

Journal Article

Obes Res, 13 (6), pp. 1024-30, 2005, ISSN: 1071-7323.

Abstract | Links:

Yoshioka M, Ayabe M, Yahiro T, Higuchi H, Higaki Y, St-Amand J, Miyazaki H, Yoshitake Y, Shindo M, Tanaka H

Long-period accelerometer monitoring shows the role of physical activity in overweight and obesity.

Journal Article

Int J Obes (Lond), 29 (5), pp. 502-8, 2005, ISSN: 0307-0565.

Abstract | Links:

Nishida Y, Yoshioka M, St-Amand J

The top 10 most abundant transcripts are sufficient to characterize the organs functional specificity: evidences from the cortex, hypothalamus and pituitary gland.

Journal Article

Gene, 344 , pp. 133-41, 2005, ISSN: 0378-1119.

Abstract | Links:

Dinel S, Bolduc C, Belleau P, Boivin A, Yoshioka M, Calvo E, Piedboeuf B, Snyder EE, Labrie F, St-Amand J

Reproducibility, bioinformatic analysis and power of the SAGE method to evaluate changes in transcriptome.

Journal Article

Nucleic Acids Res, 33 (3), pp. e26, 2005, ISSN: 0305-1048.

Abstract | Links:

St-Amand J, Tanakam H, Shono N, Snyder EE, Shindo M, Yoshioka M

SAGE Identifies Transcripts Involved in Enhanced Performance of Endurance Athlete's Muscle

Book Chapter

SM, Wang (Ed.): SAGE: Current Technologies and Applications, pp. 265-280, Norfolk, England, Horizon Bioscience, 2005, ISBN: 1904933076.

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Bolduc C, Larose M, Yoshioka M, Ye P, Belleau P, Labrie C, Morissette J, Raymond V, Labrie F, St-Amand J

Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression.

Journal Article

J Mol Endocrinol, 33 (2), pp. 429-44, 2004, ISSN: 0952-5041.

Abstract | Links:

Yoshioka M, Imanaga M, Ueyama H, Yamane M, Kubo Y, Boivin A, St-Amand J, Tanaka H, Kiyonaga A

Maximum tolerable dose of red pepper decreases fat intake independently of spicy sensation in the mouth.

Journal Article

Br J Nutr, 91 (6), pp. 991-5, 2004, ISSN: 0007-1145.

Abstract | Links:

Larose M, St-Amand J, Yoshioka M, Belleau P, Morissette J, Labrie C, Raymond V, Labrie F

Transcriptome of mouse uterus by serial analysis of gene expression (SAGE): comparison with skeletal muscle.

Journal Article

Mol Reprod Dev, 68 (2), pp. 142-8, 2004, ISSN: 1040-452X.

Abstract | Links:

56 entries « 5 of 6 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Roles of exercise-induced gene, SPARC, against sarcopenia: Link between extracellular matrix and mitochondria., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2021-03-31
Data provided by the Université Laval research projects registery